Abdulkhaleg Ibrahim

[Corrigendum] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter et autres

for granting them the opportunity to publish this corrigendum, and all the authors agree with its publication. [International Journal of Oncology 59: 89, 2021; DOI: 10.3892/ijo.2021.5269].

fr (code pays fourni par la source)

[Expression of Concern] TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter et autres

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blots shown in Fig. 5A on p. 9 for the experiments without MG132 treatment ('‑ MMGM132') were strikingly similar to …

fr (code pays fourni par la source)

Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1

Khalid Ouararhni, Flore Mietton, Jamal S. M. Sabir, Abdulkhaleg Ibrahim et autres

The histone variant macroH2A (mH2A), the most deviant variant, is about threefold larger than the conventional histone H2A and consists of a histone H2A-like domain fused to a large Non-Histone Region responsible for recruiting PARP-1 to chromatin. The available data suggest that …

fr, sa, us, bg (code pays fourni par la source)

UHRF1 poly-auto-ubiquitination induced by the anti-cancer drug, thymoquinone, is involved in the DNA repair machinery recruitment.

Naif A. R. Almalki, Jamal S. M. Sabir, Abdulkhaleg Ibrahim, Mahmoud Alhosin et autres

fr, sa (code pays fourni par la source)

Identification and Characterization of HIRIP3 as a Histone H2A Chaperone

Maria Ignatyeva, Abdul Kareem Mohideen Patel, Abdulkhaleg Ibrahim, Raed S. Albiheyri et autres

HIRIP3 is a mammalian protein homologous to the yeast H2A.Z deposition chaperone Chz1. However, the structural basis underlying Chz's binding preference for H2A.Z over H2A, as well as the mechanism through which Chz1 modulates histone deposition or replacement, remains enigmatic. In this …

fr, sa (code pays fourni par la source)

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density

Christophe Papin, Abdulkhaleg Ibrahim, Jamal S. M. Sabir, Stéphanie Le Gras et autres

BACKGROUND: Inherited defects in the base-excision repair gene MBD4 predispose individuals to adenomatous polyposis and colorectal cancer, which is characterized by an accumulation of C > T transitions resulting from spontaneous deamination of 5'-methylcytosine. METHODS: Here, we have investigated the potential role …

fr, us, sa (code pays fourni par la source)

TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter et autres

Tat interactive protein, 60 kDa (TIP60) is an important partner of ubiquitin‑like, containing PHD and RING finger domains 1 (UHRF1), ensuring various cellular processes through its acetyltransferase activity. TIP60 is believed to play a tumor suppressive role, partly explained by its downregulated …

fr (code pays fourni par la source)

MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion

Abdulkhaleg Ibrahim, Christophe Papin, Kareem Mohideen-Abdul, Stéphanie Le Gras et autres

MeCP2 binds hydroxymethylated CA repeats Despites of decades of research on the Rett syndrome protein MeCP2, its function remains unclear. Ibrahim et al. show that MeCP2 is a hydroxymethylated cytosine-adenosine (CA) repeat-binding protein that modulates chromatin architecture at a distance from the …

fr, Libye, bg, sa (code pays fourni par la source)

CpG Islands Shape the Epigenome Landscape

Christophe Papin, Stéphanie Le Gras, Abdulkhaleg Ibrahim, Hatem H. Salem et autres

Epigenetic modifications and nucleosome positioning play an important role in modulating gene expression. However, how the patterns of epigenetic modifications and nucleosome positioning are established around promoters is not well understood. Here, we have addressed these questions in a series of genome-wide …

fr, gb, bg, sa (code pays fourni par la source)

TIP60 governs the auto-ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex

Tanveer Ahmad, Waseem Ashraf, Abdulkhaleg Ibrahim, Liliyana Zaayter et autres

Abstract Background: The epigenetic regulator UHRF1 (Ubiquitin-like, containing PHD and RING finger domains 1) plays an essential role in faithful transmission of DNA methylation during replication. It has tumorogenesis potential and is overexpressed in cancers. TIP60 (Tat interactive protein, 60 kDa) is …

fr (code pays fourni par la source)

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells

Abdulkhaleg Ibrahim, Mahmoud Alhosin, Christophe Papin, Khalid Ouararhni et autres

// Abdulkhaleg Ibrahim 1, 2, * , Mahmoud Alhosin 3, 4, * , Christophe Papin 1 , Khalid Ouararhni 1 , Ziad Omran 5 , Mazin A. Zamzami 3, 4 , Abdulrahman Labeed Al-Malki 3 , Hani Choudhry 3, 4 , Yves …

fr, sa (code pays fourni par la source)

Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N 4 -Erucoyl Spermidine

Syed Shoeb Razvi, Hani Choudhry, Mohammed Nihal Hasan, Mohammed Hassan et autres

Natural polyamines such as putrescine, spermidine, and spermine are crucial in the cell proliferation and maintenance in all the eukaryotes. However, the requirement of polyamines in tumor cells is stepped up to maintain tumorigenicity. Many synthetic polyamine analogues have been designed recently …

sa, ye, Égypte, fr, jp (code pays fourni par la source)