Kai Zhang

High-stability, lightweight, ultrathin structured silver/polyetherimide flexible film with Janus wettability and excellent microwave shielding

Kai Zhang, Xiaojuan Lei, Ming Wang

Abstract Herein, we present a strategic approach to fabricate ultra-thin, structured electromagnetic interference (EMI) shielding films with Janus hydrophilic/hydrophobic surfaces, integrating polyetherimide (PEI) microsphere synthesis, silver (Ag) surface deposition, and solvent casting techniques. PEI microspheres with a diameter of ~ 4.78 μm …

Biomechanical design of titanium-PEEK combined fusion cage based on PLIF surgical model

Chunsheng Liu, Yutang Xie, Xinrui Wu, Yanqin Wang et autres

Fusion devices play a critical role in lumbar fusion surgery. Titanium alloy fusion devices offer good biocompatibility and stability, but their mechanical properties far exceed those of bone, leading to stress shielding effects after implantation, which can reduce spinal fusion rates and …

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Exploring the causal relationships between spondyloarthritis/ankylosing spondylitis and intervertebral disc degeneration: a bidirectional Mendelian randomization study

Kexin Qin, Xuejun Wang, Guangzong Ren, Kai Zhang et autres

In this study, we investigated the bidirectional causal relationship between spondyloarthritis (SpA)/ankylosing spondylitis (AS) and intervertebral disc degeneration (IVDD). Genome-wide association study (GWAS) statistics for SpA, AS, and IVDD were obtained exclusively from the FinnGen consortium. The instrumental variables (IVs) were identified …

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Sagittal Classification of Calcified Lumbar Disc Herniation and Therapeutic Analysis of Percutaneous Endoscopic Interlaminar Discectomy

Kai Zhang, Yingchuang Tang, Hanwen Li, Peng Peng et autres

ABSTRACT Background Calcified lumbar disc herniation (CLDH) is one specific type of lumbar disc herniation (LDH). Currently, there are no uniform classification standards for different calcification degrees of herniated lumbar disc tissue. Percutaneous endoscopic interlaminar discectomy (PEID) has been proved to exhibit …

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Three-Dimensional Bioprinted Scaffolds Loaded with Multifunctional Magnesium-Based Metal–Organic Frameworks Improve the Senescence Microenvironment Prompting Aged Bone Defect Repair

Xiang Xu, Xue Zhao, Jie Ma, Tianchang Wang et autres

Age-related bone defects cause disability and mortality in older individuals. During bone repair in older individuals, high oxidative stress and excessive inflammation in the senescent microenvironment (SME) lead to bone marrow mesenchymal stem cell (BMSC) senescence, thereby affecting bone regeneration. In this …

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Biomechanical analysis of posterior, transforaminal, extreme, oblique, and anterior lumbar interbody fusion surgical models: a finite element study

Yutang Xie, Lei Ma, Zhengbiao Yang, Haochen Li et autres

Many lumbar interbody fusion methods have been proposed, but there is a relative scarcity of fundamental biomechanical research on these varied surgical procedures. In this study, a finite element model of an L4-L5 functional spinal unit was created and five interbody fusion …

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Enhanced gut damage and microbial imbalance in bullfrog tadpoles (Lithobates catesbeiana) exposed to polystyrene microplastics under high-temperature conditions

Zhilong Wang, Jun Xie, Guangjun Wang, Huirong Yang et autres

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Inside Back Cover: Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin‐Containing Protein Mediated Autophagy to Attenuate High‐Glucose/High‐Fat‐Induced Intervertebral Disc Degeneration (EXP2 2/2025)

Xiao Yang, Xiankun Cao, Xin Wang, Jiadong Guo et autres

Palladium nanoparticles (Pd NPs) mitigate High-Glucose/High-Fat (or advanced glycation end products, AGEs)-induced intervertebral disc degeneration (IVDD) by facilitating AGEs degradation. They enhance the ATPase activity of Valosin-containing protein (VCP) and promote autophagosome formation, leading to effective AGEs clearance. As a result, Pd …

Surgical techniques for modular one-stage emergent pancreaticoduodenectomy for blunt abdominal trauma: experiences from three centres and a review of the literature

Xing Wang, Zitong Zhang, Zhenwei Shen, Tao Jin et autres

BACKGROUND: In this study, we report the use of a complex surgical intervention termed modular one-stage emergent pancreaticoduodenectomy (MOEPD) for the treatment of acute Grade IV or V pancreaticoduodenal injuries in haemodynamically stable patients. We summarize the experiences of surgeons performing MOEPD …

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Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin‐Containing Protein Mediated Autophagy to Attenuate High‐Glucose/High‐Fat‐Induced Intervertebral Disc Degeneration

Xiao Yang, Xiankun Cao, Xin Wang, Jiadong Guo et autres

Intervertebral disc degeneration (IVDD) is a chronic musculoskeletal disorder causing lower back pain, imposing a considerable burden on global health. Hyperglycemia resulting from diabetes mellitus induces advanced glycation end products (AGEs) accumulation in nucleus pulposus cells, leading to IVDD. Mitigating AGEs accumulation …

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RolePlot: A Systematic Framework for Evaluating and Enhancing the Plot-Progression Capabilities of Role-Playing Agents

Pinyi Zhang, Sojin An, Yifei Yu, Jingyang Chen et autres

Pinyi Zhang, Siyu An, Lingfeng Qiao, Yifei Yu, Jingyang Chen, Jie Wang, Di Yin, Xing Sun, Kai Zhang. Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers). 2025.

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KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

Ouqiang Wu, Yuxin Jin, Zhiguang Zhang, Hao Zhou et autres

Abstract Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence of NPCs remain unknown. In this study, we observed …

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