Shihua Li

Species-dependent activities of the PINK1–parkin axis

Wei Huang, Kecheng Chen, Jiayi Wen, Tong Zhang et autres

In vitro studies have established that PTEN-induced putative kinase 1 (PINK1) and parkin are central regulators of mitophagy, and loss-of-function mutations in either gene can cause early-onset Parkinson's disease (PD). Although various animal models, including mice and pigs with PINK1 or PRKN …

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Proteomic profiling of cortex and spinal cord in Tau-P301L transgenic cynomolgus macaques

Weien Liang, Bofeng Han, Liyan Wu, Chengxi Wei et autres

Abstract Tau pathology is a defining feature of several neurodegenerative disorders, but reusable proteomic resources from non-human primate tauopathy models remain limited. Here we describe a four-dimensional label-free quantitative proteomic dataset from cortex and spinal cord tissues of wild-type and Tau-P301L transgenic …

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Modeling Tau-Mediated Pathology in Monkey Brain Slices

Mingtian Pan, Qintian Guo, Peisi Huang, Xiang Han et autres

Tau pathology is a hallmark feature of Alzheimer's disease (AD) and is tightly associated with clinical manifestations. No disease-modifying therapy is currently available for AD, partly due to prominent interspecies differences in tau expression patterns between rodents and primates. To facilitate the …

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Multimodal brain cell atlas across the adult macaque lifespan

Xiao Zhang, Guangyao Lai, Xiangyu Guo, Wen Ma et autres

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Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys

Xichen Song, Caijuan Li, Yang Yang, Chunhui Huang et autres

inducible stem cells for the treatment of TDP-43 proteinopathies.

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Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice

Kaili Ou, Xiang Wang, Mingwei Guo, Dandan Li et autres

Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington disease (HD) is characterized by the accumulation of ubiquitinated mutant HTT (huntingtin) in the central nervous system. Ubiquitination of the misfolded proteins, …

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The role of oligodendroglial dysfunction in Huntington's disease

Xinhui Li, Shihua Li, Xiao‐Jiang Li, Huu Phuc Nguyen et autres

Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Research efforts to understand and treat the disease have historically focused on neuronal pathology, but growing evidence underscores the critical role of oligodendrocytes in its pathogenesis. …

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Mutant THAP11 causes cerebellar neurodegeneration and triggers TREM2-mediated microglial activation in mice

Eshu Ruan, Jingpan Lin, Chen Zhao, Laiqiang Chen et autres

Abnormal expansions of the CAG trinucleotide repeat within specific gene exons give rise to polyglutamine (polyQ) diseases, a family of inherited disorders characterized by late-onset neurodegeneration. Recently, a new type of polyQ disease was identified and named spinocerebellar ataxia 51 (SCA51). SCA51 …

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3D reconstruction of hand object based on a single RGB image: integrating anomaly inference and optimizing attention mechanisms

Bing Lv, Yi Zheng, Shihua Li, Demin Liu et autres

Estimating the pose of hand-object interactions from a single RGB image is a complex task because self-obscuration of the hand and occlusion between hand-objects can seriously affect the accuracy of pose estimation. To cope with the above problems, we construct a new …

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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease

Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li et autres

Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors. Numerous therapeutic approaches have been developed based on the genetic causes and potential mechanisms of …

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RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models

Yingqi Lin, Caijuan Li, Yizhi Chen, Jiale Gao et autres

BACKGROUND: HD is a devastating neurodegenerative disorder caused by the expansion of CAG repeats in the HTT. Silencing the expression of mutated proteins is a therapeutic direction to rescue HD patients, and recent advances in gene editing technology such as CRISPR/CasRx have …

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Ribosome-associated pathological TDP-43 alters the expression of multiple mRNAs in the monkey brain

Shihua Li

Cytoplasmic accumulation of TDP-43 is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. While current studies have primarily focused on gene regulation mediated by full-length nuclear TDP-43, the potential effects of cytoplasmic TDP-43 fragments remain less explored. Our …

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