Ling Li

Substance-related fatal motor vehicle crashes in Maryland: a preliminary toxicological analysis (2024–2025)

Nae Won, Stephanie Haddad, Wendy Shields, Stephanie Dean et autres

BACKGROUND: In 2023, Maryland legalized recreational cannabis use; however, understanding of cannabis involvement in motor vehicle crashes (MVCs) remains limited. We examined toxicology findings, including routine cannabis testing, and crash circumstances among drivers fatally injured in MVCs in Maryland. METHODS: We evaluated …

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Protocol to isolate broadly neutralizing monoclonal antibodies against SARS-CoV-2 from human B cells

Xueyan Huang, Maosheng Lu, Ling Li, Zuowei Wang et autres

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ROS-mediated membrane damage and antioxidant imbalance drive apple flesh browning during cold storage

Jihan Wang, Fujun Li, Bingru Li, Ling Li et autres

Introduction: Flesh browning is a major postharvest disorder in apples during cold storage, yet its physiological basis remains unclear. This study examined reactive oxygen species (ROS) metabolism and antioxidant systems in flesh-browning (FB) and normal (FN) tissues of browning apples, compared with …

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Jasmonate‐Activated AaWRKY9 – AabHLH93 / AabHLH93 – AaMYB7 Complexes Balance Artemisinin Biosynthesis in Artemisia annua

Xueqing Fu, Han Zheng, Yaojie Zhang, Ming Yu et autres

Artemisinin, an antimalarial sesquiterpene lactone, is biosynthesized in glandular trichomes of Artemisia annua. Although numerous transcription factors have been demonstrated to regulate artemisinin biosynthesis, the molecular mechanisms underlying the high expression of artemisinin-associated biosynthetic enzyme and transcription factor genes in young leaves …

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Identification and application of cell-type-specific enhancers for the macaque brain

Ling Li, Yiming Huang, Dengyu Lu, Jiqiang Fu et autres

Identification and application of cell-type-specific enhancers for the macaque brain

Ling Li, Yiming Huang, Dengyu Lu, Jiqiang Fu et autres

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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

Dongyang Tang, Shiqi Lin, Jingbo Zhou, Josh Haipeng Lei et autres

Although three proteasome inhibitors are used for liquid tumor treatment, their effectiveness against solid tumors remains inadequate. To address this issue, we employ a drug combination strategy and discover that ammonium tetrathiomolybdate (TM) and AMD3100 can sensitize solid cancer cell lines to …

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A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls

Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang et autres

The ultimate potential of B cells imprinted by ancestral SARS-CoV-2 in developing neutralizing breadth and potency remains to be explored. Here, we longitudinally tracked B cells that recognize the wild-type spike in two individuals who were repeatedly infected by Omicron variants after …

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Use of non-targeted metabolomics to explore metabolic differences between stem cells and callus of Tetraena mongolica

Haihua Li, Ruiping Wang, Jiahe Li, Ling Li et autres

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Discovery of Synergistic Broadly Neutralizing Antibodies Targeting Non-Dominant Epitopes on SARS-CoV-2 RBD and NTD

Hualong Feng, Zuowei Wang, Ling Li, Yunjian Li et autres

Background/Objectives: Identification and characterization of broadly neutralizing monoclonal antibodies from individuals exposed to SARS-CoV-2, either by infection or vaccination, can inform the development of next-generation vaccines and antibody therapeutics with pan-SARS-CoV-2 protection. Methods: Through single B cell sorting and RT-PCR, monoclonal antibodies …

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402: A PBAE/PLGA MICROPARTICLE FOR CO-DELIVERY OF PANOBINOSTAT AND IMMUNE MODULATORY CYTOKINE IL12 TO ENABLE LOCOREGINOAL SUSTAINED COMBINED THERAPY OF PRIMARY LIVER CANCER

Ling Li, Hongzhe Yu, Jordan J. Green, Florin M. Selaru

Obesity affects the association between Serum Klotho and age-related hearing loss: A cross-sectional study

Jingchao Yan, Ling Li, Qing Ye, Taomin Huang

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