Liming Zhang

Identification of volatile and non-volatile components of two lemons based on sensory characteristics, electronic sensing evaluation and untargeted metabolomics

B. He, Long Wan, Zhenyu Ni, Luqi Yin et autres

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[Genetic analysis of a case of Miller-McKusick-Malvaux syndrome type 1 caused by CUL7 gene variant and a literature review].

Liming Zhang, Xue Wu, Jianwei Yang, Hongqi Sun et autres

OBJECTIVE: To explore the clinical features, genetic characteristics in a child with Miller-McKusick-Malvaux syndrome (3MS) type 1 caused by CUL7 gene variant. METHODS: A child diagnosed with 3MS type 1 at the Children's Hospital Affiliated to Zhengzhou University in February 2021 was …

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Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy

Jing Ma, Ruijuan Ma, Xueke Zeng, Liming Zhang et autres

BACKGROUND: Platinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor anti-metastatic activity and immunosuppression. Lysosome metabolism is critical for cancer cell migration and invasion, but how it promotes antitumor immunity in tumours …

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Particulate matter promotes the epithelial to mesenchymal transition in human lung epithelial cells via the ROS pathway.

Jun Zhang, Xiaoyan Xu, Ying Liang, Xiaomin Wu et autres

OBJECTS: Epidemiologic studies have linked exposure to airborne pollutant particulate matter (PM) with increased rates of chronic cardiopulmonary diseases, including asthma and idiopathic pulmonary fibrosis (IPF). Several investigations have suggested that the epithelial-to-mesenchymal transition (EMT) may contribute to the complex pathobiology of …

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BMDCs induce the generation of the CD103+CD8+ tissue-resident memory T cell subtype, which amplifies local tumor control in the genital tract

Yuheng Huang, Long Zhou, Hui Zhang, Liming Zhang et autres

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Mechanical Ventilation with Moderate Tidal Volume Exacerbates Extrapulmonary Sepsis-Induced Lung Injury via IL33-WISP1 Signaling Pathway

Shuai Liu, Meihong Deng, Pinhua Pan, Heth R. Turnquist et autres

ABSTRACT: IL-33 and WNT1-inducible secreted protein (WISP1) play central roles in acute lung injury (ALI) induced by mechanical ventilation with moderate tidal volume (MTV) in the setting of sepsis. Here, we sought to determine the inter-relationship between IL-33 and WISP1 and the …

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Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis

Shuqing Jin, Xibing Ding, Chenxuan Yang, Wenbo Li et autres

Abstract Background: The mechanisms by which moderate tidal volume ventilation (MTV) may exacerbate preexisting lung injury remain unclear. We hypothesized that in two hit model (polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of dsRNA and MTV), systemic endotoxemia via gut-lung axis would lead …

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Correction to: WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury

Zhuang Yu, Tingting Wang, Liming Zhang, Xiaohu Yang et autres

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Functional Genetic Polymorphisms in the IL1RL1–IL18R1 Region Confer Risk for Ocular Behçet’s Disease in a Chinese Han Population

Xiao Tan, Qingyun Zhou, Meng Lv, Handan Tan et autres

Single nucleotide polymorphisms (SNPs) in the IL1RL1-IL18R1 region are associated with various immune-mediated diseases. This study was carried out to investigate the causal variant for ocular Behcet’s disease and elucidate its target genes in the IL1RL1-IL18R1 region. Nine candidate functional SNPs were …

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WISP1 and TLR4 on Macrophages Contribute to Ventilator-Induced Lung Injury

Zhuang Yu, Tingting Wang, Liming Zhang, Xiaohu Yang et autres

Abstract Injurious mechanical ventilation has been shown to directly affect pulmonary and systemic immune responses. How these responses propagate or attenuate remains unknown. The goal of this study was to further determine whether toll-like receptor (TLR) 4 and WNT1-inducible signaling pathway protein …

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Excessive activation of NMDA receptor inhibits the protective effect of endogenous bone marrow mesenchymal stem cells on promoting alveolarization in bronchopulmonary dysplasia

Yinyan Yue, Ziqiang Luo, Zhengchang Liao, Liming Zhang et autres

We studied the role of bone marrow mesenchymal stem cells (MSCs) in our established model of bronchopulmonary dysplasia (BPD) induced by intrauterine hypoxia in the rat. First, we found that intrauterine hypoxia can reduce the number of MSCs in lungs and bone …

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Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression

Yuefeng Xia, Jing Chang, Jinfeng Yang, Wen Ouyang et autres

Mechanical ventilation may cause ventilator‑induced lung injury (VILI). Canonical Wnt signaling has been reported to serve an important role in the pathogenesis of VILI. Bioinformatics analysis revealed that canonical and non‑canonical Wnt signaling pathways were activated in VILI. However, the role of …

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