Jing Guo

Inactivated Enterovirus 71 Particle Aggregation Stability: Dynamic Light Scattering Analysis and Stabilizer Identification

Anna Yang, Dongsheng Yang, Deqin Pang, Jie Wu Yang et autres

BACKGROUND: Inactivated enterovirus 71 (EV71) vaccines play a vital role in preventing severe cases of hand, foot, and mouth disease, with their quality and stability determined by the degree of viral particle aggregation. OBJECTIVE: This study aimed to use dynamic light scattering …

Composition and distribution characteristics of acetic acid-related bacteria during the fermentation process of strong-flavor baijiu

Mandlaa Mandlaa, Mengyu Liu, Guojun Ren, Hui‐Qi Qu et autres

Ethyl acetate (EA) has an important impact on the quality of Strong-flavor Baijiu (SFB) and is synthesized from acetic acid (AA) and ethanol by microorganisms during the fermentation process. However, the composition and distribution characteristics of AA-related microorganisms are unclear in the …

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Gastric Signet Ring Cell Carcinoma in a Helicobacter pylori‐Positive 10‐Year‐Old Boy: A Case Report and Literature Review

Xiaoxuan Li, Xinchi Luan, Wenjuan Yu, Shibo Wang et autres

Gastric cancer is rare in pediatric populations, with gastric signet ring cell carcinoma (GSRCC) being an exceptionally infrequent subtype. We report a case of GSRCC in a 10-year-old Chinese boy with no family history of cancer. The diagnosis was established via gastroscopy, …

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Cellular response, persistent humoral response and efficacy elicited by a CV-A16 vaccine candidate in mice

Mi Deng, Jie Wu, Jie E Yang, Lei You et autres

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Development of In Vitro Potency Methods to Replace In Vivo Tests for Enterovirus 71 Inactivated Vaccine (Human Diploid Cell-Based/Vero Cell-Based)

Xuanxuan Zhang, Yi Li, Dan Yu, X.B. Li et autres

BACKGROUND: The three commercial Enterovirus 71 (EV71) inactivated vaccines which have effectively controlled the EV71 pandemic currently rely on inherent variable in vivo potency methods for batch release. To align with 3R (Replacement, Reduction, Refinement) principles and enhance quality control, this study …

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Diagnostic Criteria for Cancer‐Associated Cachexia: Insights from a Multicentre Cohort Study

Zhenyu Huo, Feifei Chong, Na Li, Siyu Luo et autres

BACKGROUND: To explore the association between cachexia, as defined by different diagnostic criteria, and the risk of mortality in individuals with cancer. We also examined which diagnostic criteria are more feasible and appropriate for cancer-associated cachexia in clinical practice. METHODS: A multicentre …

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Cellular Response, Persistent Humoral Response and Efficacy Elicited by a Cv-A16 Vaccine Candidate in Mice

Mi Deng, Jie Wu, Jie E Yang, Lei You et autres

Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation

Anna Yang, Yun Luo, Jie Wu Yang, Tingbo Xie et autres

The enterovirus A71 (EV71) inactivated vaccine is an effective intervention to control the spread of the virus and prevent EV71-associated hand, foot, and mouth disease (HFMD). It is widely administered to infants and children in China. The empty particles (EPs) and full …

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Higher percentage of CD34 + stem cells and elevated efficacy in androgenetic alopecia treatment observed in CGF prepared from 640 nm laser‐pretreated blood: A preliminary study

Jin Gao, Qin Xiao, Yongzhou Lu, Jing Guo et autres

BACKGROUND: Concentrated growth factor (CGF) injection has proven effective in treating androgenetic alopecia (AGA). The primary mechanism of CGF in treating AGA is thought to be the CD34+ stem cells and platelets-associated growth factors being injected into the scalp. CGF efficacy in …

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Autoantibodies, antigen-autoantibody complexes and antigens complement CA125 for early detection of ovarian cancer

Chae Young Han, Jacob S. Bedia, Wei‐Lei Yang, Sarah J. Hawley et autres

BACKGROUND: Multiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125 for early detection of ovarian cancer. METHODS: Twenty six biomarkers were measured in a single panel of sera from women with early stage (I-II) ovarian …

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Molybdenum nanoparticles as a potential topical medication for alopecia treatment through antioxidant pathways that differ from minoxidil

Qin Xiao, Yongzhou Lu, Wei Yao, Chengchen Gong et autres

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Butyrate ameliorated the intestinal barrier dysfunction and attenuated acute pancreatitis in mice fed with ketogenic diet

Xia He, Jing Guo, Jian Feng Shen, Shiman Jiang et autres

Butyrate, a short-chain fatty acid (SCFA), has demonstrated significant efficacy in preventing colitis-associated inflammation. Acute pancreatitis is an acute gastrointestinal disorder characterized by increased systemic inflammation, bacterial translocation, and disrupted intestinal barrier. However, the effects and mechanisms of butyrate in attenuating acute …

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