Yongchang Tang

Microbial dysbiosis in cholangiocarcinoma

Yunjia Liu, Shaohui Huang, Yang Zhang, Yuankun Zhang et autres

Cholangiocarcinoma (CCA) is a highly aggressive malignancy of the biliary epithelium, with its incidence and mortality rates continuing to rise worldwide. Advances in high-throughput sequencing and metabolomic technologies have intensified interest in elucidating the role of the microbiome in CCA. Microbial dysbiosis …

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The functions of circular RNAs and long noncoding RNAs in cholangiocarcinoma

Zhangdi Yan, Lixin Du, Xiaotong Zhang, Yunjia Liu et autres

Cholangiocarcinoma (CCA) is a highly aggressive malignancy with an extremely poor prognosis. The rising incidence of cholangiocarcinoma in recent years underscores the need for new diagnostic biomarkers and therapeutic targets. Circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) have become important research …

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CircNOX4 promotes proliferation and resistance by regulating the hsa-miR-6884-5p/YWHAG Axis and ERK signaling pathway in cholangiocarcinoma

Zhangdi Yan, Li-xin Du, Yingdi Han, Kangshuai Li et autres

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Bile acids activate cancer-associated fibroblasts and induce an immunosuppressive microenvironment in cholangiocarcinoma

Fan Huang, Zengli Liu, Yan Song, Ganyu Wang et autres

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Exosome-derived lnc-FAM72D-3 promotes lenvatinib resistance by remodeling hepatocellular carcinoma cytoskeleton via MBNL1/FAK axis

Yuxuan Li, Xiaoping Su, Yongchang Tang, Yupeng Ren et autres

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Exosome-derived hsa_circ_0007132 promotes lenvatinib resistance by inhibiting the ubiquitin-mediated degradation of NONO

Mingbo Cao, Yuxuan Li, Xiaoping Su, Yongchang Tang et autres

Hepatocellular carcinoma (HCC) is a highly heterogeneous solid tumor, with its incidence showing a troubling upward trend over the past decade. Lenvatinib is one of the first-line medications for treating advanced HCC, however, the development of resistance significantly undermines its potential to …

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Post-treatment adverse events ranking in targeted immunotherapy for hepatocellular carcinoma: A network meta-analysis based on risk probability assessment

Gaoyuan Yang, Yupeng Ren, Yuxuan Li, Yongchang Tang et autres

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CircRNA‐mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c‐Myc Axis

Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren et autres

Circular RNAs (circRNAs) are crucial regulators of targeted drug resistance in hepatocellular carcinoma (HCC). However, the specific mechanisms underlying resistance that significantly hampers the effectiveness of HCC treatments remain unclear. Here, it is found that circRNA-mTOR is highly expressed in HCC and …

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CircPIK3C3 inhibits hepatocellular carcinoma progression and lenvatinib resistance by suppressing the Wnt/β-catenin pathway via the miR-452-5p/SOX15 axis

Feng Yuan, Yongchang Tang, Hao Liang, Mingbo Cao et autres

INTRODUCTION: Resistance to lenvatinib limits the effectiveness of the targeted treatments for HCC. However, the exact mechanism behind this resistance remains elusive. Current research suggests that circular RNA (circRNA) is pivotal in mediating drug resistance during targeted treatments. OBJECTIVES: To investigate the …

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FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers

Yongchang Tang, Hong Wang, Jiankun Zhang, Chunhui Yang et autres

The crosstalk between cancers and the immune microenvironment plays a critical role in malignant progression. FMS-like tyrosine kinase 3 (FLT3) is a frequently mutated gene in acute myeloid leukemia (AML). However, its role in solid cancers remains poorly understood. We analyzed the …

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Function of histamine-driven cancer-associated fibroblast and hepatocyte growth factor in the progression of cholangiocarcinoma

Xin Wang, Guoli Sheng, Zhangdi Yan, Anda Shi et autres

Abstract Background Here, we aimed to identify the impact of the histamine (HA)–histamine receptor H2 (HRH2) signaling pathway on stimulating the secretion of hepatocyte growth factor (HGF) by cancer-associated fibroblasts (CAFs), as well as elucidating the mechanisms through which HGF promotes the …

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Survival analysis and prognostic nomogram for patients with cholangiocarcinoma after radical resection in Asia

Yongchang Tang, Lei Xu, Gening Zhang, Kangshuai Li et autres

BACKGROUND: CCA has a poor prognosis. Different anatomical subtypes are characterized by distinct clinical features, surgical options, and prognoses, which can potentially impact survival outcomes following radical resection. In addition to the malignancy of CCA itself, clinical staging and treatment methods are …

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