Laiwei You

The correlation of DPM1 overexpression with immune infiltration and poor prognosis in hepatocellular carcinoma

Laiwei You, Yang Zhou, Yong Cheng, Huan Wang et autres

BACKGROUND: The DPM1 gene, crucial for glycosylation processes, has shown abnormal expression in various cancers, raising interest in its potential oncogenic role and as a biomarker in hepatocellular carcinoma (HCC). METHODS: Transcriptomic data were obtained from The Cancer Genome Atlas (TCGA) and …

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Identification of Safety Biomarkers for Autologous Blood Transfusion in Hepatocellular Carcinoma Patients

Yong Cheng, Yue Wang, Zhou Xiao-fang, Laiwei You et autres

Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer, constituting 75%-85% of all liver cancer cases. Despite advances in understanding HCC mechanisms and treatment options, challenges remain and further research is needed to uncover new therapeutic targets and improve patient …

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Metabolomics Analysis of Functional Activity Changes in Residual Tumour Cells After IOCS Treatment

Laiwei You, Jinhuo Wang, Dan Yin, Bo Hu et autres

Hepatocellular carcinoma (HCC) is a serious and often lethal cancer, particularly in patients with chronic liver disease. Currently, no specific treatment has been utilised to prevent HCC. The detailed mechanism of HCC is still elusive, and this study aims to identify and …

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Impact of Intraoperative Cell Salvage on Circulating Tumor Cells and Cellular Activity in Patients with Hepatocellular Carcinoma Undergoing Curative Resection: A Prospective Comparative Study

Ke Yue, Laiwei You, Baoji Hu, Yong Cheng et autres

Abstract This study investigates the effects of intraoperative cell salvage (IOCS) on cell survival rates, apoptosis levels, and circulating tumor cell (CTC) counts in patients with hepatocellular carcinoma (HCC) undergoing curative resection. A combination of immunofluorescence, Western blot, flow cytometry, and qRT-PCR …

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Exploration of the Clinical Effect of Different Autotransfusion Methods on Patients With Femoral Shaft Fracture Surgery

Yujia Wang, Huan Wang, Jiaming Xu, Jinhuo Wang et autres

OBJECTIVE: To explore the clinical effect of predeposit, salvage, and hemodilution autotransfusion on patients with femoral shaft fracture (FSF) surgery. METHODS: Selected patients with FSF were randomly divided into three groups: intraoperative blood salvage autotransfusion, preoperative hemodilution autohemotransfusion, and predeposit autotransfusion. Five …

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Anesthetic Management of a Patient With Hemoglobin M Disease Undergoing Laparoscopic Uterine Myomectomy: A Case Report

Laiwei You, Zhenzhou Li, Yong Cheng, Na Yao et autres

Hemoglobin M (Hb M) is a group of abnormal Hb variants that form methemoglobin, which leads to cyanosis. Patients with Hb M appear cyanotic but are usually asymptomatic. Cyanosis with low peripheral oxygen saturation is unresponsive to oxygen therapy despite normal partial …

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Effect of acute normovolemic hemodilution on anesthetic effect, plasma concentration, and recovery quality in elderly patients undergoing spinal surgery

Tong Liu, Yu Bai, Lei Yin, Jinhuo Wang et autres

Abstract Objective To explore the effect of acute normovolemic hemodilution (ANH) on the anesthetic effect, plasma concentration, and postoperative recovery quality in elderly patients undergoing spinal surgery. Methods A total of 60 cases of elderly patients aged 65 to 75 years who …

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Exploration of the mechanism of reinfusion of fresh autologous blood in type 2 diabetes mice to induce macrophage polarization and inhibit erythrocyte damage

She‐jun Hu, Jiaming Xu, Man‐di Wu, Ke Yue et autres

Abstract Aims/Introduction Type 2 diabetes triggers an inflammatory response that can damage red blood cells. M2 macrophages have inhibitory effects on inflammation, and play an important role in tissue damage repair and fibrosis. Autologous blood transfusion has the potential to inhibit red …

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WITHDRAWN: Exploration of the mechanism of reinfusion of fresh autologous blood in type 2 diabetic body to induce macrophage polarization and inhibit erythrocyte damage

She‐jun Hu, Jiaming Xu, Man‐di Wu, Ke Yue et autres

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Exploration of the effect of PUM1/Cripto-1 pathway on ferroptosis by regulating macrophage polarization in allogeneic blood transfused mice

Man-Di Wu, Yan Zhang, Huan Wang, Ke Yue et autres

Background: To study the link between macrophage polarization, PUM1/Cripto-1 pathway and ferroptosis in the allogeneic blood transfusion setting. Methods: This is an exploratory research. The purpose of this study was to investigate the effect of PUM1/Cripto-1 pathway on ferroptosis by regulating macrophage …

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Intraoperative blood auto-transfusion restrained the malignancy of Liver Cancer via regulating functions of tumor cells and Kuffer cells

Na Yao, Mandi Wu, Laiwei You, Jiaming Xu et autres

The role of IBA in regulating the recovery of liver cancer was investigated using a rat model of liver cancer and an intraoperative blood return model (IBA). SD rats were used to construct the IBA model. Kupffer cells were isolated from liver …

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Autologous blood transfusion impedes glycolysis in macrophages to inhibit red blood cell injury in type 2 diabetes through PI3K/Akt/PKM2 signaling axis

Yong Cheng, Huan Wang, Na Yao, Qin Ren et autres

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