Jing Sun

Optimization of ecological and efficient restoration technology for green mines based on hesitant fuzzy TOPSIS

Bin Wang, Daoran Guo, Jing Sun, Jian Guo et autres

The geological conditions of mines are complex and diverse, and existing restoration methods may not be sufficient to meet the requirements for all types of mine rehabilitation. A study on the optimization of ecological restoration technologies for green mines based on hesitant …

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933 Preclinical proof-of-concept of an off-the-shelf mRNA cancer antigen therapy targeting pan-tumor antigens for the treatment of multiple solid tumors

LV Xiangmin, Nikhil Khatwani, Glendon S. Wu, Emma N. Goddery et autres

Background mRNA-4106 is a lipid nanoparticle (LNP)-formulated multivalent cancer antigen therapy that encodes seven modified, full-length shared antigens, which are broadly and aberrantly expressed across a range of solid tumors, including melanoma and non-small cell lung cancer. The shared antigen targets in …

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Biogenic jarosite coating as an innovative passivator for acidic uranium residue stabilization using Acidithiobacillus ferrooxidans

Shangze Li, Ling Xiao, Jing Sun, Qian Li et autres

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[Shewanella biofilm formation regulated by acyl-homoserine lactones and its application in UO22+ electrosorption].

Tingting Liu, Hong Shu, Qian Li, Zhao Cui et autres

MR-1 by regulating parameters such as AHL species, concentration, addition time point, and contact time. The results showed that the addition of 10 μmol/L N-butyryl-l-homoserine lactone (C4-HSL) after 6 h of culture and continued incubation to reach the time point of 72 …

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The effects of formula milk on development, nutrient absorption, and immune characteristics of piglets

Chuang Tang, Zhengjiang Liu, Lu Lu, Bo Zeng et autres

Breast milk is widely regarded as the optimal nourishment for infants. However, due to physiological or psychosocial factors, many infants do not receive adequate breastfeeding. So, the formula milk is proposed as a substitute of breast milk, and an increasing number of …

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Facile Synthesis of Magnetic Zn-Coordinated Carbonic Anhydrase Nanozyme Catalyzing CO2 Hydration for Enhanced Sustainable Uranium Extraction

Zhao Cui, Liang Lu, Jing Sun, Qian Li et autres

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Adsorption, transformation, biodegradation and potential ecological toxicity of iron-based nanoparticles in the aqueous environment

Yang Gao, Xiaocheng Wei, Jing Sun, Shaohu Ouyang

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Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets

Jie Chong, Yongming Zhou, Zhijiang Li, Xiaokai Li et autres

Oral bile acids, particularly hyodeoxycholic acid (HDCA), serve as critical drivers for gut microbial community maturation in mice. In the first study, Cy5-labeled HDCA combined with fluorescence imaging revealed rapid gastrointestinal transit of HDCA in piglets, contrasting with its delayed absorption observed …

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First-in-human phase I/II, open-label study of mRNA-2416 alone or combined with durvalumab in patients with advanced solid tumors and ovarian cancer

Ryan Joseph Sullivan, Oladapo Yeku, Deanna K. Teoh, Shilpa Gupta et autres

BACKGROUND: mRNA-2416 is a novel lipid nanoparticle-encapsulated messenger RNA (mRNA) encoding human OX40 ligand (OX40L) for intratumoral (Itu) injection. OX40L plus immune checkpoint inhibitor (ICI) increased preclinical antitumor activity, thus mRNA-2416 plus ICI may potentiate antitumor activity. METHODS: This first-in-human, phase I/II, …

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Single cell transcriptome profiling of immune tissues from germ-free and specific pathogen-free piglet

Jinwei Zhang, Chuang Tang, Yan Liu, Jing Sun et autres

The commensal microbiota provides immunomodulatory signals during the development, differentiation and activation of immune cells, and is crucial for maintaining host immune homeostasis. However, the systematic effects of commensal microbiota on host immunity based on large animal model at the single-cell level …

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Geochemical Study of Trace Elements and In Situ S–Pb Isotopes of the Sachakou Pb–Zn Deposit in the Aksai Chin Region, Xinjiang

Xiaojian Zhao, Nuo Li, Tingbin Fan, Jing Sun et autres

The sulfide Pb–Zn deposits in the Aksai Chin region of Xinjiang have long been subject to debate regarding their genetic classification due to the unclear origin of the ore-forming components. This study focuses on the Sachakou Pb–Zn deposit, the most representative deposit …

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Broccoli ( Brassica oleracea L. var. italica Planch) alleviates metabolic-associated fatty liver disease through regulating gut flora and lipid metabolism via the FXR/LXR signaling pathway

Yingjian Lu, Xin Li, Shaotong Ma, Meng Ding et autres

, and reduce bile acid deposition. In addition, the FXR/LXRα signaling system is impacted by broccoli, which is capable of raising the average levels of expression of the Fxr, SHP, and Cyp7a1 genes and proteins and reducing those of the genes for …

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