Shun Liu

Genetic Variability of Human Papillomavirus Types 52, 58, and 16 Based on L1 Genes in Central China

Yang Yang, Ting Li, Zicong Lin, Sutong Wang et autres

Persistent exposure to high-risk human papillomavirus (HR-HPV) is a major contributing factor to cervical cancer. HPV-52, -58, and -16 are the top three prevalent HR-HPV types in Jingzhou. In this study, samples monoinfected with HPV-52 (n = 96), -58 (n = 98), …

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The prevalence trends of Trichomonas vaginalis infection among women in Jingzhou, central of China, 2019–2023

Yang Yan, Yue Qu, Bin Yan, Changzheng Wang et autres

BACKGROUND: Trichomonas vaginalis (T. vaginalis) is one of the most prevalent sexually transmitted infections globally, with significant regional variations in its prevalence. This study aimed to examine the epidemiological characteristics of T. vaginalis infection in Jingzhou, Hubei Province, China. METHODS: To obtain …

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BEV mit extrem niedrigem Luftwiderstandsbeiwert

Yang Liu, J. Fu, Linbo Zhang, Shun Liu

Association of fucosyltransferase 2 gene polymorphism with the susceptibility to norovirus infection in Han Chinese population

Shun Liu, Hanyu Chen, Zihan Wen, Yaoling Ouyang et autres

Fucosyltransferase 2 (FUT2) gene, which regulates the formation of Histoblood group antigens, could determine the human susceptibility to norovirus. This study aimed to investigate the correlation between FUT2 gene polymorphism and susceptibility to norovirus gastroenteritis in Han Chinese population. A total of …

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Prevalence of Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum among outpatients in central China: A retrospective study

Shun Liu, Yaoling Ouyang, Quan Tang, Bing Mei et autres

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Prevalence and genotype distribution of human papillomavirus infection among women in Jingzhou, China: a population-based study of 51,720 women

Shun Liu, Bing Mei, Yaoling Ouyang, Chengbin Li

BACKGROUND: Cervical cancer is the fourth most common cancer among women worldwide with a serious threat to women's health. Persistent infection with high-risk human papillomavirus (HR-HPV) has been identified as the main cause of cervical cancer. This study aimed to evaluate the …

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3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING

Qian Liu, Shengwen Chen, Renyun Tian, Binbin Xue et autres

ABSTRACT The mechanism by which lipid metabolism regulates innate immunity is unknown. Here, we report that the key enzyme in cholesterol synthesis, 3β-hydroxysteroid-Δ24 reductase (DHCR24), is inhibited by viral infection. DHCR24 deficiency significantly promotes interferon production and interferon-stimulated gene expression. Inhibition of …

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Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress

Huiyi Li, Shun Liu, Qing Feng, Rilin Deng et autres

The host always employs various ways to defend against viral infection and spread. However, viruses have evolved their own effective strategies, such as inhibition of RNA translation of the antiviral effectors, to destroy the host's defense barriers. Protein synthesis, commonly controlled by …

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The redox cycling of STAT2 maintains innate immune homeostasis

Binbin Xue, Huiyi Li, Shun Liu, Qing Feng et autres

Interferons (IFNs) are essential in antiviral defense, antitumor effects, and immunoregulatory activities. Although methionine oxidation is associated with various physiological and pathophysiological processes in plants, animals, and humans, its role in immunity remains unclear. We find that the redox cycling of signal …

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Regulation of protein translation by TRIM21

Huiyi Li, Shun Liu, Qing Feng, Rilin Deng et autres

Abstract Regulation of translation initiation is essential for maintenance of protein homeostasis and typically involves the phosphorylation of translation initiation factor eIF2α in eukaryotes. In response to stressors, cells employ eIF2α-dependent signaling to control translation initiation, which regulates multiple biological and physiological …

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Heat Shock-Binding Protein 21 Regulates the Innate Immune Response to Viral Infection

Yan Xu, Qiong Yang, Binbin Xue, Xintao Wang et autres

The innate immune system is the first-line host defense against microbial pathogen invasion. The physiological functions of molecular chaperones, involving cell differentiation, migration, proliferation and inflammation, have been intensively studied. HBP21 as a molecular chaperone is critical for tumor development. Tumor is …

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The Role of REC8 in the Innate Immune Response to Viral Infection

Shengwen Chen, Qian Liu, Lini Zhang, Jiahuan Ma et autres

The innate immune response is crucial for the host to resist the invasion of viruses and other pathogens. STING and MAVS play a critical role in the innate immune response to DNA and RNA viral infection, respectively. In this study, REC8 promoted …

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