Yunxia Xu

PAXIP1-PAGR1 directs cohesin recruitment during break-induced telomere repair

Soo Yeon Hwang, Xiaoying Wu, Xiangao Huang, Fei Li et autres

Abstract Cohesin is a conserved multiprotein complex (SMC1, SMC3, RAD21, and either STAG1 or STAG2) that organizes three-dimensional genome architecture and regulates chromosome segregation, gene expression, and DNA damage repair 1–4 . Following double-strand breaks (DSBs), cohesin is recruited to sites of …

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Essential and multifunctional mpox virus E5 helicase-primase in double and single hexamer

Yunxia Xu, Yaqi Wu, Yuanyuan Zhang, Kaiting Gao et autres

An outbreak of mpox virus in May 2022 has spread over 110 nonpandemic regions in the world, posing a great threat to global health. Mpox virus E5, a helicase-primase, plays an essential role in DNA replication, but the molecular mechanisms are elusive. …

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Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir

Yunxia Xu, Yaqi Wu, Xiaoying Wu, Yuanyuan Zhang et autres

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Hypergraph-Regularized Lp Smooth Nonnegative Matrix Factorization for Data Representation

Yunxia Xu, Linzhang Lu, Qilong Liu, Zhen Chen

Nonnegative matrix factorization (NMF) has been shown to be a strong data representation technique, with applications in text mining, pattern recognition, image processing, clustering and other fields. In this paper, we propose a hypergraph-regularized Lp smooth nonnegative matrix factorization (HGSNMF) by incorporating …

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Hypergraph Regularized Lp Smooth Nonnegative Matrix Factorization for Data Representation

Yunxia Xu, Linzhang Lu, Qilong Liu, Zhen Chen

Nonnegative matrix factorization (NMF) has been shown to be a strong data representation technique, with applications in text mining, pattern recognition, image processing, clustering and other fields. In this paper, we propose a hypergraph regularized Lp smooth nonnegative matrix factorization (HGSNMF), by …

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Cryo-EM structures of human monkeypox viral replication complexes with and without DNA duplex

Yunxia Xu, Yaqi Wu, Yuanyuan Zhang, Ruixin Fan et autres

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Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice

Yingying Miao, Qin Zhang, Zihang Yuan, Jie Wang et autres

Tripterygium wilfordiimultiglycoside (GTW), extracted and purified from the peeled roots ofT. wilfordiiHook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has been reported to cause severe liver injury. At present, the mechanism underlying GTW-induced …

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Novel application of anti‐human Fc nanobody for screening high‐producing CHO cells for monoclonal antibody

ZHU DI, Zheng Wang, Yunxia Xu, Jing Lin et autres

Animal-derived anti-IgG secondary antibodies are currently employed to stain and screen of human monoclonal antibody(mAb)-producing cells, but using animal-derived antibodies may raise the concerns of high cost, complicated operations and biological safety issues in biopharmaceutical manufacturing. Nanobodies(VHHs) are attractive forms of antibodies …

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Effects of Ambidextrous Leadership on Employees’ Work Behavior: The Mediating Role of Psychological Empowerment

Li Wang, Yuchen Sun, Jinzhi Li, Yunxia Xu et autres

The complexity of today's organizational environment increasingly requires leaders to think in a dynamic and flexible way to resolve contradictory issues. This study explored and compared the effects of servant leadership and authoritarian leadership on employees' work behavior from the perspectives of …

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A Novel Tripartite Evolutionary Game Model for Misinformation Propagation in Social Networks

Xianyong Li, Qizhi Li, Yajun Du, Yongquan Fan et autres

Misinformation has brought great challenges to the government and network media in social networks. To clarify the influences of behaviors of the network media, government, and netizen on misinformation propagation, a large number of influence parameters are proposed for the three participants. …

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How to developed a set of methods for placing a biliary drainage tube through the cystic duct

Yunxia Xu, Huiqiu Guan

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An Improved Model for Short-Term Traffic Forecasting Considering Weather Impacts

Xinchao Chen, Si Alex Qin, Jian Zhang, Huachun Tan et autres

Accurate short-term prediction of traffic conditions on freeways has recently become increasingly important because of its vital role in the basic traffic management functions and trip decision making processes. The objective of this research is to utilize traffic and weather data from …

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