Quan Vo

Assessment of the influence of Apolipoprotein E on the deposition of Arctic Aβ and seeded deposits in knock‐in and transgenic mouse models

Conner Angelle, Guilian Xu, Andrea Iturbe, Patricia Sacilotto et autres

BACKGROUND: Apolipoprotein E (apoE) facilitates the fibrillization and deposition of amyloid β (Aβ) in Alzheimer's Disease (AD). Supported by robust literature from various groups, in our current study we have investigated the relative amyloidogenic properties of the three major human APOE alleles. …

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Sepsis‐induced systemic inflammation and tau pathology examined in the PS19 transgenic mouse model

Quan Vo, Dina C. Nacionales, Kristi Biswas, Carmelina Gorski et autres

BACKGROUND: Inflammation is a complex biological process that has been shown to be a critical component of the neurodegenerative process in Alzheimer's disease (AD). While intracerebral LPS alters tau pathology in AD mouse models, whether chronic inflammatory signaling from the periphery could …

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Optimization of Preclinical Rodent Research Models of Human Shock: Part One Intra-Abdominal Sepsis

Christine Rodhouse, Zoe Michael, Alexandria Byskosh, Francesco Pinto Boeno et autres

Preclinical models using animals are crucial for medical advancements despite their limitations and criticisms. Critical illnesses like sepsis, trauma, and burns remain huge causes of morbidity and mortality despite medical advances, and human studies may not always be feasible. In this part …

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Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis

Christine Rodhouse, Dayuan Wang, Valerie E. Polcz, Miguel Hernández-Ríos et autres

Sepsis induces profound immune dysregulation, often resulting in chronic critical illness characterized by persistent immunosuppression and poor outcomes. Myeloid-derived suppressor cells (MDSCs) are central mediators of this immunosuppressive phenotype, yet the influence of age and sex on their transcriptional and metabolic states …

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Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits

Guilian Xu, Conner Angelle, Divya Huilgol, Patricia Sacilotto et autres

The Apolipoprotein E (APOE) isoforms APOE2, APOE3 and APOE4 differentially modulate risk of Alzheimer's disease (AD). Despite established evidence for APOE's impact on Aβ deposition, the differential effects of APOE genotypes on distinct forms of amyloid pathology remain poorly understood. The three …

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Acetylation Mimetic and Null Mutations Within the Filament Core of P301L Tau Have Varied Effects on Susceptibility to Seeding and Aggregation

Ethan Smith, Jose Torrellas, Robert W. McKenna, Quan Vo et autres

The two most prominent post-translational modifications of pathologic tau are Ser/Thr/Tyr phosphorylation and Lys acetylation. Whether acetylation impacts the susceptibility of tau to templated seeding in diseases like Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP) is largely uncharacterized. Towards this, we …

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Amyloidogenic SARS-CoV-2 Spike Protein-Derived Peptides Form Oligomers and Selectively Damage Lipid Membranes

Anjola Adewoye, Ephraim Ezeigbo, Quan Vo, Justin Legleiter

Several peptides derived from the SARS-CoV-2 spike protein (S-protein) are amyloidogenic, suggesting a potential role in COVID-19 disease-associated pathogenesis. Many disease-related amyloids form a variety of intermediate oligomeric aggregates and directly damage lipid membranes. Gain of toxic function is commonly observed for …

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Temporal impact of sepsis on Alzheimer's disease pathology and neuroinflammation

Quan Vo, Dina C. Nacionales, Karen N. McFarland, Carmelina Gorski et autres

Epidemiological evidence has revealed an associative link between sepsis survivorship and increased risk of dementia, particularly Alzheimer's disease (AD). Paradoxically, population studies show females are less susceptible to sepsis but more vulnerable to post-sepsis dementia. Here, we examined the temporal impacts of …

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Corrigendum to “Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner” [NeuroImage 305 (2025) 120995]

Quan Vo, Zachary D Simon, Gwoncheol Park, Dina C. Nacionales et autres

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Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner

Quan Vo, Zachary D Simon, Gwoncheol Park, Dina C. Nacionales et autres

Sepsis is a state of systemic immune dysregulation and organ failure that is frequently associated with severe brain disability. Epidemiological studies have indicated that younger females have better prognosis and clinical outcomes relative to males, though the sex-dependent response of the brain …

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Human APOE allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse Apoe in transgenic mouse models of Alzheimer amyloidosis

Guilian Xu, Patricia Sacilotto, C Górski, Parul Bali et autres

Abstract Background Apolipoprotein E (apoE) modulates the deposition of amyloid β (Aβ) aggregates in Alzheimer’s disease (AD) in an isoform-dependent manner. In transgenic mouse models of AD-amyloidosis, replacing mouse Apoe alleles with human APOE variants suppresses fibrillar Aβ deposits. In the PD-APP …

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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

Ethan Smith, Quan Vo, Benoit I. Giasson, David Borchelt et autres

Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated from Alzheimer's disease (AD-tau) or Progressive Supranuclear Palsy (PSP-tau) patients, we provide insights into whether phosphorylation of critical residues determine templated tau seeding. Our initial data with …

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