Huanhuan Xu

CYTOKININ-RESPONSIVE GATA FACTOR 1 negatively regulates ascorbic acid biosynthesis in non-heading Chinese cabbage

Aimei Bai, Xinya Wang, Huanhuan Xu, Zhile Liang et autres

Ascorbic acid (AsA), an essential nutrient for human health predominantly obtained from fresh vegetables and fruits, demonstrates considerable genetic complexity in its accumulation mechanisms. This study investigates the genetic regulation of AsA biosynthesis in non-heading Chinese cabbage (NHCC), a crucial leafy vegetable …

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Natural compound DOCA blocks TNF-α/TNFR-driven NF-κB activation to ameliorate rheumatoid arthritis

Chunxia Gan, Titi Liu, Fei Chen, J Y Li et autres

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that has long been hampered by limited treatment efficacy and significant side effects. Tumor necrosis factor-α (TNF-α) plays a pivotal role in RA pathogenesis by binding to its receptor (TNFR) and activating the …

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Heterostructure‐Engineered TiO 2 ‐TiN Electrocatalyst Boosts Bidirectional Sulfur Redox Kinetics in Magnesium–Sulfur Batteries

Zhengyuan Gao, Huanhuan Xu, Jingwen Tian, Zhiyang Xue et autres

ABSTRACT The sluggish sulfur redox kinetics in magnesium–sulfur (Mg–S) batteries leads to low discharge voltage, poor sulfur utilization, and severe magnesium polysulfides (MgPS) shuttling, limiting their practical energy density. Herein, a heterostructure‐engineered TiO 2 ‐TiN electrocatalyst is rationally constructed and applied to …

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Gene mapping and preliminary functional verification of BcYUCCA6 associated with wrinkled leaf trait in non-heading Chinese cabbage

Zhile Liang, Yingxin Lin, Miaomiao Yang, Boda Chen et autres

Practice and Exploration of Teaching Reform in the Engineering Mechanics Course under the Deep Integration of the “Outcome-Based Education Concept” and Curriculum-Based Ideological and Political Education

Huanhuan Xu, Xiaoqing Hu, Li Gao

As a core course for the Engineering Cost major at Chongqing Institute of Engineering, Engineering Mechanics shoulders the dual mission of cultivating students’ mechanical thinking, engineering practical abilities, and professional qualities. Centered on the deep integration of the outcome-based education (OBE) concept …

A core-shell multifunctional microneedle patch accelerates infected diabetic wound healing

Kang Wei, Lu He, Yiran Shi, Wen Zhang et autres

Diabetic wounds exhibit impaired angiogenesis, drug-resistant bacterial infections, and oxidative damage to the microenvironment, presenting ongoing clinical challenges. In this research, we designed a core-shell structured multifunctional microneedle (MN) array patch (CS-SDFP/HA-Ag@MOF-PAL) to expedite the healing of infected diabetic wounds. The core …

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Loss‐of‐Function Mutation in CER 2‐ LIKE 1 Reduced Accumulation of Cuticular Wax and Susceptibility to Thrips in Welsh Onion

Jiayi Xing, Huanhuan Xu, Mifeng Bai, Yundan Cong et autres

ABSTRACT Cuticular waxes can form a hydrophobic barrier on aerial plant surfaces, which is essential for mediating plant‐environment interactions by providing protection against both biotic and abiotic stresses. In this study, a cuticular wax mutant ( gl ) was identified and characterised …

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TLR4-IN-C34 attenuates the progression of osteoarthritis through inhibiting inflammation, angiogenesis and pain

Kang Wei, Yi Zou, Huanhuan Xu, Hui Liu et autres

Osteoarthritis (OA), a common degenerative articular disease, is symbolized as joint pain and functional impairment. Chronic inflammation, oxidative stress, and chondrocyte apoptosis are characteristics of the OA pathogenesis. Single-cell RNA sequencing (scRNA-seq) and immunofluorescence of human cartilage demonstrated that the Toll-like receptors …

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Isoginkgetin protects chondrocytes and inhibits osteoarthritis through NF-κB and P21 signaling pathway

Mingli Xu, Xi Chen, Shasha Du, Huanhuan Xu et autres

OBJECTIVE: Osteoarthritis (OA) is the most prevalent chronic articular disease in adults. The degree of cartilage degradation and matrix depletion in OA have been substantially connected with chondrocyte inflammatory response. Consequently, pharmacological anti-inflammatory agents provide OA patients a new therapeutic option. Isoginkgetin …

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The regulatory landscape of β-caryophyllene biosynthesis in pak choi

Haibin Wang, Tiantian Han, Yibo Bai, Shuilin Yuan et autres

β-Caryophyllene is a key volatile sesquiterpene involved in plant defense and contributes to the characteristic aroma of pak choi (Brassica campestris). This study aimed to elucidate the regulatory landscape of β-caryophyllene biosynthesis in pak choi to understand the genetic and molecular mechanisms …

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Cryo-EM structure of an activated GPR4–Gs signaling complex

Yitong Ma, Yijie Wang, Mengyuan Tang, Yuan Weng et autres

G protein-coupled receptor 4 (GPR4) belongs to the subfamily of proton-sensing GPCRs (psGPCRs), which detect pH changes in extracellular environment and regulate diverse physiological responses. GPR4 was found to be overactivated in acidic tumor microenvironment as well as inflammation sites, with a …

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MYSM1 attenuates osteoarthritis by recruiting PP2A to deubiquitinate and dephosphorylate RIPK2

Kang Wei, Chuankun Zhou, Zixing Shu, Xingru Shang et autres

Abstract Osteoarthritis (OA), the most prevalent degenerative joint disease, is marked by cartilage degradation and pathological alterations in surrounding tissues. Currently, no effective disease-modifying treatments exist. This study aimed to elucidate the critical roles of Myb-like, SWIRM, and MPN domains 1 (MYSM1) …

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