Hao Liang

Time-restricted eating and gut microbiota alpha diversity in adults with overweight or obesity: an updated rapid systematic review

Yibing Melody Zhai, Xinyu Liu, Zeyou Wang, Min Wang et autres

Background Time-restricted eating (TRE) is widely used for weight management, but its effect on gut microbiota alpha diversity in adults with overweight or obesity remains uncertain. Methods We updated a rapid systematic review of intervention studies in adults with body mass index …

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Establish and validate a clinical predictive model for pediatric gastrointestinal endoscopy

Bingyan Zhang, Jing Wu, Lifang Chen, Lianyu Zhou et autres

Aim: Determining appropriate endoscopic referrals in children is challenging due to the lack of validated prediction tools. This study aimed to develop and validate a predictive model to support decision-making in pediatric endoscopy. Methods: This single-center retrospective study included hospitalized children aged …

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CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Yu-Ying Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang et autres

ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting …

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Cytochrome P450-mediated biotransformation of octocrylene in Tetradesmus obliquus: Integrative insights from transcriptomics, proteomics, molecular docking, and density functional theory calculation

Junjie Hu, Chang‐Gui Pan, Xiangrong Xu, Feng‐Jiao Peng et autres

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Temporal Dynamics of Somatic Mutations in Tumor and Plasma Samples From Hepatocellular Carcinoma Patients Pre‐ and Post‐Radioactive Particle Implantation: A Whole‐Exome Sequencing Study

Hongxin Niu, Jian Wang, Huirong Xu, Hao Liang et autres

Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. This study investigates the temporal dynamics of somatic mutations in HCC patients treated with radioactive particle therapy. Using whole-exome sequencing (WES), we track these mutations at different stages: pre-therapy (intra-cancer), post-therapy 1 …

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Shikonin inhibits epithelial-mesenchymal transition in glioblastoma cells by upregulating p53 and promoting miR-361-5p level to suppress ZEB1 expression

Fengying Zhang, Zhiyi Liu, Yingbin Wang, Lin Zuo et autres

OBJECTIVE: Shikonin, an active compound from the rhizome of Lithospermum erythrorhizon, exerts anti-tumor effects in various cancers, including glioblastoma multiforme (GBM). This study explored the mechanism of Shikonin for inhibiting the migration and invasion of GBM cells, providing a rationale for developing …

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An integrated multi-omics approach reveals octocrylene disrupts Tetradesmus obliquus growth by triggering a cascade of photosynthetic inhibition and metabolic dysregulation

Junjie Hu, Chang‐Gui Pan, Feng‐Jiao Peng, Hao Liang et autres

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Single cell transcriptome profiling of immune tissues from germ-free and specific pathogen-free piglet

Jinwei Zhang, Chuang Tang, Yan Liu, Jing Sun et autres

The commensal microbiota provides immunomodulatory signals during the development, differentiation and activation of immune cells, and is crucial for maintaining host immune homeostasis. However, the systematic effects of commensal microbiota on host immunity based on large animal model at the single-cell level …

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CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren et autres

Circular RNAs (circRNAs) are crucial regulators of targeted drug resistance in hepatocellular carcinoma (HCC). However, the specific mechanisms underlying resistance that significantly hampers the effectiveness of HCC treatments remain unclear. Here, it is found that circRNA-mTOR is highly expressed in HCC and …

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Research Progress on the Preparation and Application of Decellularized Tendons

Jing Li, Mingxing Wen, Sujuan Zhang, Lianfang Du et autres

Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the …

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Comprehensive Analysis of Orthodontic Treatment Effects on the Oral Microbiome, Metabolome, and Associated Health Indicators

Qin Xie, Duo Li, Chengyan Ren, Hao Liang et autres

INTRODUCTION AND AIMS: Effects of orthodontic treatments on oral health, particularly on the microbiome and metabolome, are not well understood, and this study aims to clarify these influences using multi-omics approaches. METHODS: We used 16SrRNA sequencing to analyze oral microbiota and untargeted …

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New frontiers in hepatocellular carcinoma: Precision imaging for microvascular invasion prediction

Hao Liang, Zhaonan Zhang, Shuang Han, Shanshan Li et autres

, which underscores the integration of radiomics and clinicoradiological factors to enhance the preoperative prediction of microvascular invasion in patients with hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). The study's use of contrast-enhanced computed tomography radiomics to construct predictive models offers a significant …

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