Qin Zhang

A comprehensive review of the new-to-old interface formed between sustainable alkali-activated materials (AAMs) and existing concrete substrate: Bonding strength and mechanism, enhancement strategies, and long-term durability

Guiyan Xiong, Qin Zhang, Andrew B. Cundy, Hui Peng et autres

The aging of global concrete infrastructure has precipitated an urgent demand for efficient repair and rehabilitation strategies. Alkali-activated materials (AAMs) have emerged as a promising alternative to Ordinary Portland Cement (OPC) binders. However, the effectiveness of repaired systems is predominantly governed by …

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Ubiquitination-Mediated Regulation of Brassinosteroid Signaling

Yonghong Xie, Qin Zhang, Juansheng Ren

Brassinosteroids (BRs) are essential steroid hormones that coordinate plant growth, development and adaptation to changing environments. Although BR signaling has long been viewed primarily as a phosphorylation-dependent pathway, increasing evidence shows that ubiquitination provides an additional regulatory layer that shapes the abundance, …

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Machine Learning for Predicting Postoperative Complications After Hypospadias Surgery: A 10-Year Single-Center Retrospective Cohort Study

Li Li, Haosen Shen, Ying Qiu, Baoling Bai et autres

Objectives: Hypospadias is one of the most common congenital malformations of the male genitourinary system, and postoperative complications remain a major concern affecting surgical outcomes and patients‘ quality of life. Whether machine learning models can effectively predict complication risk using routinely available …

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Psoralidin enhances the sensitivity of breast cancer to cisplatin by targeting Nr1i2

Meigong Zhong, Meimei Wu, Ruizhen Chen, Jiadi He et autres

We evaluated the therapeutic effect of psoralidin combined with cisplatin in a mouse model of breast cancer by H&E, immunohistochemistry and TUNEL staining. Transcriptome analysis, bioinformatics analysis and molecular docking analysis were used to explore the mechanism of psoralidin and cisplatin in …

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Supramolecular co-assembly of platycodin-d-loaded iron nanocomposite enhances hepatocellular carcinoma immunotherapy with synergistic ferroptosis–photo-chemotherapy

Kai Chiang Yang, E Ke, Qin Zhang, J Chen et autres

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Cryptococcus detection technologies: An overview of conventional, immunological, and molecular methods, and future development directions

Ziqi Zhao, Simeng Zhang, Yemei Huang, Enqi Zhao et autres

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Research on zoledronic acid’s synergistic improvement of intervertebral disc degeneration and osteoporosis by regulating inflammation matrix microenvironment

Li Wang, Kaiyuan Zheng, Wanhong Luo, Qin Zhang et autres

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Self-constructed Oleanolic acid Pickering emulsions: Oil-regulated bioavailability with intrinsic lipid inhibition

Benyang Li, Qin Zhang, Jie Yu, Chaoxi Zeng

Self-constructed emulsion interface delivery systems (EIDS) based on hydrophobic bioactives represent a novel delivery strategy. Water-in-oil emulsions structured with oleanolic acid (OA) as the Pickering particle significantly enhance OA bioavailability. To further evaluate the efficacy of the EIDS, this study assessed oil …

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Establishment and Characterization of MCA23 , a Novel Mouse Intrahepatic Cholangiocarcinoma Cell Line

Yuchao He, Yi Luo, Li‐Wei Chen, Yu Wang et autres

INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of malignancy. Recent advancements have highlighted the importance of the tumor immune microenvironment in therapeutic responses and prognosis. However, the lack of a mouse-derived ICC cell line and current mouse models limit explorations of …

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Identification of quinazolinone and quinoline alkaloids from Peganum harmala L. inducing mitochondria-mediated apoptosis in liver cancer

Qin Zhang, Jin-Zheng Yu, Chun-Lei Yuan, Fan-Zhu Meng et autres

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Menthol–Fatty Acid HDES Boosts In Vitro Oral Bioavailability of Oleanolic Acid via Synergistic Digestive Release and Cellular Absorption

Qin Zhang, Chenjia Li, Jie Yu, Benyang Li et autres

To improve the oral bioavailability of oleanolic acid (OA), this study developed a menthol-fatty acid-based hydrophobic deep eutectic solvent (HDES) system. Through a comprehensive evaluation using in vitro simulated digestion and Caco-2 cell transport models, the short-chain HDES was found to increase …

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Exogenous Oxytocin Alleviates Prodromal and Clinical Parkinson's Disease Phenotypes via Inhibiting Enteric Glial Cell triggered Neuroinflammation

Hong Chen, Yuanyuan Han, Zhuoting Li, Qin Zhang et autres

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