Wen Ouyang

Sanguinarine chloride inducing ferroptosis and downregulating GPX4 expression in liver cancer: An integrated in silico , in vitro and in vivo study

Wen Ouyang, Jianxin Gao, Jing Liu, Lulu Qin et autres

Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been increasingly implicated in the development and progression of liver cancer. Despite sanguinarine chloride (SC) exhibiting antitumor activity in a number of cancer models, whether it modulates ferroptosis …

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Association between triglyceride glucose-body mass index and preeclampsia risk in advanced maternal age pregnant women-a retrospective cohort study

Sulan Huang, Yeping Mo, Hui Ying Peng, Liangqing Ge et autres

There are limited studies on the relationship between triglyceride glucose-body mass index (TyG-BMI index) and preeclampsia risk in advanced maternal age women. The aim of this study was to investigate the association between TyG-BMI index and the incidence of preeclampsia in advanced …

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Higher educational attainment may reduce the risk of delirium by delaying the initiation and reducing the intensity of smoking: a Mendelian randomization study

Si Cao, Youjie Zeng, Minghua Chen, Wen Ouyang et autres

Abstract Purpose Using Mendelian Randomization (MR) analysis, this study aimed to assess any causal effect of educational attainment on the risk of delirium and to determine whether smoking mediates this association. Methods We obtained genome-wide association study (GWAS) summary-level statistics for educational …

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Effects of ciprofol on postoperative delirium and outcomes in older patients undergoing major thoracic surgery: protocol for a multicentre, prospective, single-blinded, randomised controlled study

Hong Pu, Qian Liu, Wen Ouyang, Ailin Luo et autres

INTRODUCTION: Postoperative delirium (POD) is a notable complication in older adults undergoing major thoracic surgery and is associated with poor clinical outcomes. Ciprofol, an innovative sedative known for its haemodynamic stability, holds the potential to lower the risk of POD. However, high-quality …

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Research on the adaptive design of commercial farmhouses from the perspective of rural revitalization: A case study of Yanqing District, Beijing

Wen Ouyang, Zuozheng Shi

Since the implementation of the Rural Revitalization Strategy, the quality of life of rural residents in China has improved significantly. At the same timeSimultaneously, the villagers' demand for housing functions has also undergone a huge change. With the continuous advancement of agricultural …

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Feasibility Study on the Installation of Elevators in Old Residential Buildings in Beijing from the Perspective of dual aging – A case study of Xinjiekou Sub-district in Xicheng District

Wen Ouyang, Zuozheng Shi, Han Cui, Zekun Li

With the continuous evolution of urban and rural construction models in China, the installation of elevators in old residential communities has become a critical public welfare project aimed at enhancing residents' quality of life and improving mobility. Beijing is facing a dual …

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Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inhibiting ferroptosis in ischemic stroke

Youjie Zeng, Ren Guo, Songhua Chen, Yuxin Lin et autres

BACKGROUND: Diacylglycerol O-acyltransferase 1 (DGAT1) is crucial for triglyceride synthesis, yet its role in ischemic stroke remains unclear. This study investigated DGAT1 in ischemic stroke using middle cerebral artery occlusion (MCAO) rat models and highly differentiated PC12 cells subjected to oxygen-glucose deprivation/reoxygenation …

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Identification and functional characterization of hub genes CLTA, EDIL3, HAPLN1, and HIP1 as diagnostic biomarkers and therapeutic targets in thyroid cancer and Hashimoto’s thyroiditis

Tianyu Liu, Dechun Zhang, Wen Ouyang, Rongfang Li et autres

In this study, we sought to identify key molecular players in both thyroid cancer (TC) and Hashimoto's thyroiditis (HT) by analyzing differentially expressed genes (DEGs) and their potential as biomarkers. We utilized datasets from the Gene Expression Omnibus (GEO) database and identified …

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Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial

Yang Mi, Lei Zhou, Ge Long, Xing Liu et autres

Background: Brain energy metabolism disorders, including glucose utilization disorders and abnormal insulin sensitivity, are linked to the pathogenesis of postoperative delirium. Intranasal insulin has shown significant benefits in improving glucose metabolism, insulin sensitivity and cognitive function. However, its impact on postoperative delirium …

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Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner

Wenxiang Qing, Huimin Chen, Xin Ma, Jie Chen et autres

Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic stress. However, the causal relationship and key factors between gut dysbiosis and brain disorders …

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Unraveling the causal impact of smoking and its DNA methylation signatures on cardiovascular disease: Mendelian randomization and colocalization analysis

Si Cao, Youjie Zeng, Ke Pang, Minghua Chen et autres

BACKGROUND: To explore the mechanisms linking smoking to cardiovascular diseases (CVDs) from an epigenetic perspective. METHODS: Mendelian Randomization (MR) analysis was performed to assess the causal effects of smoking behavior and DNA methylation levels at smoking-related CpG sites on nine CVDs, including …

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Effects of Probiotics Combined with Vitamin B6 on Postoperative Neurocognitive Impairment in Elderly Orthopaedic Patients

Yanan Wang, Li Yang, Changyu Zhao, Yuan Le et autres

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