Tianshu Zhang

Curculigoside Alleviates CSDS-induced Depressive-like Behavior by Modulating Pyramidal Neuron Excitability and Synaptic Transmission

景玉宏, Tianshu Zhang, Zihao Wei, Huaiyuan Wang et autres

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A cross-sectional study on the associations between serum metal exposure and thyroid hormones in chinese pregnant women

Y C Li, Tianyu Shi, Xinnan Cui, Tianshu Zhang et autres

Prenatal exposure to environmental metals has been increasingly recognized as a crucial factor influencing maternal thyroid function, which plays a vital role in regulating metabolism, maintaining pregnancy, and supporting fetal neurodevelopment. However, the effects of emerging or less-studied metals, such as titanium …

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A prospective for TCR-T therapy in solid tumors: Pushing the boundaries of immunotherapy

Shiyu Wang, Tianshu Zhang, Qian Xiao

T-cell receptor-engineered T (TCR-T) cell therapy stands out as an innovative and promising approach in cancer immunotherapy, particularly for the treatment of solid tumors. This therapy differs from the well-established chimeric antigen receptor (CAR)-T therapy, which has revolutionized the treatment of hematologic …

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S-Doped Fe–N–C Single-Atom Nanozyme with Enhanced Oxidase-Like Activity for Colorimetric Detection of Serotonin

Haoqiang Zhang, Fuying Zhu, Tao Song, Yisong Ju et autres

Serotonin (5-hydroxytryptamine, 5-HT) is a crucial neurotransmitter, the abnormal levels of which are closely associated with various neuropsychiatric disorders and male reproductive dysfunctions. In this study, a sulfur-doped Fe–N–C single-atom nanozyme (S@Fe-CN x ) was successfully synthesized, and its oxidase-like activity and …

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Intranasal delivery of cannabidiol-loaded hypoxic exosomes for targeted treatment of methamphetamine addiction via enhanced brain penetration and neuroinflammation modulation

Tianshu Zhang, Xiaodong Li, Yinghua Peng, Cong Lin et autres

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Gestational diabetes increases preterm membrane rupture risk through elevated hydroxydesmethylpiperine sulfate levels

Ying Li, Rong Lin, Tianshu Zhang, Tianyu Shi et autres

Objectives: Gestational diabetes mellitus (GDM) is a metabolic disorder that increases the risk of premature rupture of membranes (PROM). The link between GDM-associated metabolic dysregulation and PROM remains unclear. This study investigates the underlying metabolic mechanisms to identify potential therapeutic targets for …

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CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell–mediated alloimmunity

Yuta Yamamura, Gianmarco Sabiu, Jing Zhao, Sungwook Jung et autres

Fibroblastic reticular cells (FRCs) are the master regulators of the lymph node (LN) microenvironment. However, the role of specific FRC subsets in controlling alloimmune responses remains to be studied. Single-cell RNA sequencing (scRNA-Seq) of naive and draining LNs (DLNs) of heart-transplanted mice …

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BS-499656-005 CIRCADIAN PATTERN OF VENTRICULAR ARRHYTHMIAS IN GENE-EDITED PORCINE-TO BABOONS CARDIAC XENOTRANSPLANTATIONS

Mahdokht Parsirad, Oneib Khan, Bartley P. Griffith, Avneesh Kumar Singh et autres

Genetically engineered pig heart transplantation in non-human primates

Avneesh Kumar Singh, Corbin E. Goerlich, Tianshu Zhang, Billeta G. T. Lewis et autres

Improvement in gene modifications of donor pigs has led to the prevention of early cardiac xenograft rejection and significantly prolonged cardiac xenograft survival in both heterotopic and orthotopic preclinical non-human primate (NHP) models. This progress formed the basis for FDA approval for …

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Research on denoising method based on temperature and humidity profile lidar

Bowen Zhang, Guangqiang Fan, Tianshu Zhang

Due to the fact that the vibration and pure rotational Raman signals collected by the temperature and humidity profile lidar were 3-4 orders of magnitude weaker than the Mie scattering signal, they were susceptible to electronic and white noise interference, which seriously …

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Geometric Factor Correction Algorithm Based on Temperature and Humidity Profile Lidar

Bowen Zhang, Guangqiang Fan, Tianshu Zhang

Due to the influence of geometric factors, the temperature and humidity profile of lidar’s near-field signal was warped when sensing the air environment. In order to perform geometric factor correction on near-field signals, this article proposes different correction solutions for the Mie …

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Dissecting the Role of the Hydroxyl Moiety at C14 in (+)-Opioid-Based TLR4 Antagonists via Wet-Lab Experiments and Molecular Dynamics Simulations

Jingwei Gao, Cong Zhang, Hangyu Xu, Tianshu Zhang et autres

Toll-like receptor 4 (TLR4) is pivotal as an innate immune receptor, playing a critical role in mediating neuropathic pain and drug addiction through its regulation of the neuroinflammatory response. The nonclassical (+)-opioid isomers represent a unique subset of TLR4 antagonists known for …

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