S-Doped Fe–N–C Single-Atom Nanozyme with Enhanced Oxidase-Like Activity for Colorimetric Detection of Serotonin
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Le résumé fourni par la source
Serotonin (5-hydroxytryptamine, 5-HT) is a crucial neurotransmitter, the abnormal levels of which are closely associated with various neuropsychiatric disorders and male reproductive dysfunctions. In this study, a sulfur-doped Fe–N–C single-atom nanozyme (S@Fe-CN x ) was successfully synthesized, and its oxidase-like activity and catalytic mechanism were systematically investigated. The experimental results indicate that sulfur doping significantly enhanced Fe-CN x oxygen activation capacity and catalytic kinetics by effectively optimizing the electronic structure of the FeN x active centers. Leveraging its superior oxidase-like activity, we developed a H 2 O 2 -free colorimetric sensing method for the highly sensitive and selective detection of 5-HT. The method exhibited a good linear relationship between absorbance and 5-HT concentration in the range of 40 ng/mL to 10 μg/mL, achieving a low limit of detection of 6.0 ng/mL. The successful application of this method for detecting 5-HT in human serum samples demonstrates its great potential for practical use. Furthermore, we established a smartphone-based colorimetric detection platform that quantified 5-HT by correlating its concentration with the grayscale intensity of standard solution images captured by a smartphone. This approach provides a facile strategy for developing point-of-care testing platforms.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- S-Doped Fe–N–C Single-Atom Nanozyme with Enhanced Oxidase-Like Activity for Colorimetric Detection of Serotonin
- Date Crossref
- 27/12/2025
- Éditeur
- American Chemical Society (ACS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Nanjing University of Chinese Medicine pays non établi dans la noticeUniversité ou école supérieure
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Nanjing Drum Tower Hospital Department of Andrology pays non établi dans la noticeÉtablissement de santé
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Second Affiliated Hospital of Nanjing Medical University pays non établi dans la noticeÉtablissement de santé
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Collaborative Innovation Center of Advanced Microstructures pays non établi dans la noticeStructure de recherche
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Nanjing University pays non établi dans la noticeUniversité ou école supérieure
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Department of Andrology pays non établi dans la noticeInstitution
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College of Engineering and Applied Sciences Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
Nanjing University of Chinese Medicine, Department of Andrology — Nanjing Drum Tower Hospital et Second Affiliated Hospital of Nanjing Medical University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.