Xiaodong Li

A novel Pepper aptamer-based biosensor reveals the abnormal elevation of hCES1 in knee joint fluid of patients with rheumatoid arthritis

Chang Dai, Chang Liu, Kun-Jie Bian, Hong-Xia Wang et autres

Proteomic insights into azoospermia: protein differences in testicular tissue between non-obstructive and obstructive azoospermia patients

Zi Wang, Xiaodong Li, Wei-Min Shao, Dong-Xuan Zheng et autres

Non-obstructive azoospermia (NOA) and obstructive azoospermia (OA) are the main classifications of severe male infertility, but the molecular mechanism of NOA remains poorly understood. This study aimed to identify potential biomarkers and pathological mechanisms by comparing the proteomic differences in testicular tissues …

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Spatiotemporal visualization of prolyl endopeptidase in living systems by an enzyme-activatable NIR fluorogenic probe

Guilin Wei, Zhaoyi Zhang, B Wang, Qiang Jin et autres

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Psychological Support and Single‐Session Interventions for Parents of Children With Long‐Term Health Conditions: A Qualitative Service Evaluation

Anna Roach, Xiaodong Li, Camilla A. Hinde, Thomas B. King et autres

RATIONALE: Parents of children with long-term physical health conditions (LTC) experience elevated rates of stress and mental health problems. Existing psychological interventions targeting this population may be effective in improving their mental health, but accessibility is a concern. AIMS AND OBJECTIVES: Given …

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Polysaccharide of Danggui Buxue Decoction Attenuates Colorectal Cancer via Modulating Intestinal Microflora and Metabolites

Min Guo, Dazhi Guo, Jian-Nan Cao, Xiaodong Li et autres

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Discovery of flavonoids as potent inhibitors of CYP1A to alleviate cellular inflammation and oxidative stress induced by benzo[a]pyrene-induced high CYP1A expression

Xiaodong Li, Nanshan Ma, Chun‐Xian He, Li‐Wei Zou et autres

The environmental pollutant benzo[a]pyrene (BaP) can induce cytochrome P450 family 1 subfamily A (CYP1A) or generate metabolic products that disrupt the balance of oxidative stress, triggering inflammatory responses in the lungs and leading to tissue damage. Flavonoids, known for their natural anti-inflammatory …

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Cutaneous Talaromyces marneffei Infection in an Immunocompetent Adolescent: A Case Report

Yue Chen, Xiaodong Li, Chao Bi, Yan Yang et autres

(TM) infection is a rare but potentially fatal deep fungal disease that typically affects immunocompromised individuals in endemic regions. However, an increasing number of cases have been reported in HIV-negative, immunocompetent patients without classical risk factors. We report the case of a …

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Intranasal delivery of cannabidiol-loaded hypoxic exosomes for targeted treatment of methamphetamine addiction via enhanced brain penetration and neuroinflammation modulation

Tianshu Zhang, Xiaodong Li, Yinghua Peng, Cong Lin et autres

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Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics study

Xiangyu Cui, Xiaodong Li, Xin Qi, Dawang Wang et autres

BACKGROUND: Sarcopenia, characterized by progressive muscle loss and functional decline in aging, poses significant health challenges. Sex steroids, such as estradiol and testosterone, have potential therapeutic roles in mitigating muscle degeneration. This study explores the molecular mechanisms and targets of sex steroids …

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Elucidating the correlation between polychlorinated dibenzo-p-dioxins and prostate cancer progression: Insights from gene expression and molecular docking

Fei Lin, Yong Wei, Chaoran Chen, Wen‐Cai Zheng et autres

OBJECTIVE: Polychlorinated dibenzo-p-dioxins (PCDDs) present a significant long-term threat to human health attributable to their toxicological properties, chemical stability and propensity for bioaccumulation. This study seeks to explore the correlation between PCDDs exposure and prostate cancer (PCa) through comprehensive analysis. METHODS: The …

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High-dose romosozumab promoted bone regeneration of critical-size ulnar defect filled with demineralized bone matrix in nonhuman primates

Xiaodong Li, Frank Asuncion, Michael S. Ominsky, Qing‐Tian Niu et autres

Background: Large bone defects are challenging to manage clinically and usually require treatment with bone graft or bone graft substitute. This study evaluated the effect of romosozumab, a sclerostin antibody, in combination with demineralized bone matrix (DBM) on bone regeneration in a …

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Key Transcription Factors: Avenue for Treating Alcoholic Liver Disease

Min Guo, Jian-Nan Cao, Xiaodong Li, Ling Jin

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