Yeerfan Jiaerken

Dilated perivascular space is related to reduced free-water in surrounding white matter among healthy adults and elderlies but not in patients with severe cerebral small vessel disease

Ruiting Zhang, Xinfeng Yu, Dinggang Shen, Chunfeng Lian et autres

Perivascular space facilitates cerebral interstitial water clearance. However, it is unclear how dilated perivascular space (dPVS) affects the interstitial water of surrounding white matter. We aimed to determine the presence and extent of changes in normal-appearing white matter water components around dPVS …

us (code pays fourni par la source)

Imaging-Based Prediction Model for TOAST Classification in Acute Ischemic Stroke Using Cerebral Edema Progression Patterns

Honghui Xu, Feng Shi, Peiyu Huang, Ruiting Zhang et autres

cn (code pays fourni par la source)

MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk

Hui Hong, Yutong Chen, Dan Tozer, Yeerfan Jiaerken et autres

INTRODUCTION: Impaired cerebrospinal fluid (CSF) dynamics may contribute to dementia, but human evidence is limited. We examined associations between magnetic resonance imaging-based proxies of CSF dynamics and incident dementia, and whether CSF dysfunction mediates links between cardiovascular risk and dementia. METHODS: Using …

gb, cn (code pays fourni par la source)

LUMEN–A deep learning pipeline for analysis of the 3D morphology of the cerebral lenticulostriate arteries from time-of-flight 7T MRI

Rui Li, Soumick Chatterjee, Yeerfan Jiaerken, Xia Zhou et autres

The lenticulostriate arteries (LSAs) supply critical subcortical brain structures and are affected in cerebral small vessel disease (CSVD). Changes in their morphology are linked to cardiovascular risk factors and may indicate early pathology. 7T Time-of-Flight MR angiography (TOF-MRA) enables clear LSA visualisation. …

gb, de, cn (code pays fourni par la source)

Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum

Shuyue Wang, Fan Zhang, Qingze Zeng, Hui Hong et autres

Background and Objectivesβ-amyloid (Aβ) and tau, 2 prominent pathologies of Alzheimer disease (AD), originate in cortical regions and primarily affect, and even spread along, the white matter tracts directly connected to these cortical regions. Superficial white matter (SWM), containing short-range association connections …

cn, us (code pays fourni par la source)

Deciphering the role of liver metabolic enzymes in dementia pathogenesis

Kaicheng Li, Jingyun Zhang, Hui Hong, Yeerfan Jiaerken et autres

The relationship between liver metabolic enzymes and the risk of dementia, as well as whether genetic factors can explain these potential associations, remains unclear. Based on data from 347,605 dementia-free British adults in the UK Biobank, we categorized participants into normal and …

cn (code pays fourni par la source)

In Vivo Visualization of Charcot-Bouchard Aneurysms on Lenticulostriate Arteries Using 7T MRI

Yeerfan Jiaerken, Philip Benjamin, Christopher T. Rodgers, Lupei Cai et autres

BACKGROUND AND PURPOSE: Charcot-Bouchard aneurysms (CBAs) are tiny aneurysms arising from small perforating arteries. Despite the potentially catastrophic consequences of rupture of these aneurysms, the existence and prevalence of CBAs are controversial. The literature in this area is sparse with most previous …

gb, cn (code pays fourni par la source)

Longitudinal changes in white matter free water in cerebral small vessel disease: Relationship to cerebral blood flow and white matter fiber alterations

Lin Miao, Shuyue Wang, Hui Hong, Yao Zhang et autres

White matter (WM) free water (FW) is a potential imaging marker for cerebral small vessel disease (CSVD). This study aimed to characterize longitudinal changes in WM FW and investigate factors contributing to its elevation in CSVD. We included 80 CSVD patients and …

cn, nl (code pays fourni par la source)

Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression

Ruiting Zhang, Junghun Cho, Xinfeng Yu, Yeerfan Jiaerken et autres

Chronic hypoperfusion has been considered a major mechanism of cerebral small vessel disease. Nonetheless, brain tissue may increase oxygen extraction fraction to mitigate hypoxia and delay parenchymal damage. This study aims to investigate oxygen extraction fraction in cerebral small vessel disease and …

cn, us, nl (code pays fourni par la source)

A Deep Learning Pipeline for Analysis of the 3D Morphology of the Cerebral Small Perforating Arteries from Time-of-Flight 7 Tesla MRI

Rui Li, Soumick Chatterjee, Yeerfan Jiaerken, C. Radhakrishna et autres

Abstract The lenticulostriate arteries (LSA) supply important subcortical structures in the brain and are affected in cerebral small vessel disease (CSVD), leading to changes in their morphology. 7 Tesla Time-of-Flight magnetic resonance angiography (7T-TOF-MRA) now allows their visualisation in humans, but current …

gb, it, de, cn (code pays fourni par la source)

Development and validation of a perivascular space segmentation method in multi-center datasets

Peiyu Huang, Lingyun Liu, Yao Zhang, Siyan Zhong et autres

BACKGROUND: Perivascular spaces (PVS) visible on magnetic resonance imaging (MRI) are significant markers associated with various neurological diseases. Although quantitative analysis of PVS may enhance sensitivity and improve consistency across studies, the field lacks a universally validated method for analyzing images from …

cn (code pays fourni par la source)

A Mutual Multi-Scale Triplet Graph Convolutional Network for Classification of Brain Disorders Using Functional or Structural Connectivity

Pew‐Thian Yap, Dongren Yao, Yeerfan Jiaerken, Dinggang Shen et autres

Brain connectivity alterations associated with mental disorders have been widely reported in both functional MRI (fMRI) and diffusion MRI (dMRI). However, extracting useful information from the vast amount of information afforded by brain networks remains a great challenge. Capturing network topology, graph …

us (code pays fourni par la source)