Jing Xia

Efficacy and safety of sibeprenlimab in IgA nephropathy: interim analysis of the China cohort in the phase 3 VISIONARY trial

Hong Zhang, Adrian Liew, Muh Geot Wong, Deqiong Xie et autres

ABSTRACT Background Immunoglobulin A (IgA) nephropathy is a progressive immune-mediated chronic kidney disease with a high prevalence and disease burden in East Asia, including China. In a prespecified interim analysis (IA) of the global phase 3 VISIONARY trial, treatment with sibeprenlimab led …

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WCN26-6969 EVALUATING SIBEPRENLIMAB IN PATIENTS WITH IgA NEPHROPATHY: RESULTS FROM AN INTERIM ANALYSIS OF THE CHINA COHORT OF THE PHASE 3 VISIONARY TRIAL

Hong Zhang, Adrian Liew, Muh Geot Wong, Deqiong Xie et autres

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WCN26-6808 EFFECT OF SIBEPRENLIMAB ON MICROSCOPIC HEMATURIA IN ADULTS WITH IgA NEPHROPATHY: INTERIM ANALYSIS OF THE “VISIONARY” PHASE 3 TRIAL

H. Suzuki, Vivek Jha, Manuel Praga, Michael Walsh et autres

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The modality specific mechanisms of cross-modal cognitive control in the frontoparietal network

Mengmeng Fu, Jing Xia, Xingxing Zhang, Baoxiang Shang et autres

Cross-modal cognitive control mechanisms, particularly how top-down attention modulates modality-specific processing, remain insufficiently investigated. This study aimed to address this gap by investigating the neural and behavioral correlates of cross-modal conflict resolution. A 2×2×2 hybird-desigen cross-modal flanker paradigm using fMRI was conducted …

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Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial

Vlado Perkovic, Hernán Trimarchi, Vladimı́r Tesař, Richard Lafayette et autres

BACKGROUND: The cytokine A proliferation-inducing ligand (APRIL) is considered a key driver of the pathogenesis of IgA nephropathy. Sibeprenlimab, a humanized IgG2 monoclonal antibody, selectively binds to and inhibits APRIL. METHODS: In this phase 3, multicenter, double-blind, randomized, placebo-controlled trial, we assigned …

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Evaluating Sibeprenlimab in IgA Nephropathy - Rationale and Baseline Data from the VISIONARY Trial

Vlado Perkovic, Jonathan Barratt, Richard Lafayette, Adrian Liew et autres

Introduction Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis and a leading cause of kidney failure worldwide. Treatments that target the underlying immune drivers of the disease to improve long-term patient outcomes are needed. Sibeprenlimab, a selective A Proliferation-Inducing Ligand …

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Sibeprenlimab for the Treatment of IgAN: VISIONARY Phase 3 Interim and Prespecified Subgroup Analyses

Vlado Perkovic, Jonathan Barratt, Richard Lafayette, Adrian Liew et autres

Background: In a prespecified interim analysis of VISIONARY, sibeprenlimab led to a 51.2% (P<0.0001) placebo (PBO)-adjusted reduction in uPCR-24h at 9 mos. We report on uPCR-24h, disease activity, and biomarkers through 12 mos of treatment and across prespecified subgroups. Methods: VISIONARY, a …

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Earlier finish of motor planning in the premotor cortex predicts faster motor command in the primary motor cortex: Human intracranial EEG evidence

Jing Xia, Deshan Gong, Biao Han, Qiang Guo et autres

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N6-methyladenosine RNA landscape in the aged mouse hearts

Jing Xia, Ying-Ming Li, Zhaofu Liao, Jingyu Wu et autres

Objective Cardiac aging is a major risk factor for the development of cardiovascular diseases. Although evidence suggests an association between N6-methyladenosine (m6A) modification and numerous cardiovascular diseases, its role in cardiac aging remains unclear. This study was conducted to elucidate the role …

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Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence

Fang Li, Xiaodong Cui, Yu-qiong Yan, Jing Xia et autres

Vascular senescence serves as a critical pathophysiological foundation for systemic organ aging in humans. Glutaredoxin 1 (Grx1), a key regulator of intracellular redox signaling, plays a critical role in modulating cellular senescence. In this study, we observed significantly reduced Grx1 expression in …

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Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats

Jing Xia, Xiaolin Zhang, Ling Xu, Nan Yan et autres

Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride. Sodium butyrate (NaB), a short-chain fatty acid produced in the intestinal tract, maintains normal mitochondrial function …

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WCN25-499 PATIENT BASELINE CHARACTERISTICS IN THE ONGOING PHASE 3 VISIONARY TRIAL: A RANDOMIZED, PLACEBO-CONTROLLED STUDY OF SIBEPRENLIMAB FOR IMMUNOGLOBULIN A NEPHROPATHY

Richard Lafayette, Hernán Trimarchi, Jonathan Barratt, Kevin Carroll et autres

Immunoglobulin A nephropathy (IgAN), clinically characterized by proteinuria and a progressive decline in kidney function, is the most common primary glomerulonephritis worldwide. The annual global incidence of IgAN is 2.5 cases per 100,000 persons; however, this varies by region and ethnicity (McGrogan, …

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