Chao Wang

Characterizing choroid plexus cyst burden across the Alzheimer’s disease continuum

Kaicheng Li, Wei Qian, Shuyue Wang, Zhe Sun et autres

BACKGROUND: Choroid plexus (ChP) is responsible for producing cerebrospinal fluid, which is increasingly recognized as important in the context of aging and Alzheimer’ disease (AD). However, structural alteration (especially cystic alteration) of ChP across the pathologically confirmed AD continuum remains unclear. MATERIALS …

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Increased free water in the nucleus basalis of Meynert is associated with worse olfaction in idiopathic Parkinson’s disease

Kai Wei, Shuyue Wang, Cheng Zhou, Chao Wang

Background The association of cholinergic degeneration and olfactory function in Parkinson’s disease (PD) is unclear. Using free water imaging, this study aims to investigate the association between the nucleus basalis of Meynert (NBM) degeneration and olfactory function in patients with PD. Methods …

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Quantitative analysis of enhanced CT in predicting microvascular invasion and pathological grading of hepatocellular carcinoma

Dan Shi, 千津子 谷口, Haiyan Chen, Jieyu Chen et autres

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LRRK2 mutation contributes to decreased free water in the nucleus basalis of Meynert in manifest and premanifest Parkinson’s disease

Chao Wang, Shuyue Wang, Cheng Zhou, Peiyu Huang

Motivation: Brain cholinergic function has not been investigated to date in LRRK2 mutation carriers with or without PD using free-water imaging. Goal(s): To investigate the effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of PD using free-water …

Age-related variations in T1/T2 ratios and perfusion in the deep gray matter nuclei: An MRI study of healthy individuals

Miaoqi Zhang, Chao Wang, Zhe Sun, Chenyang Li et autres

Motivation: It remains unclear about MRI signal intensity (i.e. T1/T2 ratio) and perfusion changes during aging, and the relationship between T1/T2 ratio and perfusion in deep gray matter nuclei (DGMN). Goal(s): Systematically exploring the changes of T1/T2 ratio, CBF and ATT during …

Photon-Counting CT Accurately Distinguishes Iodine Contrast Extravasation and Hemorrhage: A Case Series Study

Shuyue Wang, Shuangxiang Lin, Jianzhong Sun, Zhicai Chen et autres

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Postoperative microcystic meningioma of the fourth ventricle with subsequent giant cell reparative granuloma: a case report

Fangfang Xu, Cuiping Fu, Qian Li, Fei Dong et autres

Background Microcystic meningioma (MM) is a distinctive benign tumor typically located in the supratentorial region. Giant cell reparative granuloma (GCRG) is another rare reactive benign lesion associated with surgical trauma or tissue injury. The occurrence of MM in the fourth ventricle is …

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Assessment of diffusivity along the perivascular space in early- and late-onset Alzheimer's disease

Xiao Luo, Hui Hong, Shuyue Wang, Kaicheng Li et autres

BackgroundCerebrospinal fluid (CSF) dynamics plays a key role in clearing soluble amyloid-β from the brain, which may impact Alzheimer's disease (AD) onset.ObjectiveThis study seeks to differentiate cerebrospinal fluid dysfunction between early-onset AD (EOAD) and late-onset AD (LOAD) subtypes and to examine their …

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Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B

Chi Chen, Yan Gu, Junfei Xu, Yanyan Xiao et autres

Apolipoprotein B (apoB) can be measured directly and accurately, and better predicts atherogenic risk than conventional lipid profiles. We aimed to investigate whether total and regional (trunk or leg) fat deposits are associated with apoB levels in general US adults. 4585 participants …

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Hippocampal subfields in aging: Sex-specific trajectories in structure and hemodynamics

Chenyang Li, Zhe Sun, Chao Wang, Jiangyang Zhang et autres

Sex differences in hippocampal aging have been increasingly recognized, with females showing greater vulnerability to neurodegeneration, particularly after menopause. However, the underlying neurobiological mechanisms remain unclear, especially at the level of hippocampal subfields. Leveraging high-resolution T1-, T2-weighted, and multi-delay arterial spin labeling …

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Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum

Shuyue Wang, Fan Zhang, Qingze Zeng, Hui Hong et autres

Background and Objectivesβ-amyloid (Aβ) and tau, 2 prominent pathologies of Alzheimer disease (AD), originate in cortical regions and primarily affect, and even spread along, the white matter tracts directly connected to these cortical regions. Superficial white matter (SWM), containing short-range association connections …

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Deciphering the role of liver metabolic enzymes in dementia pathogenesis

Kaicheng Li, Jingyun Zhang, Hui Hong, Yeerfan Jiaerken et autres

The relationship between liver metabolic enzymes and the risk of dementia, as well as whether genetic factors can explain these potential associations, remains unclear. Based on data from 347,605 dementia-free British adults in the UK Biobank, we categorized participants into normal and …

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