[The Effect of Platelet Irradiation on the Efficacy and Safety of Platelet Transfusion in Children with Hematological Disorders].

Le résumé fourni par la source

OBJECTIVE: To investigate the effect of platelet irradiation on the efficacy and safety of platelet transfusion in children with hematological disorders. METHODS: The platelet transfusion of 56 pediatric patients in the Hematology Department of Wuhan Children's Hospital from January to December 2023 were retrospective analyzed. According to whether the platelets transfused by the patient have been irradiated, they are divided into irradiation group and non irradiation group. The effect of platelet irradiation on efficacy rate of transfusion and incidence of transfusion adverse reactions was analyzed. RESULTS: <0.05). In children with acute leukemia, there were statistical differences in 24 h CCI, the effective rate of transfusion, and adverse transfusion reactions between the irradiation and non-irradiation groups. CONCLUSION: Platelet irradiation can reduce the effective rate of platelet transfusion in children with hematological disorders, but can reduce the incidence of adverse transfusion reactions. To ensure the safety of blood use for pediatric patients, it is recommended to transfuse irradiated platelets to individuals who are susceptible to transfusion associated graft-versus-host disease (TA-GVHD), especially children with acute leukemia.

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