Yan Xu

Relationship between serum LDH levels and diabetic peripheral neuropathy in type 2 diabetic patients

Meng Sun, Zhaodi Wang, Yan Xu, Hongqiao Yang et autres

Background: Diabetic peripheral neuropathy (DPN) is commonly observed as a long-term complication in patients with type 2 diabetes mellitus (T2DM). Recent evidence suggests that metabolic disturbances and chronic inflammation may contribute to its development. Lactate dehydrogenase (LDH), a key enzyme in glycolysis, …

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Tumor-derived progranulin reprograms immunosuppressive macrophages via cholesterol efflux in oral squamous cell carcinoma

Chengzhe Yang, Yan Xu, Simin Zhao, Hao Li et autres

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Potential biomarkers of primary resistance to first- and second-generation EGFR-TKIs in non-small-cell lung cancer: a real-world study

Jingyi Wang, Bolin Chen, Xingxiang Pu, Yan Xu et autres

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) significantly improve the prognosis of EGFR-sensitive mutant non-small-cell lung cancer (NSCLC). However, the mechanisms underlying primary resistance to EGFR-TKIs remain unclear. Objective: This study aimed to explore the biomarkers associated with primary resistance …

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Assessment of the humoral immune status of varicella-zoster virus in patients with diffuse connective tissue diseases

Xiang Yuan Sun, Yinshan Zang, Yan Xu, Wen Wang

Background Diffuse connective tissue diseases (DCTDs) require long-term immunosuppressive treatment, increasing the risk of varicella-zoster virus (VZV) infection. This study aims to evaluate the humoral immune status against VZV in DCTD patients and explore factors that may influence their immune levels. Methods …

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Exposure level and risk assessment of atrazine in Chinese adults based on the systematic review data and the Monte Carlo simulation method

Yan Xu, Xiaoqi Fang, Haotang Zhao, Hui Ye et autres

As an environmental endocrine disruptor, atrazine (ATR) can produce serious health damage to humans. This study aimed to assess the exposure and health risks associated with ATR among Chinese adults by analyzing data on ATR concentrations in various environmental media across China. …

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Relationship between changes in late-life blood pressure and the risk of frailty and mortality among older population in China: a cohort study based on CLHLS

Yana Chen, Yanfang Wang, Yan Xu, Shunyao Shi et autres

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Trends in colorectal cancer screening in the United States, 2012 to 2020

Yue He, Tong Xu, Jiaxin Fang, Tong Li et autres

Objectives Despite recommendations to increase the uptake of colorectal cancer (CRC) screening, trends in CRC screening vary with sociodemographic status. We aimed to evaluate trends in CRC screening in the US population and subpopulations. Methods A total of 1,082,924 participants aged 50 …

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The redox cycling of STAT2 maintains innate immune homeostasis

Binbin Xue, Huiyi Li, Shun Liu, Qing Feng et autres

Interferons (IFNs) are essential in antiviral defense, antitumor effects, and immunoregulatory activities. Although methionine oxidation is associated with various physiological and pathophysiological processes in plants, animals, and humans, its role in immunity remains unclear. We find that the redox cycling of signal …

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The Relationship Between Zinc Deficiency and Hepatocellular Carcinoma Associated with Hepatitis B Liver Cirrhosis: A 10-year Follow-up Study

Shuai Wang, Xuemei Fan, Yang Gao, Lijuan Zuo et autres

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MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes

Yuezhu Zhang, Hui Ju, Yan Xu, Yingying Ma et autres

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P40.14 Efficacy and Safety of Endostar Combined With Camrelizumab and Chemotherapy in Treatment of Advanced NSCLC: A Multi-Center Retrospective Study

Lin Wu, Xingxiang Pu, Bolin Chen, Qiuhu Wang et autres

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Statin on post-stroke epilepsy: A systematic review and meta-analysis

Jiabin Fang, Minghui Tuo, Keni Ouyang, Yan Xu

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