Hao Li

Trimethylamine N‐oxide, a Gut Microbiota Metabolite, Promotes Diabetes‐Mediated Erectile Dysfunction via a PANoptotic‐Like Process Involving Pyroptosis, Apoptosis, and Necroptosis in CCSMCs

ZhanSen Huang, Ying Chen, Zi‐Jun Du, Hao Li et autres

BACKGROUND: Trimethylamine N-oxide (TMAO), a key metabolite derived from gut microbiota dysbiosis, is known to influence various diabetic vascular complications. However, its specific role and the programmed cell death mechanisms underlying the development of diabetes-mediated erectile dysfunction (DMED) remain to be fully …

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Prevalence and risk factors of headaches in middle-aged and older Chinese adults with hypertension: a cross-sectional study based on CHARLS

Weiyou Wang, Yao Wu, Xiaobing Xian, Haoran Shang et autres

Headache among individuals with hypertension warrants considerable clinical attention, yet evidence regarding its prevalence and associated factors in this population remains limited. Using data from the 2018 China Health and Retirement Longitudinal Study (CHARLS), this cross-sectional study included 2,186 middle-aged and older …

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Transfusion-related immunomodulation effect of erythrocyte characteristics on immune cells traits based on a multivariable Mendelian randomization study

Yujia Wang, Jinhuo Wang, H. Wang, Zhanyu Cheng et autres

BACKGROUND: Erythrocyte transfusion is the cornerstone of clinical practice, playing a vital role in treating various conditions such as severe blood loss, anemia, and certain hematological disorders. However, worries regarding the possible elevated hazard of transfusion-related immunomodulation (TRIM) persist. PURPOSE: We attempt …

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Electroacupuncture-Medication Combined Therapy Improves Sepsis Outcomes by Regulating PVN Neuronal Activities

Hongxia Ren, Jia‐Bao Liu, Huijuan Zhou, Hao Li et autres

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[The Effect of Platelet Irradiation on the Efficacy and Safety of Platelet Transfusion in Children with Hematological Disorders].

Xin Chen, Qin Liu, Hao Li, Jia Wang et autres

OBJECTIVE: To investigate the effect of platelet irradiation on the efficacy and safety of platelet transfusion in children with hematological disorders. METHODS: The platelet transfusion of 56 pediatric patients in the Hematology Department of Wuhan Children's Hospital from January to December 2023 …

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The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma

Laiwei You, Yang Zhou, Yong Cheng, Huan Wang et autres

BACKGROUND: The DPM1 gene, crucial for glycosylation processes, has shown abnormal expression in various cancers, raising interest in its potential oncogenic role and as a biomarker in hepatocellular carcinoma (HCC). METHODS: Transcriptomic data were obtained from The Cancer Genome Atlas (TCGA) and …

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Therapeutic Effect of Micro-Energy Treatment for Erectile Dysfunction: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

Hao Li, Wenchao Xu, Tao Wang, Jihong Liu et autres

PURPOSE: As an emerging therapeutic option for erectile dysfunction (ED), micro-energy treatment (MET) including low-intensity extracorporeal shockwave therapy, low-intensity pulsed ultrasound, and electromagnetic fields, has attracted increasing attention. We summarized the current literature to assess the therapeutic effect and find optimal treatment …

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Serum amyloid A1–induced intrahepatic regulatory T-cell dysfunction drives autoimmune hepatitis progression

Han Wang, Shuhui Wang, Lei Yu, Yu Chen et autres

BACKGROUND AND AIMS: Treatment of autoimmune hepatitis (AIH) remains challenging and primarily relies on corticosteroid therapy. Regulatory T cells (Tregs), essential for maintaining immune homeostasis and preventing various autoimmune diseases, present a potential therapeutic target for AIH. However, the role of Tregs …

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Identification of Safety Biomarkers for Autologous Blood Transfusion in Hepatocellular Carcinoma Patients

Yong Cheng, Yue Wang, Zhou Xiao-fang, Laiwei You et autres

Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer, constituting 75%-85% of all liver cancer cases. Despite advances in understanding HCC mechanisms and treatment options, challenges remain and further research is needed to uncover new therapeutic targets and improve patient …

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Does exercise training combined with blood flow restriction improve muscle mass, lower extremity function, and walking capacity in hemiplegic patients? A randomized clinical trial

Yali Feng, Yuan Yuan Chen, Wenwen Ye, Hang Jiang et autres

BACKGROUND: Blood flow restriction creates a state with increased motor function that permits treatment modalities to induce muscle hypertrophy. Blood flow-restricted exercise training (BFRET) may induce motor learning and boost the facilitatory effect of exercise training (ET). OBJECTIVE: This study investigated the …

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Metabolomics Analysis of Functional Activity Changes in Residual Tumour Cells After IOCS Treatment

Laiwei You, Jinhuo Wang, Dan Yin, Bo Hu et autres

Hepatocellular carcinoma (HCC) is a serious and often lethal cancer, particularly in patients with chronic liver disease. Currently, no specific treatment has been utilised to prevent HCC. The detailed mechanism of HCC is still elusive, and this study aims to identify and …

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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis

Yu Wen Cheng, Yang Jiao, Wan Wei, Yaodong Cai et autres

Background: Idiopathic Pulmonary Fibrosis (IPF), an interstitial lung disease of unknown etiology, remains incurable with current therapies, which fail to halt disease progression or restore lung function. However, Feibi Recipe No. 2 (FBR2), a clinically validated traditional Chinese medicine formula, exhibits potential …

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