Xinyuan Sun

Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue

Wenjiao Jiang, Sasa Zhang, Xinyuan Sun, Shun Wang et autres

The intra-adipose NE depletion appears with the development of obesity and its associated metabolic inflammation, owing to the excessive MAOA protein as well as sympathetic neuropathy. GA, the hydrolysate of MGIG, targets TLR4 activation in macrophages to modulate immune-neural communication within adipose …

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The swarmable magnetic-driven nanorobots for facilitating trans-intestinal mucosal delivery of oral vaccines to enhance mucosal and systemic immune responses

Linghong Huang, Xinyuan Sun, Ting Song, Jun Long et autres

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Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits

Linghong Huang, Quan Zhang, Jun Long, Zonghua Liu et autres

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The swarmable magnetic-driven nanorobots for facilitating trans- intestinal mucosal delivery of oral vaccines to enhance mucosal and systemic immune responses

Linghong Huang, Xinyuan Sun, Quan Zhang, Jun Long et autres

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LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer

Xiangling Li, Shilong Jiang, Ting Jiang, Xinyuan Sun et autres

Breast cancer is the most common deadly malignancy in women worldwide. In particular, triple-negative breast cancer (TNBC) exhibits the worst prognosis among four subtypes of breast cancer due to limited treatment options. Exploring novel therapeutic targets holds promise for developing effective treatments …

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Targeting lncRNA DDIT4‐AS1 Sensitizes Triple Negative Breast Cancer to Chemotherapy via Suppressing of Autophagy

Ting Jiang, Jiaojiao Zhu, Shilong Jiang, Zonglin Chen et autres

In this study, it is found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1 (DDIT4-AS1), is highly expressed in triple-negative breast cancer (TNBC) cell lines and tissues due to H3K27 acetylation in the promoter region, and promotes the proliferation, migration, …

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Identification of KCNK1 as a potential prognostic biomarker and therapeutic target of breast cancer

Xinyuan Sun, Yi‐Zhi Li, Hua Lan, Ting Jiang et autres

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RSK2 promotes melanoma cell proliferation and vemurafenib resistance via upregulating cyclin D1

Hai-zhou Wu, Lanya Li, Shilong Jiang, Yi‐Zhi Li et autres

BRAF inhibitors are commonly used in targeted therapies for melanoma patients harboring BRAFV600E mutant. Despite the benefit of vemurafenib therapy, acquired resistance during or after treatment remains a major obstacle in BRAFV600E mutant melanoma. Here we found that RSK2 is overexpressed in …

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Characterization of the m6A-Associated Tumor Immune Microenvironment in Prostate Cancer to Aid Immunotherapy

Zezhen Liu, Jiehui Zhong, Jie Zeng, Xiaolu Duan et autres

The aim of this study was to elucidate the correlation between m6A modification and the tumor immune microenvironment (TIME) in prostate cancer (PCa) and to identify the m6A regulation patterns suitable for immune checkpoint inhibitors (ICIs) therapy. We evaluated the m6A regulation …

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Landscape of microenvironment in Randall’s plaque by single-cell sequencing

Zezhen Liu, Xiaolu Duan, Xinyuan Sun, Jiehui Zhong et autres

Abstract Randall’s plaque is significantly associated with the occurrence of nephrolithiasis. However, the microenvironment of Randall’s plaque is poorly characterized. To investigate the microenvironment of Randall’s plaque, we analyzed single-cell RNA data of 3 Randall’s plaque and 3 normal renal papillae tissue …

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RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKα2-mediated autophagy

Lanya Li, Xisha Chen, Kuan-Song Wang, Yidi Guan et autres

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UCH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer

Xisha Chen, Kuan-Song Wang, Wei Guo, Lanya Li et autres

: Our results reveal an important role of UCH-L1 in modulating ERα status and demonstrate the involvement of UCH-L1-EGFR signaling pathway, suggesting that UCH-L1 may serve as a novel adjuvant target for treatment of hormone therapy-insensitive breast cancers. Targeting UCH-L1 to sensitize …

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