Wenchao Xu

中青年糖尿病患者眼调节参数变化的临床研究

Wenchao Xu, Ji Zhao, 郑佳明, 朱婉荧

目的探讨2型糖尿病（T2DM）对中青年患者眼调节功能参数的影响及其机制。方法选取吉林省人民医院内分泌科确诊为T2DM的30～45岁中青年患者及健康人作为研究对象。糖尿病（DM）组根据眼底病变分为无眼底病变糖尿病（NDR）组和非增殖型糖尿病性视网膜病变（NPDR）组，对照组为空腹血糖<6.1 mmol/L的健康人群。检测眼调节功能的各项参数：双眼调节幅度（AMP）、正相对调节（PRA）、负相对调节（NRA）、调节反应（AR）、调节性集合与调节比值（AC/A），比较三组的各项参数，同时分析不同分层血糖DM组患者眼调节参数间差异。采用Pearson相关性分析评价AMP与DM患者年龄（Age）、病程（DOD）、空腹血糖（FBG）及HbA1c的相关性，并进行多元回归分析。结果与对照组相比，DM组AMP、PRA显著下降（P<0.001），调节滞后量增加（P<0.001），且NPDR组AR高于NDR组（P<0.001）。随血糖升高，AMP、PRA逐渐下降（P<0.001），AR升高（P<0.001）。相关性分析显示，DM组患者AMP与Age、DOD、FBG、HbA1c均呈负相关（|r|=0.36~0.67，P<0.05）。多元回归分析结果，Age（P<0.001）、DOD（P=0.003）、FBG（P<0.001）是AMP的独立负向影响因素，而HbA1c（P=0.451）对AMP的影响无统计学意义。结论中青年T2DM患者在眼底发生改变前已出现眼AMP、PRA功能的下降及AR滞后（调节不足），且NPDR组患者AR滞后更加明显。DM组不同血糖分层患者的眼调节参数存在差异性，血糖数值越高，眼调节功能下降趋势越明显。Age、DOD、FBG是AMP的独立负向影响因素。

Iron overload disrupts bone homeostasis via TfR1-dependent ferroptosis and cGAS/STING-driven pyroptosis in pyogenic spondylitis

Wenchao Xu, Qinpeng Xu, Hongdong Tan, Xiaodong Liu et autres

Introduction Pyogenic spondylitis (PS) accompanies with diverse destruction, especially the subsequent bone destruction, which leads to spine instability and severe neurological disability. However, the mechanism underlying bone loss induced by infection has not been elucidated. In this study, we aimed to reveal …

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Metal-based nanomaterials for cancer phototherapy: current advancements and translational challenges

Hao Su, Xinyu Zhao, Wenchao Xu, Huanlan Sa et autres

Cancer remains a leading global health challenge, with limitations in chemotherapy, radiotherapy, and immunotherapy driving interest in alternative modalities. Phototherapy, comprising photodynamic therapy and photothermal therapy, has shown promising antitumor efficacy, yet conventional photosensitizers and photothermal agents often suffer from poor stability, …

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Research on the construction of a large-model agent for precision mental health services for college students

Wenchao Xu, Bingni Jia, Zihang Li

In response to the increasingly hidden nature of psychological distress among college students, the diversification of service needs, and the lag in service response, constructing a large-model agent to assist precision mental health services has considerable practical value. Relying on semantic understanding, …

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Correction: Sun et al. Engineered Adipose-Derived Stem Cells Overexpressing RXFP1 via CRISPR Activation Ameliorate Erectile Dysfunction in Diabetic Rats. Antioxidants 2023, 12, 171

Taotao Sun, Wenchao Xu, Bocheng Tu, Tao Wang et autres

In the original publication [...].

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Trend analyses of first-diagnosed reporting rate of chronic obstructive pulmonary disease among adult residents in Changzhou City from 2020 to 2024

MI Xiaomeng, NI Mingyang, XU Wenguo, Wenchao Xu

ObjectiveTo investigate the first-diagnosed reporting rate and annual changing trends of chronic obstructive pulmonary disease (COPD) among adult residents in Changzhou City from 2020 to 2024, and to provide a scientific basis for the prevention and control of COPD in this region.MethodsData …

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Characterization and therapy of fertilization failure in murine and human models with HNRNPR mutations

Shiming Gan, Yangyang Li, Lin Yin, Xiaotong Yang et autres

Oocyte activation is essential for successful fertilization and subsequent embryonic development. However, only a few disease-causing genes have been associated with sperm-derived oocyte activation failure, and the underlying molecular mechanisms and therapeutic approaches remain largely unknown. Here, we identified pathogenic mutations in …

Mozambique, cn, fr, th (code pays fourni par la source)

The beta1-adrenergic receptor in the heart

Wenchao Xu, Jie Li, Jie Ju, Min Liu et autres

Abstract beta1-adrenergic receptor (β 1 -AR) belongs to G protein-coupled receptors, regulating cardiac physiological and pathological process through complex signaling pathways. Physiologically, the activation of β 1 -AR produces positive chronotropic, positive inotropic and positive dromotropic effects in the heart. However, excessive …

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Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu et autres

Abstract Neurogenic bladder (NB)‐induced fibrosis is the major cause of irreversible bladder dysfunction, yet the underlying mechanisms remain undefined. Here, leveraging single‐cell RNA sequencing, the fibrotic landscape of NB is delineated and a distinct integrin α8 (Itga8) ⁺ fibroblast population. The Itga8⁺ …

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A phase I trial of combination CAR-NK92MI immunotherapy by dual targeting MUC-1 and PD-L1 for patients with relapsed or refractory solid tumors: focus on non-small cell lung cancer

Jing Lin, Wenchao Xu, Leiming Xia, Congshu Zhang et autres

BACKGROUND: NK92MI cells are well-defined natural killer (NK) cell lines for tumor immunotherapy. In this study, we investigated a combination therapy of MUC-1 and PD-L1 targeted chimeric antigen receptor NK92MI (CAR-NK92MI) cells for advanced non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: …

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N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction

Peng Hu, Sen Fu, Beining Li, Xiaoyu Zhu et autres

Homocysteine (Hcy) is an age-related risk factor for erectile dysfunction (ED), with enhanced vascular toxicity in middle-aged and elderly individuals. However, folate-based Hcy-lowering therapies have shown limited efficacy, necessitating a reevaluation of its age-dependent pathogenic mechanism. Here, we demonstrate that senescent endothelial …

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Therapeutic Effect of Micro-Energy Treatment for Erectile Dysfunction: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

Hao Li, Wenchao Xu, Tao Wang, Jihong Liu et autres

PURPOSE: As an emerging therapeutic option for erectile dysfunction (ED), micro-energy treatment (MET) including low-intensity extracorporeal shockwave therapy, low-intensity pulsed ultrasound, and electromagnetic fields, has attracted increasing attention. We summarized the current literature to assess the therapeutic effect and find optimal treatment …

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