Ethan D. Smith

Acetylation Mimetic and Null Mutations Within the Filament Core of P301L Tau Have Varied Effects on Susceptibility to Seeding and Aggregation

Ethan D. Smith, Jose Torrellas, Robert W. McKenna, Quan Vo et autres

The two most prominent post-translational modifications of pathologic tau are Ser/Thr/Tyr phosphorylation and Lys acetylation. Whether acetylation impacts the susceptibility of tau to templated seeding in diseases like Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP) is largely uncharacterized. Towards this, we …

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Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases

Ethan D. Smith, Giavanna Paterno, Brach M. Bell, Kimberly-Marie M. Gorion et autres

Tauopathies, including Alzheimer's disease and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), are characterized by the aberrant aggregation of tau protein into neurofibrillary tangles. Despite extensive studies on tau aggregation, the mechanisms of tau misfolding and propagation remain incompletely understood. …

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BPS2025 - In vivo drug screening of zebrafish brain activity identifies potential targets for epilepsy and pain

Richard Kanyo, Ethan D. Smith, W. Ted Allison, Harley T. Kurata

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BPS2025 - In vivo drug screening of zebrafish brain activity identifies potential targets for epilepsy and pain

Richard Kanyo, Ethan D. Smith, W. Ted Allison, Harley T. Kurata

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Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation

Ethan D. Smith, Jose Torrellas, Robert W. McKenna, Stefan Prokop et autres

The two most prominent post-translational modifications of pathologic tau are Ser/Thr/Tyr phosphorylation and Lys acetylation. Whether acetylation impacts the susceptibility of tau to templated seeding in diseases like Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP) is largely uncharacterized. Towards this, we …

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Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon response

Kristen M. John, Ian Huntress, Ethan D. Smith, Hsuan Chou et autres

ABSTRACT Long noncoding RNAs (lncRNAs) are a newer class of noncoding transcripts identified as key regulators of biological processes. Here we aimed to identify novel lncRNA targets that play critical roles in major human respiratory viral infections by systematically mining large-scale transcriptomic …

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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

Ethan D. Smith, Quan Vo, Benoit I. Giasson, David Borchelt et autres

Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated from Alzheimer's disease (AD-tau) or Progressive Supranuclear Palsy (PSP-tau) patients, we provide insights into whether phosphorylation of critical residues determine templated tau seeding. Our initial data with …

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Development of a human malaria-on-a-chip disease model for drug efficacy and off-target toxicity evaluation

Michael J. Rupar, Trevor Sasserath, Ethan D. Smith, Brandon Comiter et autres

A functional, multi-organ, serum-free system was developed for the culture of P. falciparum in an attempt to establish innovative platforms for therapeutic drug development. It contains 4 human organ constructs including hepatocytes, splenocytes, endothelial cells, as well as recirculating red blood cells …

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Maternal-neonatal model of immune protection to type 2 pulmonary inflammation

Nandini Krishnamoorthy, Ethan D. Smith, Thayse R. Brüggemann, Katherine H. Walker et autres

Abstract Asthma tends to “run in families” is a concept supported by several research studies of asthma genetics, but this only explains a relatively small fraction of asthma inheritance. We are now standing this paradigm on its head by asking the opposite …

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I Learn to Diffuse, or Data Alchemy 101: a Mnemonic Manifesto

Victor Schetinger, Velitchko Filipov, Ignacio Pérez-Messina, Ethan D. Smith et autres

In this manifesto, we put forward the idea of data alchemy as a narrative device to discuss storytelling and transdisciplinarity in visualization. If data is the prima materia of modern science, how does one perform the Great Work? We use text-to-image diffusion-based …

An Induced Pluripotent Stem Cell‐Derived Neuromuscular Junction Platform for Study of the NGLY1‐Congenital Disorder of Deglycosylation

Trevor Sasserath, Ashley L. Robertson, Roxana Mendez, Tristan T. Hays et autres

There are many neurological rare diseases where animal models have proven inadequate or do not currently exist. NGLY1 Deficiency, a congenital disorder of deglycosylation, is a rare disease that predominantly affects motor control, especially control of neuromuscular action. In this study, NGLY1-deficient, …

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MP17-16 LONG-TERM OUTCOMES FOR PATIENTS WITH ANAPLASTIC BILATERAL WILMS TUMORS ENROLLED ON COG AREN0534

Rodrigo L. P. Romao, Jennifer H. Aldrink, Brett Tornwall, Kathleen Kieran et autres

You have accessJournal of UrologyCME1 May 2022MP17-16 LONG-TERM OUTCOMES FOR PATIENTS WITH ANAPLASTIC BILATERAL WILMS TUMORS ENROLLED ON COG AREN0534 Rodrigo L.P. Romao, Jennifer H. Aldrink, Brett Tornwall, Kathleen Kieran, Andrew Murphy, Andrew Davidoff, Daniel Benedetti, Jeffrey Dome, Elizabeth Perlman, Ethan Smith, …