Hualong Feng

[Application of percutaneous vertebro-pedicle plasty in osteoporotic vertebral compression fractures].

S He, Hualong Feng, Yuanfei Fu, Huangsheng Tan et autres

OBJECTIVE: To explore the clinical efficacy of percutaneous vertebro-pediculoplasty(PVPP) versus traditional percutaneous vertebroplasty(PVP) in the treatment of osteoporotic vertebral compression fractures (OVCF) of the thoracolumbar spine. METHODS: ,bone mineral density T-value of (-3.21±0.65),and disease course of (10.25±3.57) days. Perioperative indicators,visual analogue scale …

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A rare B cell clonotype imprinted by ancestral SARS-CoV-2 develops cross-sarbecovirus neutralization in immune recalls

Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang et autres

The ultimate potential of B cells imprinted by ancestral SARS-CoV-2 in developing neutralizing breadth and potency remains to be explored. Here, we longitudinally tracked B cells that recognize the wild-type spike in two individuals who were repeatedly infected by Omicron variants after …

cn (code pays fourni par la source)

Discovery of Synergistic Broadly Neutralizing Antibodies Targeting Non-Dominant Epitopes on SARS-CoV-2 RBD and NTD

Hualong Feng, Zuowei Wang, Ling Li, Yunjian Li et autres

Background/Objectives: Identification and characterization of broadly neutralizing monoclonal antibodies from individuals exposed to SARS-CoV-2, either by infection or vaccination, can inform the development of next-generation vaccines and antibody therapeutics with pan-SARS-CoV-2 protection. Methods: Through single B cell sorting and RT-PCR, monoclonal antibodies …

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Breakthrough infection elicits synergistic broadly neutralizing antibodies targeting non-dominant epitopes on RBD and NTD in an individual of inactivated SARS-CoV-2 vaccine

Zuowei Wang, Hualong Feng, Ling Li, Yunjian Li et autres

Abstract Background/Objectives Identification and characterization of broadly neutralizing monoclonal antibodies from individuals exposed to SARS-CoV-2, either by infection or vaccination, can inform the development of next-generation vaccines and antibody therapeutics with pan-SARS-CoV-2 protection. Methods Through single B cell sorting and RT-PCR, monoclonal …

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Ultrasound guidance for intervertebral disc location and paravertebral tissue swelling quantification in a mouse model of intervertebral disc herniation

Yuanfei Fu, Juyi Lai, Hualong Feng, Huangsheng Tan et autres

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A Rare B Cell Clonotype Imprinted by Ancestral SARS-CoV-2 Develops Pan-Sarbecovirus Neutralization in Immune Recalls

Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang et autres

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Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

Zuowei Wang, Ling Li, Ruiping Du, Xixian Chen et autres

Whether Omicron exposures could overcome ancestral SARS-CoV-2 immune imprinting remains controversial. Here we analyzed B cell responses evoked by sequential Omicron infections in vaccinated and unvaccinated individuals. Plasma neutralizing antibody titers against ancestral SARS-CoV-2 and variants indicate that immune imprinting is not …

cn (code pays fourni par la source)

B cells imprinted by ancestral SARS-CoV-2 develop pan-sarbecovirus neutralization in immune recalls

Xixian Chen, Ling Li, Ruiping Du, Zuowei Wang et autres

Abstract A key question on ancestral SARS-CoV-2 immune imprinting is to what extent imprinted B cells can develop neutralizing breadth and potency in immune recalls. Here, we longitudinally tracked B cells recognizing wild-type spike in two individuals, who were sequentially infected by …

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The paravertebral lymphatic system is involved in the resorption of the herniated nucleus pulposus and the regression of inflammation associated with disc herniation

Yuanfei Fu, Zhiming Lan, Ning Li, Lianping Xing et autres

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Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

Zuowei Wang, Ling Li, Ruiping Du, Xixian Chen et autres

Whether Omicron exposures could overcome ancestral SARS-CoV-2 immune imprinting remains controversial. Here we analyzed B cell responses evoked by sequential Omicron infections in vaccinated and unvaccinated individuals. Plasma neutralizing antibody titers against ancestral SARS-CoV-2 and variants indicate that immune imprinting is not …

cn (code pays fourni par la source)

Treatment of degenerative lumbar scoliosis using transforaminal lumbar interbody fusion based on the concept of intervertebral correction

Juyi Lai, Huangsheng Tan, Hualong Feng, Zhiming Lan et autres

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Factors of Intervertebral Disc Rehydration after Percutaneous Endoscopic Lumbar Discectomy

Juyi Lai, Huangsheng Tan, Haokang Li, Jin Li et autres

Abstract Percutaneous endoscopic lumbar discectomy (PELD) is an effective surgical option for lumbar disc herniation (LDH) but is associated with lumbar intervertebral disc rehydration in some patients. However, the incidence of rehydration is not clearly, and only a few studies have discussed …

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