Jian Wang

Analyzing the mechanism of rhubarb in the treatment of cervical cancer based on network pharmacology and molecular docking technology

Yingying Xu, Jian Wang, Guodong Chen

To investigate the mechanism of action of rhubarb in the treatment of cervical cancer by computer simulation techniques such as network pharmacology and molecular docking technology. The active ingredients of rhubarb were identified using TCMSP and HERB databases, and active ingredient target …

cn (code pays fourni par la source)

Author response: Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yue Wu, Yuchen Wu et autres

bd, cn (code pays fourni par la source)

Author response: Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yue Wu, Yuchen Wu et autres

Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome metastasis. A series of in …

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yue Wu, Yuchen Wu et autres

Abstract Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome metastasis. A series of …

bd, cn (code pays fourni par la source)

Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions

Li Zhang, Shuai Zhou, Xinyu Li, Yue Ju et autres

Research on kappa-opioid receptor (KOR) regulation of pain and itching has focused primarily on spinal and peripheral levels. However, the role of central KOR in this process, as well as the mechanisms exacerbating negative emotional responses to pain and itching, remains unknown. …

cn (code pays fourni par la source)

Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade

Junxiang Gu, Jian Wang, Hongwei Fan, Wei Yi et autres

Abstract Neuropathic pain causes enduring physical discomfort and emotional distress. Conventional pharmacological treatments often provide restricted relief and may result in undesirable side effects, posing a substantial clinical challenge. Peripheral and spinal redox homeostasis plays an important role in pain processing and …

cn (code pays fourni par la source)

Author response: Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yue Wu, Yuchen Wu et autres

Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome metastasis. A series of in …

bd, cn (code pays fourni par la source)

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yue Wu, Yuchen Wu et autres

Abstract Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome metastasis. A series of …

bd, cn (code pays fourni par la source)

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yuchen Wu, Jing Cheng et autres

Abstract Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis and drug resistance. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome cisplatin …

bd, cn (code pays fourni par la source)

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

Chong Zhang, Zuoyan Zhang, Yuchen Wu, Jing Cheng et autres

Abstract Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, and the prognosis is poor due to distant metastasis. Thus, there is an urgent need to discover novel therapeutic targets and strategies to overcome metastasis. A series of …

cn, bd (code pays fourni par la source)

Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling

Lili Lin, Zhen Chen, Jun Li, Jianye Peng et autres

cn (code pays fourni par la source)

Proanthocyanidins induce analgesic and anxiolytic effects in spared nerve injured mice by decreasing in vivo firing rate of pyramidal cells in the insular cortex

Pan Wang, Hua-Xing Si, Da-Yu Zhu, Ke-Ke Xing et autres

Neuropathic pain is one of the most common symptoms of clinical pain that often accompanied by severe emotional changes such as anxiety. However, the treatment for comorbidity of chronic pain and anxiety is limited. Proanthocyanidins (PACs), a group of polyphenols enriched in …

cn (code pays fourni par la source)