Huimin Li

Naringenin restores osteogenic differentiation in TNF-α-Treated bone marrow mesenchymal stem cells by targeting AKR1B1

Bin He, Feng He, Huimin Li, Leyi Huang

In chronic inflammatory microenvironments, TNF-α disrupts bone remodeling by suppressing osteogenic differentiation in human bone marrow mesenchymal stem cells (hBMSCs), while conventional TNF-α inhibitors lack osteoprotective effects. This study reveals that naringenin counteracts TNF-α-induced osteogenic suppression by potentially targeting AKR1B1 to restore …

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Shikonin reduces hematopoietic stem cells and immune cells in zebrafish embryos by activating the AMPK signaling pathway

Weitao Hu, Huimin Li, Zhangjie Di, Wenwen Zha et autres

cn (code pays fourni par la source)

Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large‐Scale Coverage Neural Recorder

Hongru Liu, Xinyuan Cao, J.-W. Li, Lingyi Zheng et autres

Deciphering neural mechanisms underlying dynamic natural behaviors of freely moving species requires long-term recordings of large-scale brain activities. However, most conventional neural recorders are limited by their weights and measures, electrode coverage, and signal throughput, hindering the dissection of underlying neural mechanisms. …

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Ultrasound-Assisted Salt Penetration in Sauced Duck: Insights from LF-NMR and MRI Combined Analysis

Xiangyu Wang, Chenlan Xia, Huimin Li, Yangying Sun et autres

This study investigated the effect of ultrasound-assisted curing on salt penetration in sauced duck using a combination of low-field nuclear magnetic resonance (LF-NMR) and magnetic resonance imaging (MRI). Ultrasound treatment significantly accelerated salt penetration in duck meat during curing. The salt content …

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Claudin-7 deficiency induces metabolic reprogramming of neutrophils in the colorectal cancer microenvironment

Xiaoqing Liang, Dajin Yuan, Songyun Zhao, Jianbo Zhou et autres

Neutrophils are integral components of the bone marrow and stromal cell network. They express the immune checkpoint molecule PD-L1 and can induce T cell exhaustion, thereby promoting immunosuppression. In this study, we investigated whether tumor-derived Cldn7 deficiency could recruit polymorphonuclear neutrophils (PMNs), …

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The structural and rheological modulations of okra polysaccharides induced by high-speed shear integrated ultrasonic acid extraction

Xu Yang, Hongwei Cao, Huimin Li, Chuyan Li et autres

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Automatic 3D Quantification Of Root Resorption Using Deep Learning

Qianhan Zheng, Yongjia Wu, Huimin Li, Jiaqi Lin et autres

Aim or purpose Orthodontically induced root resorption (OIRR) is a common complication in orthodontic treatment, and this study explores the use of deep learning for accurate, automated quantification and localization of OIRR from CBCT images, addressing the limitations of traditional, time-consuming, and …

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Insights into gastric mixed adenoneuroendocrine carcinoma: a novel comparative study of clinicopathological features and survival outcomes

Huayong Tan, Jing Huang, Gao-Chun Xiao, Junzhi Liu et autres

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare and histologically complex malignancy. Due to its low incidence, data on gastric MANEC (G-MANEC) are limited, and its clinicopathological characteristics and prognosis remain poorly defined. In this study, we performed a retrospective analysis of 168 …

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Immediate versus staged complete revascularization in patients with acute coronary syndrome and multivessel disease: a meta-analysis of randomized controlled trials

Lin He, Bin Sun, Jing Hu, Huimin Li et autres

Background A series of trials have confirmed that complete revascularization is more beneficial for patients with acute coronary syndrome (ACS) and multivessel disease than culprit-only revascularization. However, the optimal timing of complete revascularization remains controversial. It is unclear whether immediate complete revascularization …

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GM-CSF-adjuvanted Newcastle disease virus-vectored bivalent vaccine elicits enhanced dual immunity against Newcastle disease and infectious bursal disease in chickens

Qing Wu, Jinmiao Liu, Jiayan Li, Huimin Li et autres

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Diagnosis of Cytomegalovirus infection in a very low birth weight infant using metagenomic next-generation sequencing: A case report

Chunhui Zhao, Huimin Li, Li Guo, Menghan Jia et autres

RATIONALE: Cytomegalovirus (CMV) is a DNA virus from the herpesvirus family that is widespread among humans. Very low birth weight infants (VLBWI) are particularly susceptible to postnatal CMV infection due to their compromised immune systems. The clinical manifestations of postnatal CMV infection …

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Landscape of Cardiac Substructure Dose Reduction with IMPT vs. IMRT and Estimated Cardiac Toxicity Difference Using Two NTCP Models in Breast Cancer Patients Receiving Postoperative Radiotherapy

Lixue Cao, Shihua Zhao, S. Zhang, Kai Liao et autres