Ling Xu

Unveiling the underestimated prevalence of HIV, HBV and TB triple infection in Asia, South America, and Africa: a systematic review and meta-analysis

Yinkang Mo, Zihao Fan, Yaling Cao, Ling Xu et autres

BACKGROUND: Human immunodeficiency virus (HIV) is a genus of retroviruses that targets immune cells and may eventually cause immune-deficiency illness. Triple infection of HIV/hepatitis B virus (HBV) /tuberculosis (TB) leads to a worse prognosis than mono-infection. We aimed to unveil the pooled …

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Retraction Note: Paeoniflorin attenuates early brain injury through reducing oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in rats

Tao Wang, Ling Xu, Lei Gao, Lin Zhao et autres

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Uncovering the Critical Role of Cuproptosis in Wilson Disease: Insights Into Potential Therapeutic Targets

Shan Tang, Feng Ren, Wei Hou, Zihao Fan et autres

Wilson disease (WD) is an inherited disorder caused by ATP7B mutations, resulting in toxic copper accumulation primarily in the liver and brain. While copper-induced hepatotoxicity is a hallmark of WD, the mechanisms linking copper overload to liver injury remain unclear. This study …

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RpoB mutation patterns in Rifampicin-resistant tuberculosis: a Jiangxi Province study, 2021–2023

Zhan Qiu Mao, Qing-Chun Zhang, Huilie Zheng, Zhen Qiong Liu et autres

Antimicrobial resistance in Mycobacterium tuberculosis (M.tb) strains presents a significant challenge to global tuberculosis (TB) control efforts. This study was conducted to explore the distribution and prevalence of mutations at various sites within the 81 bp Rifampicin (RIF) resistance-determining region (RRDR) of …

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SAT-050 Knockout of DDX3X promotes liver regeneration through CD36- mediated hepatic lipid accumulation

Ling Xu, Zhenzhen Pan, Zihao Fan, Yaling Cao et autres

WED-003 One-pot assay based on CRISPR/Cas13a technology for HEV RNA point-of-care testing

Ling Xu, Zihao Fan, Xiangying Zhang, Yaling Cao et autres

Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats

Jing Xia, Xiaolin Zhang, Ling Xu, Nan Yan et autres

Long-term exposure to excess sodium fluoride (NaF) can cause chronic fluorosis. Liver, the most important detoxification organ, is the most vulnerable to the effects of fluoride. Sodium butyrate (NaB), a short-chain fatty acid produced in the intestinal tract, maintains normal mitochondrial function …

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Depressed TFAM promotes acetaminophen-induced hepatotoxicity regulated by DDX3X–PGC1α–NRF2 signaling pathway

Sisi Chen, Yaling Cao, Zihao Fan, Ling Xu et autres

BACKGROUND: Acetaminophen (APAP)-induced acute liver injury (AILI) is the most prevalent cause of acute liver failure and mitochondrial dysfunction plays a dominant role in the pathogenesis of AILI. Mitochondrial transcription factor A (TFAM) is an important marker for maintaining mitochondrial functional homeostasis, …

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One‐Pot Assay Based on CRISPR/Cas13a Technology for HEV RNA Point‐of‐Care Testing

Zihao Fan, Ling Xu, Yaling Cao, Tianxu Liu et autres

ABSTRACT Hepatitis E virus (HEV) poses a serious threat to both public health and animal food safety, thereby highlighting the demands for rapid, sensitive, and easy‐to‐use detection. This study aimed to develop a One‐Pot assay using CRISPR/Cas13a for detecting HEV RNA, suitable …

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[Biological variation and analytical performance specification study of erythrocyte and related parameters].

Ling Xu, Hong Lü, Kai Xia Guo, Xiaohui Wang et autres

A BV study protocol for erythrocyte parameters is designed. When the reference intervals differ between genders, BV data should be calculated separately and the lower BV data are recommended for calculating APS; the RCV should be set separately for each gender.

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The cytoplasmic-nuclear transport of DDX3X promotes immune-mediated liver injury in mice regulated by endoplasmic reticulum stress

Zihao Fan, Ling Xu, Yao Gao, Yaling Cao et autres

Abstract Immune-mediated liver injury is a common characteristic of various liver diseases, including autoimmune and viral hepatitis. Here, we investigated the role of DEAD-box helicase 3, X-linked (DDX3X) in immune-mediated liver injury. Liver injury was induced in C57BL/6J mice via concanavalin A …

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FRI-325 DDX3X regulates the functional transition of endoplasmic reticulum stress in the pathogenesis of liver failure

Ling Xu, Zihao Fan, Yao Gao, Yaling Cao et autres