Xiao Luo

Detection of Trichophyton indotineae using a species-specific genomic marker: a marker identification and assay validation study

Chao Tang, Yuhan Zhang, Ricardo Belmonte-Lopes, Jochem Buil et autres

BACKGROUND: Trichophyton indotineae is an emerging dermatophyte associated with extensive inflammatory tinea and terbinafine resistance. Routine laboratory methods often fail to distinguish T indotineae from related lineages in the Trichophyton mentagrophytes-interdigitale complex, hindering surveillance and delaying resistance testing. We aimed to define …

nl, cn, ir, de, br, sg (code pays fourni par la source)

Association Between Choroid Plexus Morphological Alterations, Alzheimer Pathologies, and Cognitive Impairment

Qingze Zeng, Siyan Zhong, Shaoping Nie, R. Zhang et autres

BACKGROUND AND OBJECTIVES: The choroid plexus (ChP) plays a crucial role in maintaining brain health. Alzheimer disease (AD) pathologies may damage the ChP and accelerate neurodegeneration. Previous imaging studies have found overall increased ChP volume in patients with AD. In this study, …

cn (code pays fourni par la source)

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Ke Gai, Yu Song, Dawen Gao, Qing Nie et autres

Alzheimer's disease (AD) is a neurodegenerative disorder that lacks effective treatments and urgently requires innovative therapeutic strategies. Although stem cell therapy has demonstrated efficacy in preclinical and clinical studies, it faces challenges such as low cell survival (<5%) and uncontrolled glial differentiation. …

cn (code pays fourni par la source)

Free water, perivascular spaces, and diffusivity along perivascular spaces dynamics after recent small subcortical infarcts and their associations with cognition

Tiantian Qiu, Hui Hong, Xiaopei Xu, Yuan Xu et autres

Background and Purpose: The pathophysiological mechanisms underlying cognitive changes following recent small subcortical infarcts (RSSIs) remain incompletely understood. In this study, we aimed to investigate alterations in brain fluid dynamics—including interstitial fluid (ISF) and perivascular space (PVS) abnormalities—using magnetic resonance imaging (MRI)-based …

cn (code pays fourni par la source)

Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate?

Qing Zhao, Xiao Luo, Xing Hua, Chengwei Jiang et autres

Epithelial-myoepithelial carcinoma (EMC) of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Breast epithelial myoepithelial carcinoma lacks therapeutic strategies due to its rarity, and currently local treatment is still the main treatment. Herein we report …

hk, cn (code pays fourni par la source)

Association between free water and longitudinal dynamics of recent small subcortical infarcts: a study based on diffusion tensor imaging

Tiantian Qiu, Hui Hong, Fuzhou Li, Lige Zhang et autres

The mechanisms underlying the different morphological evolution of recent small subcortical infarcts (RSSIs)-ranging from cavitation to complete disappearance-remain incompletely understood. Free water (FW), derived from diffusion tensor image, has emerged as a sensitive marker reflecting various pathophysiological processes that may influence RSSI …

cn (code pays fourni par la source)

Assessment of diffusivity along the perivascular space in early- and late-onset Alzheimer's disease

Xiao Luo, Hui Hong, Shuyue Wang, Kaicheng Li et autres

BackgroundCerebrospinal fluid (CSF) dynamics plays a key role in clearing soluble amyloid-β from the brain, which may impact Alzheimer's disease (AD) onset.ObjectiveThis study seeks to differentiate cerebrospinal fluid dysfunction between early-onset AD (EOAD) and late-onset AD (LOAD) subtypes and to examine their …

cn (code pays fourni par la source)

Deciphering the role of liver metabolic enzymes in dementia pathogenesis

Kaicheng Li, Jingyun Zhang, Hui Hong, Yeerfan Jiaerken et autres

The relationship between liver metabolic enzymes and the risk of dementia, as well as whether genetic factors can explain these potential associations, remains unclear. Based on data from 347,605 dementia-free British adults in the UK Biobank, we categorized participants into normal and …

cn (code pays fourni par la source)

Smoking alters effective connectivity of resting-state brain networks in mild cognitive impairment

Xiao Luo, Qingze Zeng, Kaicheng Li, Y. Chen et autres

Background Smoking, a modifiable risk factor for Alzheimer's disease (AD), is associated with impaired functional connectivity in resting-state networks (RSNs). This study investigates how smoking affects brain effective connectivity (EC). Objective Investigate smoking-associated EC alterations. Methods We identified 129 cognitively unimpaired (CU: …

cn (code pays fourni par la source)

Development of Neural Cells and Spontaneous Neural Activities in Engineered Brain‐Like Constructs for Transplantation (Adv. Healthcare Mater. 1/2025)

Ke Gai, Mengliu Yang, Wei Chen, Chenyujun Hu et autres

Transplanted Brain-Like Construct A material system with dynamic mechanical properties similar to brain tissue was proposed with human-derived neural progenitor cells (NPCs) as seed cells to build dot constructs with 3D bioprinting technology. Finally, in article 2401419, Yu Song, Feng Lin, and …

Predictive nomogram integrating radiomics and multi‐omics for improved prognosis‐model in cholangiocarcinoma

Mingyu Wan, Yifei Shen, Junli Wang, Xiao Luo et autres

cn (code pays fourni par la source)

Impact of sleep disruptions on gray matter structural covariance networks across the Alzheimer's disease continuum

Xiao Luo, Kaicheng Li, Qingze Zeng, Xiaocao Liu et autres

BACKGROUND: This study explores the impact of sleep disturbances on gray matter structural covariance networks (SCNs) across the Alzheimer's disease (AD) continuum. METHODS: Amyloid-negative participants served as controls, whereas amyloid positive (A+) individuals were categorized into six groups based on cognitive status …

cn (code pays fourni par la source)