Yan Ping

Genomic signals on the X chromosome reveal local adaptations in Ethiopian cattle

Wondossen Ayalew, Getinet Mekuriaw Tarekegn, Wu Xiaoyun, Min Chu et autres

BACKGROUND: In livestock, understanding the genetic basis of adaptation to the environment is essential for enhancing resilience to climate change and sustaining productivity in diverse environments. Indigenous Ethiopian cattle represent an ideal model for such studies, as they have evolved across a …

cn, gb, Éthiopie, kw, se, fi (code pays fourni par la source)

DNA encoded libraries

Alexander Lee Satz, Huan Liu, Yan Ping, Ren‐Qi Wang

us, cn (code pays fourni par la source)

PE (Prickly Eggplant) encoding a cytokinin-activating enzyme responsible for the formation of prickles in eggplant

Lei Zhang, Runzhi Zhang, Yan Ping, Liqian Zeng et autres

Abstract Eggplant is one of the most important vegetables worldwide, with some varieties displaying prickles. These prickles, present on the leaves, stems, and fruit calyxes, posing challenges during cultivation, harvesting, and transportation, making them an undesirable agronomic trait. However, the genetic mechanisms …

cn (code pays fourni par la source)

DELs enable the development of BRET probes for target engagement studies in cells

Kelly A. Teske, Wenji Su, Cesear R. Corona, Jing Wen et autres

DNA-encoded libraries (DELs) provide unmatched chemical diversity and starting points for novel drug modalities. Here, we describe a workflow that exploits the bifunctional attributes of DEL ligands as a platform to generate BRET probes for live cell target engagement studies. To establish …

us, cn (code pays fourni par la source)

DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor

Anthony P. Silvestri, Qi Zhang, Yan Ping, Erik W. Muir et autres

Synthetic macrocyclic peptides are an emerging molecular class for both targeting intracellular protein–protein interactions (PPIs) and providing an oral modality for drug targets typically addressed by biologics. Display technologies, such as mRNA and phage display, often yield peptides that are too large …

cn, us (code pays fourni par la source)

miR-449a ameliorates acute rejection after liver transplantation via targeting procollagen-lysine1,2-oxoglutarate5-dioxygenase 1 in macrophages

Zhenrui Cao, Wei-Xiong Zheng, Yu-Xin Jiang, Hao Chai et autres

Acute rejection (AR) is an important factor that leads to poor prognosis after liver transplantation (LT). Macrophage M1-polarization is an important mechanism in AR development. MicroRNAs play vital roles in disease regulation; however, their effects on macrophages and AR remain unclear. In …

cn (code pays fourni par la source)

Proteogenomics connects somatic mutations to signalling in breast cancer

Yan Ping, Francesca Petralia, Pei Wang, Kuan‐lin Huang et autres

Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood. We describe quantitative mass spectrometry-based proteomic and phosphoproteomic analyses of 105 genomically annotated breast cancers of which 77 provided …

us (code pays fourni par la source)

Characterization of CTX‐M‐type extended‐spectrum beta‐lactamase in clinical clones of Escherichia coli in Southwest China

Weidong Zhao, Yan Ping, Hai‐Ning Guan, Qun‐Zhi Zhang

The rapid and widespread dissemination of CTX-M-type extended-spectrum beta-lactamases (ESBLs) Escherichia coli in most of the provinces in China has been previously characterized; however, these enzymes have been rarely reported among minority regions. A prospective study using 180 E. coli clones from …

cn (code pays fourni par la source)

Optimization of Reflux Extraction Process for Total Flavonoids from Cupressus chengjana S.Y.Hu by Response Surface Methodology

Wang Wen-lan, Yang Mei, Yan Ping, Wang Xiao-ling

Objective:To optimize the reflux extraction of total flavonoids from leaves and stems of Cupressus chengjana S.Y.Hu.Methods:One-factor-at-a-time design and response surface methodology(RSM) were used to determine optimal conditions for the extraction of total flavonoids through regression analysis of the relationship between the extraction …

cn (code pays fourni par la source)

Effect of nutrition level on reproductive performance of Tan×Small Tail Han crossbred ewes

Yan Ping

The effects of(Ⅰ) 0.8×NRC,(Ⅱ) 0.9×NRC and(Ⅲ) 1.0×NRC levels of metabolic energy(ME) and crude protein(CP) on reproductive performance of ewes during the late period of pregnancy(97-150 d),lactation period(30 d) and flush period(from weaning of lambs to end of the second estrus cycle) were …

Preliminary Study of Utilizing Intensity Modulated Radiotion Therapy (IMRT) Inverse Algorithm to Actualize Three-dimensional Conformal Radiotherapy

Yan Ping

Objective To actualize three-dimensional conformal radiotherapy by using intensity modulated radiotherapy therapy (IMRT) inverse algorithm.Methods 5 cases of non-small cell lung cancer patients are given a three-dimensional conformal and one surbeam intensity modulated radiation therapy in order to compare conformal angle,MU and …

Evaluation of the DNA Content in Leukocytes by Flow Cytometry for Determination of the Postmortem Interval

Rong Bao, Yan Ping, Xue-ju Qu, Sun Zhen et autres

Objective: To evaluate the proportion of cell debris and fluorescence intensity of diploidy to determine the postmortem interval(PMI).Methods: Specimens of 2 ml blood were drawn from 13 men(18 years old) and were anticoagulated with heparin;the other specimens of 1 ml blood was …