Dajin Yuan

Claudin-7 deficiency induces metabolic reprogramming of neutrophils in the colorectal cancer microenvironment

Xiaoqing Liang, Dajin Yuan, Songyun Zhao, Jianbo Zhou et autres

Neutrophils are integral components of the bone marrow and stromal cell network. They express the immune checkpoint molecule PD-L1 and can induce T cell exhaustion, thereby promoting immunosuppression. In this study, we investigated whether tumor-derived Cldn7 deficiency could recruit polymorphonuclear neutrophils (PMNs), …

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Identification of hub genes related to radiosensitivity and prognosis in rectal cancer

Hui Yang, Yin Liu, Mengdi Hao, Huimin Li et autres

Background: Radiotherapy is one of the main treatment methods for rectal cancer (RC). However, radioresistance often leads to treatment failure and poor prognosis. This study aimed to explore the core molecules associated with radiosensitivity and prognosis of RC. Methods: GSE133057 containing RC …

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Exploring mechanisms of britannin against colorectal cancer based on experimentally validated network pharmacology

Xiaoli Liu, Qiuxia Ye, Mengdi Hao, Huimin Li et autres

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Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis

Huimin Li, Yin Liu, Meng-Di Hao, Xiao-Qing Liang et autres

BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Over the past two decades, numerous researchers have provided important evidence regarding the role of tight junction (TJ) proteins in the occurrence and …

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Intestinal epithelial Cldn-7 regulates intestinal inflammation by altering the gut microbiota

Huimin Li, Kun Wang, Mengdi Hao, Yin Liu et autres

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Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling

Kun Wang, Yin Liu, Huimin Li, Xiaoqing Liang et autres

Abstract Intestinal stem cells (ISCs) play a crucial role in the continuous self-renewal and recovery of the intestinal epithelium. In previous studies, we have revealed that the specific absence of Claudin-7 (Cldn-7) in intestinal epithelial cells (IECs) can lead to the development …

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The role of intestinal microecology in inflammatory bowel disease and colorectal cancer: A review

Huimin Li, Kun Wang, Mengdi Hao, Yin Liu et autres

Intestinal microecology is a dominant and complex microecological system in human body. Generally, intestinal microecosystem consists of normal symbiotic flora and its living environment (including intestinal epithelial tissue and intestinal mucosal immune system). Commensal flora is the core component of microecology. Both …

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Clinical outcomes of parenchymal-sparing versus anatomic resection for colorectal liver metastases: a systematic review and meta-analysis

Kun Wang, Yin Liu, Mengdi Hao, Huimin Li et autres

BACKGROUND: The advantages of parenchymal-sparing resection (PSR) over anatomic resection (AR) of colorectal liver metastases (CRLM) remain controversial. Here, we aim to evaluate their safety and efficacy. METHODS: A systematic review and meta-analysis of short-term perioperative outcomes and long-term oncological outcomes for …

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Construction and validation of prognostic risk model based on radiosensitivity-related immune genes in rectal cancer

Hui Ying Yang, Yin Liu, Xiaofeng Mu, Kun Wang et autres

Abstract Background Radiotherapy is closely related to the tumor immune microenvironment, but the role of immune genes in radiosensitivity and prognosis of rectal cancer (RC) is still unclear. This study aims to construct a prognostic risk model based on radiosensitivity-related immune genes …

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