Hanwen Li

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi et autres

ABSTRACT Chordoma is a rare malignant bone tumor characterized by aggressive local invasion and high recurrence, yet its molecular regulatory mechanisms remain poorly understood. Circular RNAs (circRNAs) have emerged as important regulators of gene expression, but how circRNA epigenetic modifications contribute to …

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Biomimetic double-layered electrospun nanofibrous scaffold with mussel adhesive protein coating and TGF-β3 encapsulation for enhanced tendon-bone healing in rotator cuff tears

Sheng Fang, Yuxing Wang, Huan Li, Hanwen Li et autres

Poor tendon-bone healing is a challenging issue and contributes to the high retear rate following rotator cuff tear (RCT) repair. The complex multiple tissue structure and limited chondrogenic capacity at the tendon-bone interface hinder effective regeneration and restoration of the enthesis. In …

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Microenvironment-responsive trilayered bionic periosteum enhances osteogenic-angiogenic coupling for sequential bone regeneration

Xingbang Ruan, Yingchuang Tang, Kai Zhang, Junxin Zhang et autres

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Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

Wenjiao Jiang, Sasa Zhang, Xinyuan Sun, Shun Wang et autres

The intra-adipose NE depletion appears with the development of obesity and its associated metabolic inflammation, owing to the excessive MAOA protein as well as sympathetic neuropathy. GA, the hydrolysate of MGIG, targets TLR4 activation in macrophages to modulate immune-neural communication within adipose …

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Prolonged glucagon exposure rewires lipid oxidation and drives diabetic kidney disease progression

Xingfeng Liu, Jingwen Chen, Shengying Gu, Yibing Chen et autres

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. Tubular abnormalities may precede glomerular pathology and indicate functional progression of DKD. Here, we find glucagon injection exacerbates lipid accumulation and renal injury, in addition to causing morphological changes in …

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Robotic arm target recognition and grasping based on improved YOLOv5s

Qing Luo, Yanwei Feng, Hanwen Li

To enhance the recognition and grasping capabilities of robotic arms for objects, this paper proposes a method based on an improved YOLOv5s model for target detection and pose estimation in robotic grasping. Addressing the challenge of complex background interference in industrial scenarios, …

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Sagittal Classification of Calcified Lumbar Disc Herniation and Therapeutic Analysis of Percutaneous Endoscopic Interlaminar Discectomy

Kai Zhang, Yingchuang Tang, Hanwen Li, Peng Peng et autres

ABSTRACT Background Calcified lumbar disc herniation (CLDH) is one specific type of lumbar disc herniation (LDH). Currently, there are no uniform classification standards for different calcification degrees of herniated lumbar disc tissue. Percutaneous endoscopic interlaminar discectomy (PEID) has been proved to exhibit …

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PZT optical memristors

Chenlei Li, Hongyan Yu, Yaci Zhang, Hengzhen Cao et autres

Optical memristors represent a monumental leap in the fusion of photonics and electronics for neuromorphic computing and artificial intelligence. Here, we reveal the first lead zirconate titanate (PZT) optical memristor, working with a paradigm of functional duality: non-volatile setting and ultrafast volatile …

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The value of super microvascular imaging and shear wave elastography in evaluating synovial lesions in knee osteoarthritis

Min Jin, Lei Mi, Hanwen Li, Fuli Chen et autres

Objective This study investigates the value of super microvascular imaging (SMI) and shear wave elastography (SWE) in evaluating the relationship between synovial tissues and disease severity in knee osteoarthritis (KOA) patients. Materials and Methods Patients with KOA who visited our hospital between …

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Myeloid-derived suppressor cell-targeted virus-like particles synergistically activate innate immune response for cancer immunotherapy

Zhixiong Zhu, Shuqin Cao, Hanwen Li, Zongliang Zhang et autres

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N6‐Methyladenosine‐Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification

Hanwen Li, Yingchuang Tang, Sihan Hu, Xingbang Ruan et autres

Abstract Lumbar instability causes cartilage endplate ossification and intervertebral disc degeneration. In this study, it is determined that circSMAD4, a Yap1‐related circRNA, is stably downregulated under abnormal stress. In vitro, circSMAD4 knockdown resulted in Yap1 mRNA degradation, whereas circSMAD4 overexpression increased Yap1 …

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A Terahertz Imaging Detection System for Cracks in the Outer Ring of All-Ceramic Bearings Based on Image Processing

Hanwen Li, Qi Feng

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