Ruiping Wang

E3 ligase FBXO2-mediated protein stability of insulin receptor regulates adipogenesis and metabolic health in obesity

Yue Xin, Jiaxin Liu, Zhaoyi Zhai, Haofeng Wu et autres

Adipogenesis, a crucial physiological process, serves to safely sequester lipids, thereby preventing lipotoxicity in peripheral organs and preserving metabolic health during obesity. While insulin signaling plays a pivotal role in adipogenesis, regulating factors, especially the braking mechanism governing this process, warrant further …

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Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence

Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian et autres

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here we report the results of a phase II clinical trial (NCT03274258) of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in patients with RMC, with objective response rate as primary outcome. Enrollment was …

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Autonomic nervous system development-related signature as a novel predictive biomarker for immunotherapy in pan-cancers

Cunen Wu, Weiwei Xue, Yuwen Zhuang, Dayue Darrel Duan et autres

Background: Immunotherapy has revolutionized cancer treatment. However, its clinical application remains limited. There is an urgent need for new predictive and prognostic biomarkers that can identify more patients with objective and durable responses and thus, improve the accuracy of prognosis. Methods: A …

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SocialMOIF: Multi-Order Intention Fusion for Pedestrian Trajectory Prediction

Kai Chen, Xiaodong Zhao, Yujie Huang, Guoyu Fang et autres

The analysis and prediction of agent trajectories are crucial for decision-making processes in intelligent systems, with precise short-term trajectory forecasting being highly significant across a range of applications. Agents and their social interactions have been quantified and modeled by researchers from various …

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The bidirectional regulatory effect of TXNRD2 methylation in patients with chronic heart failure and its nonlinear dose-response relationship with key clinical parameters

Ruonan Zhao, Lin Ma, Ruiping Wang, Rongqiang Zhang

OBJECTIVE: The research focused on examining CpG methylation within the TXNRD2 promoter area in chronic heart failure (CHF) patients, aiming to correlate methylation levels with clinical indexes to guide CHF treatment. METHODS: Whole blood samples from 20 CHF patients and 20 healthy …

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Use of non-targeted metabolomics to explore metabolic differences between stem cells and callus of Tetraena mongolica

Haihua Li, Ruiping Wang, Jiahe Li, Ling Li et autres

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Neural Network-based Automated Classification of 18F-FDG PET/CT Lesions and Prognosis Prediction in Nasopharyngeal Carcinoma Without Distant Metastasis

Yuhu Lv, Danzha Zheng, Ruiping Wang, Zhangyongxue Zhou et autres

PURPOSE: To evaluate the diagnostic performance of the PET Assisted Reporting System (PARS) in nasopharyngeal carcinoma (NPC) patients without distant metastasis, and to investigate the prognostic significance of the metabolic parameters. PATIENTS AND METHODS: Eighty-three NPC patients who underwent pretreatment 18 F-FDG …

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SocialMOIF: Multi-Order Intention Fusion for Pedestrian Trajectory Prediction

Kai Chen, Xiaodong Zhao, Yujie Huang, Guoyu Fang et autres

The analysis and prediction of agent trajectories are crucial for decision-making processes in intelligent systems, with precise short-term trajectory forecasting being highly significant across a range of applications. Agents and their social interactions have been quantified and modeled by researchers from various …

Abstract 7475: A comprehensive single-cell atlas of gastric cancer reveals malignant cell state dynamics and plasticity in tumor progression and metastasis

Enyu Dai, Yanshuo Chu, Yang Liu, Ruiping Wang et autres

Abstract Background: Gastric cancer exhibits diverse malignant cell states that contribute to intratumor heterogeneity (ITH), a fundamental factor that drive tumor progression, metastasis, and treatment resistance. While previous single-cell RNA sequencing (scRNA-seq) studies have provided novel insights into ITH in gastric cancer, …

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Abstract 517: YAP-TEAD-mediated tumor suppression and immune modulation of gastric adenocarcinoma by HSP90 inhibition

Katsuhiro Yoshimura, Gengyi Zou, Yibo Fan, Kohei Yamashita et autres

Abstract Heat shock protein 90 (HSP90), a vital chaperone involved in the folding and stabilization of various cellular proteins, regulates key functions in many tumor cells. In the context of gastric adenocarcinoma (GAC), where HSP90's role remains largely unexplored, we aimed to …

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The interaction effect between key autophagy-related biomarkers and HBV/HCV infections on the survival prognosis of hepatocellular carcinoma

Ruiping Wang, Hui Guo, Xiaoni Kou, Rongrong Chen et autres

Aim: This study aimed to investigate the prognostic and diagnostic value of autophagy-related genes (ATGs) in hepatocellular carcinoma (HCC). Methods: The expression profiles of differentially expressed ATGs (DEAs) were extracted from The Cancer Genome Atlas (TCGA), Human Protein Atlas (HPA), International Cancer …

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METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics

Jiahui Jiang, Yunhe Liu, Jiang‐Jiang Qin, Jianfeng Chen et autres

Recent advances in spatial transcriptomics (ST) techniques provide valuable insights into cellular interactions within the tumor microenvironment (TME). However, most analytical tools lack consideration of histological features and rely on matched single-cell RNA sequencing data, limiting their effectiveness in TME studies. To …

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