Yue Ju

613 A clinical trial to evaluate the safety and preliminary efficacy results of CAR-macrophage in metastatic HER2-low expressing and HER2-positive solid tumors

Xiushan Yin, Luo Zhang, Qinyao Zhu, Huan Li et autres

Background Macrophages possess robust tumor-infiltrating capabilities. Engineered macrophages (chimeric antigen receptor macrophages, CAR-M) with enhanced targeting specificity and the ability to evade immunosuppressive microenvironments represent a groundbreaking advancement in solid tumor therapy. The mentioned CAR-M is a third generation of CAR-M, incorporating …

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PSMA-targeted CAR-macrophages drive glycolytic reprogramming for enhanced prostate cancer immunotherapy

Yangli Xu, Duoli Xie, Chunhao Cao, Zhuqian Wang et autres

Although chimeric antigen receptor (CAR)-T cells have demonstrated remarkable efficacy against hematologic malignancies, their effectiveness in solid tumors is limited by poor tumor infiltration and severe cytokine release syndrome (CRS). CAR-macrophage (CAR-M) therapy has emerged as a promising alternative, leveraging the innate …

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MedAide: Information fusion and anatomy of medical intents via LLM-based agent collaboration

Dingkang Yang, Jinjie Wei, M. H. Li, Jiyao Liu et autres

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Supraspinal kappa-opioid receptors: new therapeutic strategies for pain, pruritus, and negative emotions

Li Zhang, Shuai Zhou, Xinyu Li, Yue Ju et autres

Research on kappa-opioid receptor (KOR) regulation of pain and itching has focused primarily on spinal and peripheral levels. However, the role of central KOR in this process, as well as the mechanisms exacerbating negative emotional responses to pain and itching, remains unknown. …

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Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy

Huaijin Zheng, Xinzhe Yang, Nan Huang, Shangqin Yuan et autres

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Macrophages are abundant in the tumor microenvironment, making them an attractive target for therapeutic intervention. While current immunotherapies, including immune checkpoint inhibition (ICI) and chimeric antigen receptor T (CAR-T) cells, …

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PSMA-specific CAR-engineered macrophages for therapy of prostate cancer

Yangli Xu, Duoli Xie, Chunhao Cao, Yue Ju et autres

Chimeric antigen receptor (CAR)-modified macrophages (CAR-Ms) are a promising approach for the treatment of solid tumors due to its high infiltration and immune-regulation activity. Prostate cancer is a typical solid tumor associated with highly immunosuppressive microenvironment. To date, the potential application of …

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Enhanced infection efficiency and cytotoxicity mediated by vpx-containing lentivirus in chimeric antigen receptor macrophage (CAR-M)

Yun Gao, Yue Ju, Xiaomeng Ren, Luo Zhang et autres

Genetically modified macrophage infusion has been proven to be a novel treatment for cancer. One of the most important processes in macrophage-based therapy is the efficient transfer of genes. HIV-1-derived lentiviruses were widely used as delivery vectors in chimeric antigen receptor T …

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High-efficiency blood separation utilizing spiral filtration microchannel with gradually varied width

Yue Ju, Zhaoxin Geng, Liangqi Zhang, W. Wang et autres

A hybrid microfluidic separation device that uses the crossflow and the centrifugation effect to separate human plasma from blood cells has been designed and fabricated. The chip mainly consists of the spiral microchannel, which is divided into inner and outer mcirochannels by …

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