Sasa Zhang

Biomarker-informed PBPK modelling of meropenem in paediatric severe pneumonia: implications for target-site PK/PD

Yao Liu, Sasa Zhang, J. Chen, Jie Zhu et autres

OBJECTIVES: Optimal antimicrobial exposure in epithelial lining fluid (ELF) is critical for meropenem efficacy in pneumonia, yet ELF pharmacokinetic data remain scarce, particularly in children. To address this, we aimed to develop a model capable of predicting meropenem concentrations in both plasma …

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PopPK and PBPK Models Guide Meropenem Dosing in Critically Ill Children with Augmented Renal Clearance

Hua He, Sasa Zhang, Jia Zhou, Jinwei Zhu et autres

Background: Meropenem (MEM) is frequently prescribed for the empirical management of severe infections in the pediatric intensive care unit (PICU). Critically ill children exhibit substantial pharmacokinetic (PK) variability, and current dosing strategies remain inadequately evaluated, particularly in neonates, infants, and those with …

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Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

Wenjiao Jiang, Sasa Zhang, Xinyuan Sun, Shun Wang et autres

The intra-adipose NE depletion appears with the development of obesity and its associated metabolic inflammation, owing to the excessive MAOA protein as well as sympathetic neuropathy. GA, the hydrolysate of MGIG, targets TLR4 activation in macrophages to modulate immune-neural communication within adipose …

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Sanguinarine attenuates Aspergillus fumigatus keratitis by exerting antifungal and anti-inflammatory effects

Junjie Luan, Yun Lu, Qian Wang, Cui Li et autres

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Cedecea selenatireducens sp. nov. and Rahnella selenatireducens sp. nov., isolated from the seleniferous soil

Sasa Zhang, Yi Liu, Haoyang Wang, Jing Peng et autres

Two Gram-stain-negative bacterial strains, designated S5-13T and S5-11T, were isolated from seleniferous soil in Enshi, PR China. Both strains demonstrated the ability to tolerate high concentrations of selenite and selenate and efficiently reduced these selenium oxyanions to elemental selenium. Phylogenetic and phylogenomic …

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PBPK-PD model for predicting pharmacokinetics, tumor growth inhibition, and toxicity risks of topoisomerase inhibitor ADCs in mice and humans

Jinwei Zhu, Lan Sang, Sasa Zhang, Yongmei Tan et autres

• Developed a cross-species PBPK-PD model for predicting PK and PD of TOPI-based ADCs. • Identified key factors affecting PK of ADCs using Sobol′ global sensitivity analysis. • Assessed PFS and hazard ratio in breast cancer patient subgroups treated with ADCs. • …

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Glycoside‐specific metabolomics reveals the novel mechanism of glycinebetaine‐induced cold tolerance by regulating apigenin glycosylation in tea plants

Shan Huang, Sasa Zhang, Xue‐Jing Ma, Xin Zheng et autres

Glycosylation is a key modification that affects secondary metabolites under stress and is influenced by glycinebetaine (GB) to regulate plant stress tolerance. However, the complexity and detection challenges of glycosides hinder our understanding of the regulatory mechanisms of their metabolic interaction with …

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Selenium Nanoparticles Regulate Antioxidant Enzymes and Flavonoid Compounds in Fagopyrum dibotrys

Ting Hu, Sasa Zhang, Kui Li, Yanbin Guo

Fagopyrum dibotrys is a herbal plant. Selenium (Se) is a beneficial element for plants; selenium nanoparticles (SeNPs) are gaining importance in food and agriculture due to their low toxicity and high activity. This study revealed that foliar application of SeNPs enhanced superoxide …

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Selenium nanoparticles affect chicken offspring's intestinal health better than other selenium sources

Yanhong Chen, Sasa Zhang, Zhiqian Hao, Yanbing Guo et autres

This study aimed to assess the effects of maternal diets containing various selenium (Se) sources on the intestinal mucosal function in the jejunum of chicken offspring. A total of 630, 18-wk-old Hy-Line Grey hens and 70 18-wk-old Hy-Line Grey breeders were randomly …

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Bioaccumulation and biotransformation of selenium nanoparticles in soybean and natto, and the bioaccessibility of multi-elements and amino acids

Bingjie Zhao, Sasa Zhang, Kui Li, Yanbin Guo

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Disruption of the cell division protein ftsK gene changes elemental selenium generation, selenite tolerance, and cell morphology in Rahnella aquatilis HX2

Qiaolin Xu, Shanshan Gao, Sasa Zhang, Kui Li et autres

AIMS: Some studies have indicated that the alterations in cellular morphology induced by selenite [Se(Ⅳ)] may be attributed to its inhibitory effects on cell division. However, whether the genes associated with cell division are implicated in Se(Ⅳ) metabolism remains unclear. METHODS AND …

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Identification and Functional Characterization of a Surfactant-like Protein Region in Flagellin FliC for Stabilizing Selenium Nanoparticles and Enhancing Bioavailability

Kui Li, Jingrui Zhang, Sasa Zhang, Qiaolin Xu et autres

Biogenic selenium nanoparticles (SeNPs) are the most favorable Se form for nutritional supplementation due to their high stability, low toxicity, and high activity. However, the interaction between the surface-binding proteins and their stable biogenic SeNPs, as well as their impact on the …

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