Dongyang Tang

GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors

Dongyang Tang, Josh Haipeng Lei, Shiqi Lin, Jingbo Zhou et autres

Proteasome inhibitors show limited efficacy against solid tumors. We previously show the combination of Bortezomib with ammonium tetrathiomolybdate (TM) or AMD3100 could inhibit breast cancer growth rely on intact immune system. However, it remains to be explored the broad application of these …

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A miniaturized-tumor culture platform for developing anti-tumor immunotherapies

Yangyang Feng, Ling Li, Josh Haipeng Lei, Yuzhong Peng et autres

Rationale: is essential for investigating tumor-immune interactions and developing effective immunotherapies. However, current culture models often fail to maintain autologous immune cells or support high-throughput testing. To overcome these limitations, we establish and validate a novel miniaturized-tumor culture (MTC) platform. Methods: To …

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Recent progress in cancer multidrug resistance and therapeutic options associated with protein damage response

Fangyuan Shao, Dongyang Tang, Lei Li, X X Xu et autres

Multidrug resistance (MDR) is a common and leading cause of treatment failure and mortality in cancer patient. While numerous biological processes contribute to drug resistance, recent studies have revealed that most anticancer drugs rapidly bind to and damage newly synthesized proteins upon …

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RAD51B-EZH2 axis as a potential therapeutic target for TNBC through cell fate conversion

S. C. Lin, Dongyang Tang, Josh Haipeng Lei, Xiangpeng Chu et autres

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with higher histologic grade, poorer prognosis, and fewer treatment options due to the lack of reliable and effective molecular targets. Using a functional approach with the Sleeping Beauty (SB) transposon …

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Lars2-signaling mediates platinum resistance by accumulating cancer stem cell population and suppressing anti-tumor immunity

Yuqing Wang, Min Deng, Josh Haipeng Lei, Kai Miao et autres

Platinum-based chemotherapy remains a cornerstone of cancer treatment; however, its clinical efficacy is frequently compromised by acquired drug resistance. Our study elucidated a novel resistance mechanism mediated by LARS2 signaling in mammary tumors. Through comprehensive multi-omics analyses of cancer patients, mouse models, …

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Microstructure and mechanical properties of Al-10at% Sc/6061 Al dissimilar diffusion welding

Lu Zhang, Daogao Wu, Xiaowei Zhang, Hongbo Yang et autres

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Proteasome: Role in T Cell Function Regulation

Dongyang Tang, Xiaoran Wu, Josh Haipeng Lei, Yunfeng Qiao et autres

The proteasome plays a pivotal role in proteostasis and is deeply involved in various cellular processes. Currently, three proteasome inhibitors have been used for clinical therapies of liquid cancers with favorable efficacy, however they fail to achieve ideal efficiency in clinical trials …

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Correction: Generating human facial animation by aggregation deep network and low-rank active learning with table tennis applications

Yin Li, Dongyang Tang, Yi Yang

The original version of this Article contained an error in the term “table tennis live streaming” which needs to be updated to “table tennis training and live teaching.” Corrections have been made in the abstract,

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CDK4/6 Inhibition Induces CD8 + T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Lin He, Yuzhong Peng, Jingbo Zhou, Dongyang Tang et autres

Abstract Cyclin‐dependent kinases 4 and 6 (CDK4/6) regulate cell cycle progression from the G 1 to S phase. Recently, CDK4/6 inhibition (CDK4/6i) is demonstrated to enhance antitumor immunity, as evidenced by increased tumor infiltration of CD8 + T cells; however, the mechanism …

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Suppressing protein damage response to overcome multidrug resistance in cancer therapy

Fangyuan Shao, Zongjie Li, Hao Xiao, Yujun Chen et autres

Multidrug resistance is a significant barrier in cancer therapy largely due to poorly understood regulatory mechanisms. Here we reveal that certain anticancer drugs can bind to newly synthesized proteins prior to reaching their canonical targets, resulting in various forms of protein damage. …

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Microstructure and mechanical properties of Al-10at% Sc/6061Al dissimilar diffusion welding

lu zhang, Daogao Wu, Xiaowei Zhang, Hongbo Yang et autres

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Proteasomes suppress anticancer drug-induced cytotoxicity by inhibiting mitochondrial protein import and promoting ROS-BNIP3-mediated mitophagy

Lei Li, Yangyang Feng, Jingbo Zhou, Yuzhong Peng et autres

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