Cheng‐Yu Tang

Precision Oncology in Duodenal Adenocarcinoma: A Case of Metastatic BRAF V600E-mutant Disease Treated with Encorafenib, Cetuximab, Chemotherapy, and Immunotherapy

Yi-Chieh Chen, Yee Chao, Jan-Mou Lee, Cheng‐Yu Tang

Abstract Duodenal adenocarcinoma is a rare malignancy that is often managed with protocols extrapolated from colorectal cancer (CRC) due to limited disease-specific evidence. We present the case of a 28-year-old female with metastatic BRAF V600E-mutant, human epidermal growth factor receptor 2 (HER2)-positive, …

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Circulating miRNAs as potentially predictive biomarkers for chemoimmunotherapy in advanced biliary tract cancer: a post-hoc analysis of the phase II T1219 study

Nai‐Jung Chiang, Cheng‐Yu Tang, Li‐Yuan Bai, Po-Chang Chang et autres

Circulating microRNAs (miRNAs) have not been investigated as predictive biomarkers in patients with advanced biliary tract cancer (ABTC) who received chemoimmunotherapy. In the single-arm phase II T1219 trial, 46 patients with ABTC received first-line nivolumab, gemcitabine, and S-1 treatment. Plasma samples were …

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The correlation between LAG-3 expression and the efficacy of chemoimmunotherapy in advanced biliary tract cancer

Cheng‐Yu Tang, Yi‐Ting Lin, Yi‐Chen Yeh, Shin‐Yi Chung et autres

Abstract In our previous phase II T1219 trial for advanced biliary tract cancer (ABTC), the combination of nivolumab with modified gemcitabine and S-1 exhibited promising efficacy, while the programmed-death-ligand-1 (PD-L1) expression did not predict chemoimmunotherapy efficacy. Lymphocyte-activation-gene-3 (LAG-3), a negative immune checkpoint, …

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Impact of previous S-1 treatment on efficacy of liposomal irinotecan plus 5-fluorouracil and leucovorin in patients with metastatic pancreatic cancer

Cheng‐Yu Tang, Shih‐Hung Yang, Chung‐Pin Li, Yung‐Yeh Su et autres

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MO36-4 Prognostic impact of genetic mutations in unfavorable cancer of unknown primary site

Cheng‐Yu Tang, Hsueh‐Ju Lu, Hsuan Liu, Chi‐Ying F. Huang et autres

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The impact of different gemcitabine-based first-line regimens, gemcitabine plus nab-paclitaxel or S-1, on the efficacy of second-line liposomal irinotecan in patients with metastatic pancreatic cancer

Nai‐Jung Chiang, Cheng‐Yu Tang, Shih‐Hung Yang, Sz-Chi Chiu et autres

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Left Kidney Undifferentiated Spindle Cell Sarcoma with Myeloid Cell Leukemia-1 Amplification: Therapeutic Response to Bortezomib, Venetoclax, and Dexamethasone Therapy

Cheng‐Yu Tang, Chueh‐Chuan Yen

Abstract The overexpression of myeloid cell leukemia-1 (MCL-1) has been identified in numerous hematologic malignancies and solid tumors. Currently, there are no selective MCL-1 inhibitors. Here, we present a case of left kidney undifferentiated spindle cell sarcoma with MCL-1 amplification. The tumor …

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A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years

Cheng‐Yu Tang, Jen‐Fan Hang, Yi‐Ping Hung, Nai‐Chi Chiu et autres

BACKGROUND: The prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors. METHODS: This retrospective single-center cohort study enrolled 68 patients with newly diagnosed …

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Scaling output energy in a diode-end-pumped passively Q-switched laser with a flat–flat resonator

Cheng‐Yu Tang, Ying J. Huang, H. C. Liang, Y. F. Chen et autres

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Efficient Continuous-Wave Self-Raman Nd:KGW Laser With Intracavity Cascade Emission Based on Shift of 89 cm−1

Cheng‐Yu Tang, K. W. Su

We demonstrated a continuous-wave (CW) self-Raman laser with high conversion efficiency by using Nd:KGW as the Raman crystal based on the Raman shift of 89 cm-1. The maximum Raman output power was as high as 0.42 W under the pump power of …

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Comparative Study Between Extracavity and Intracavity Frequency-Doubled Laser at 532 nm: Application for the Deep Ultraviolet Generation at 266 nm

Yu-Jen Huang, Cheng‐Yu Tang, Chun‐Yu Cho, K. W. Su et autres

We construct a reliable actively Q-switched Nd:YVO4laser to comparatively investigate the output performance of the second harmonic generation between the extracavity and intracavity configurations under a similar operated condition. It is experimentally found that the peak power at 532 nm obtained with …

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Efficient Dual-Wavelength Synchronously Mode- Locked Picosecond Laser Operating on the 4 F 3/2 → 4 I 11/2 Transition With Compactly Combined Dual Gain Media

Yu-Jen Huang, Y. S. Tzeng, Cheng‐Yu Tang, Y. F. Chen

A novel concept based on the dual gain media is originally proposed for achieving a compact efficient dual-wavelength synchronously mode-locked diode-end-pumped Nd laser on the4F3/2→4I11/2transition. We theoretically and experimentally realize that the output power ratio between two spectral outputs could be flexibly …

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