Chunlu Li

The relationship between childhood emotional neglect and emotional eating: the chain mediating role of alexithymia and difficulties in emotion regulation

Qin Guan, Xiaowei Liu, Chunlu Li, Yongying Yang et autres

Background Emotional eating is prevalent across various weight groups and has a significant impact on individuals’ emotion regulation and healthy eating behaviors. As an early adverse experience, childhood emotional neglect may be associated with greater emotional eating tendencies, potentially through poorer emotion …

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Function-Specific WeChat Use and Loneliness: Problematic Use as a Prospective Pathway in a Two-Wave SEM and CLPN Study

Yuxing Pan, Rong Li, Zhiyu Guo, Chunlu Li et autres

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Identification of TNR as a Potential Hippocampal Biomarker of Novelty Seeking Behavior with Integrated Quantitative Proteomics and Systems Genetics Approaches

Jiahui Liu, Zhaoxi Gu, Hui Li, Quanting Yin et autres

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DNA damage response pathway regulates Nrf2 in response to oxidative stress

Xiao-You Jiang, Qiqiang Guo, Shan-Shan Wang, Yu Feng Zou et autres

Nrf2 acts as a transcriptional master regulator to orchestrate antioxidant responses and maintain redox balance. However, the cellular pathway for translating oxidative stress signals into Nrf2-dependent antioxidant responses remain incompletely understood. Here, we show that reactive oxygen species (ROS) function as signaling …

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Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

Zhuo Wang, Wendong Guo, Xiaowen Zhang, Yufei Wei et autres

T cell exhaustion through the programmed cell death protein 1/PD-L1 interaction pathway. These findings unveil the multifaceted roles and regulatory mechanisms of SIRT1 within the complex TME, providing deeper insights that significantly enhance our understanding of tumor immune-evasion strategies.

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The relationship between perceived stress and bedtime procrastination among Chinese college students: a moderated mediation model

Qiuyue He, Hong Peng Wu, Xiaolu Meng, Chunlu Li

Introduction: the role of stress in inducing bedtime procrastination is a new research topic that has emerged in recent years. This study aimed to explore the psychological mechanism by which perceived stress affects bedtime procrastination in Chinese college students in a life …

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ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment

Ming Bai, Peng Xu, Rong Cheng, Na Li et autres

Hypoxia is an established hallmark of tumorigenesis. HIF-1α activation may be the prime driver of adaptive regulation of tumor cells reacting to hypoxic conditions of the tumor microenvironment. Here, we report a novel regulatory mechanism in charge of the fundamental stability of …

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ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment

Liu Cao, Ming Bai, Peng Xu, Rong Cheng et autres

Sheng Xue Ning as a Novel Agent that Promotes SCF-Driven Hematopoietic Stem/Progenitor Cell Proliferation to Promote Erythropoiesis

Yueying Zeng, Chunlu Li, Fei Yang, Ling Zhang et autres

Stimulating erythropoiesis is essential in the treatment of various types of anemia. Sheng Xue Ning (SXN) is commonly used in China as an iron supplement to treat iron deficiency anemia, renal anemia, and anemia in pregnancy. This research reports a novel effect …

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Resveratrol by elevating the SIRT1 BDNF, GDNF and PSD95 levels reduce heroin addiction related behaviors

Meijun Liu, Chunlu Li, Rongrong Li, Dan Yin et autres

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The effect of perceived stress on binge eating behavior among Chinese university students: a moderated mediation model

Chunlu Li, Jing Gu, Yixin Li, Baijuan Xia et autres

Introduction: Previous studies have demonstrated a strong link between perceived stress and binge eating behavior, but the psychological mechanisms underlying such phenomenon are not fully understood. The present study further addressed this issue in a life history framework, focusing on life history …

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Inhibition of SIRT1 in the nucleus accumbens attenuates heroin addiction-related behavior by decreasing D1 neuronal autophagy

Yanyan Huang, Meijun Liu, Zhiyao Zheng, Ruiping Lu et autres

This study aimed to investigate the effects of SIRT1 modulation on heroin addiction-like behavior and its possible biological mechanisms. Wild-type C57BL/6J and Sirt1loxp/loxp D1-Cre mice were used in this experiment, and Sirt1 loxp/loxp D1-Cre(-) mice were used as a control for conditional …

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