Yu‐Chan Chang

Upconversion nanoplatform unlocks the theranostic potential of Lu-177 radiotherapy via c-MET axis targeting in head and neck squamous cell carcinoma

Kai-Hung Lin, Chun-Yi Wu, Yu‐Chan Chang, Ming‐Hsien Chan

Upconversion nanoparticles (UCNPs) convert tissue-penetrating near-infrared photons into sharp visible emissions, offering background-free optical readouts for deep-tissue imaging. Here we report multilayer NaLuF 4 :Yb,Tm@NaLuF 4 UCNPs that simultaneously act as fluorescent probes and radioisotope precursors. Under 980 nm excitation, the particles …

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Multiverse of phosphorglycerate kinase: Exploring canonical, moonlighting, and tumor microenvironmental functions

Zhao-Jing He, Phi Ngoc Tram, Hee-Do Kim, Cheorl‐Ho Kim et autres

tw, vn, kr (code pays fourni par la source)

Targeting ESR1 restores SQSTM1-dependent autophagy and sensitizes ER-positive breast cancer to oxidative and radiation stress

Yi‐Fang Yang, Zhao-Jing He, Yu-Yu Lin, Cheorl‐Ho Kim et autres

Estrogen receptor-positive (ER⁺) breast cancer is commonly treated with hormone therapy; however, these tumors frequently develop drug resistance and exhibit poor responses to radiotherapy. To investigate the molecular basis of therapy resistance, we explored the role of estrogen receptor alpha (ESR1) in …

tw, kr (code pays fourni par la source)

Regulation of cellular response to energy stress by RNF128 via modulation of AMPK activation

Ying‐Chuan Chen, Pei‐Yao Liu, Yu‐Lung Lin, Yen‐Chun Ho et autres

tw, jp, us, kr (code pays fourni par la source)

RNF128 regulates the adaptive metabolic response to fasting by modulating PPARα function

Yu‐Lung Lin, Pei‐Yao Liu, Yu‐Ling Tsai, Chien‐Ming Lin et autres

Peroxisome proliferator-activated receptor alpha (PPARα) is a crucial transcriptional factor that regulates fatty acid β-oxidation and ketogenesis in response to fasting. However, the mechanisms underlying PPARα function remain unclear. This study identified a novel PPARα-binding protein-RING finger protein 128 (RNF128)-that facilitates PPARα …

tw, gb, kr (code pays fourni par la source)

Matrix Metalloproteinases and Their Inhibitors in the Pathogenesis of Epithelial Differentiation, Vascular Disease, Endometriosis, and Ocular Fibrotic Pterygium

Jun‐Young Park, Yeon‐Woo Choi, Hee-Do Kim, H. T. Kuo et autres

Matrix metalloproteinases (MMPs) are key enzymes involved in the remodeling of the extracellular matrix (ECM) through the degradation of its components in a controlled endoproteolytic manner. Beyond ECM degradation, MMPs also target plasma membrane proteins implicated in signaling cascades and the progression …

kr, tw (code pays fourni par la source)

Abstract 5373: ALDOA reprograms stemness and mitochondrial function in lung cancer by facilitating lactylation of m6A regulators

You-Yu Lin, Zhao-Jing He, Yu‐Chan Chang

Abstract Lactic acid-derived lactylation has recently emerged as a novel post-translational modification (PTM). This modification has been shown to regulate the N6-methyladenosine (m6A) modification mechanism, thereby influencing RNA function. In lung cancer progression, dysfunctional aldolase (ALDOA) forms a positive feedback loop with …

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Abstract 3289: Radiation supports the polarization of M1 macrophages against triple-negative breast cancer cells via the IKZF1 - CCL5 axis

Kuo Han-Hsi, Yu‐Chan Chang

Abstract Triple-negative breast cancer (TNBC), known for its therapeutic challenges and high metastatic potential, is commonly treated with ionizing radiation (IR). In the tumor microenvironment (TME) of TNBC, macrophages occupy a place and are reprogrammed into two main types, M1 and M2, …

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Construction of hot tumor classification models in gastrointestinal cancers

Chien-Jung Huang, Guan‐Ting Liu, Yi-Chen Yeh, Shin‐Yi Chung et autres

BACKGROUND: Gastrointestinal (GI) cancers account for more than one-third of cancer-related mortality, and the prognosis for late-stage patients remains poor. Immunotherapy has been proven to extend the survival of patients at advanced stages; however, challenges persist in patient selection and overcoming drug …

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The correlation between LAG-3 expression and the efficacy of chemoimmunotherapy in advanced biliary tract cancer

Cheng‐Yu Tang, Yi‐Ting Lin, Yi‐Chen Yeh, Shin‐Yi Chung et autres

Abstract In our previous phase II T1219 trial for advanced biliary tract cancer (ABTC), the combination of nivolumab with modified gemcitabine and S-1 exhibited promising efficacy, while the programmed-death-ligand-1 (PD-L1) expression did not predict chemoimmunotherapy efficacy. Lymphocyte-activation-gene-3 (LAG-3), a negative immune checkpoint, …

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Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma

Shin‐Yi Chung, Yi‐Chen Yeh, Chien-Jung Huang, Nai-Jung Chiang et autres

BACKGROUND: Cholangiocarcinoma is a challenging malignancy with limited responses to conventional therapies, particularly immune checkpoint inhibitor therapy. Tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) are key components of the tumor microenvironment (TME) and have been implicated in the immune response to …

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B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis

Tzu‐Hui Hsu, Yu‐Chan Chang, Yi-Yuan Lee, Chi‐Long Chen et autres

Transforming growth factor (TGF)-β signaling is critical for epithelial-mesenchymal transition (EMT) and colorectal cancer (CRC) metastasis. Disruption of Smad-depednent TGF-β signaling has been shown in CRC cells. However, TGF-β receptor remains expressed on CRC cells. Here, we investigated whether the cooperation between …

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