Wenji Su

Direct-to-Biology Strategy Accelerates CRBN-Targeting Molecular Glue Degrader Discovery

Hao Chen, Zuyuan Shen, Qi Qu, Jiliang Chen et autres

Abstract Molecular glue degraders (MGD), a new drug modality that utilizes the natural proteasomal degradation machinery in cells for target protein degradation, is drawing great attraction from the pharmaceutical industry in recent years. However, the pace of MGD molecule discovery can be …

cn, us (code pays fourni par la source)

Cyclic compression–shear behavior and degradation of multi-key block mold-formed bonding interfaces in precast shear wall horizontal joints

Fei Yu, Qing Jiang, Xun Chong, Lingkai Zhang et autres

cn (code pays fourni par la source)

RNA theranostics

Hui Zhou, Wenji Su, Liyi Fu, Dean Shuailin Chen et autres

us, cn (code pays fourni par la source)

The Influence of Single-Stranded or Double-Stranded DNA Tags on Ligand Binding Affinity in DNA-Encoded Libraries

Philipp Bittner, Andreas Gloger, Julian Alexander Harrison, Adam Pruška et autres

DNA-encoded libraries have become widely used in drug discovery, and several different setups to link chemical compounds to DNA have been employed in the field, including single-stranded and double-stranded DNA tags as well as a variety of linker chemistries. In our previous …

ch (code pays fourni par la source)

Van Leusen Imidazole Synthesis for One-Bead-One-Compound DNA-Encoded Libraries

Yihui Xie, Min-Chi Huang, Yanfen Jiang, Xiaoming Miao et autres

One-bead-one-compound (OBOC) DNA-encoded library (DEL) enables high-throughput activity-based screening to find novel hits against pharmaceutical targets. Herein, we developed solid-phase and DNA-compatible conditions to implement the three-component Van Leusen reaction (imidazole formation) for OBOC DELs. High-throughput validation was conducted (employing every potential …

cn, de, us (code pays fourni par la source)

Native Mass Spectrometry Facilitates Hit Validation in DNA‐Encoded Library Technology

Philipp Bittner, Andreas Gloger, Michelle Keller, Sebastian Oehler et autres

DNA-encoded Library (DEL) Technology has become a workhorse of drug development, is widely employed in an industrial and academic setting, and an increasing number of drugs developed by DEL technology have entered clinical stage development. While up to billions of compounds can …

ch (code pays fourni par la source)

Native Massenspektrometrie erleichtert die Hit‐Validierung in der DNA‐Encoded Library Technologie

Philipp Bittner, Andreas Gloger, Michelle Keller, Sebastian Oehler et autres

Zusammenfassung Die DNA‐encoded Library (DEL) Technologie hat sich als zentrales Instrument der Wirkstoffentwicklung etabliert und wird sowohl in der Industrie als auch in der akademischen Forschung breit eingesetzt. Eine zunehmende Anzahl von durch DEL entwickelten Wirkstoffen befindet sich in der klinischen Entwicklung. …

ch, iq (code pays fourni par la source)

DNA-Compatible Huisgen [3 + 2] Cycloaddition of In Situ Formed Nitrile Oxides with Alkenes or Alkynes to Synthesize Isoxazolines or Isoxazoles

Gaonan Wang, Xiaona Zhang, Hui Zhu, Xiaodong Shi et autres

DNA-encoded chemical library (DECL) technology is recognized as a robust screening platform for drug discovery. Developing new DNA-compatible reactions is crucial for expanding the chemical space of DECLs. Cyclization reactions, particularly those involving the formation of heterocycles, offer unique and efficient methods …

cn (code pays fourni par la source)

Development of a DNA-encoded library screening method “DEL Zipper” to empower the study of RNA-targeted chemical matter

Zhongyao Ma, Bin Zou, Jiannan Zhao, Rui Zhang et autres

To date, RNA-targeted chemical matter is under explored due to a lack of robust screening assays. In this study, we present a novel RNA-targeted small molecule screening approach using a specialized DNA-encoded library (DEL). Our findings reveal that the specialized DEL library, …

cn, us (code pays fourni par la source)

Effectiveness evaluation of cooling measures for express highway construction in permafrost regions based on GPR and ERT

Yunhui Huang, Fujun Niu, Peifeng He, Weidong Pan et autres

cn (code pays fourni par la source)

Development of a DNA-encoded library screening method DEL Zipper to empower the study of RNA-targeted chemical matter

Zhongyao Ma, Bin Zou, Jiannan Zhao, Rui Zhang et autres

To date, RNA-targeted chemical matter is under explored due to a lack of robust screening assays. In this study, we present a novel RNA-targeted small molecule screening approach using a specialized DNA-encoded library (DEL). Our findings reveal that the specialized DEL library, …

cn, us (code pays fourni par la source)

Highly Selective Novel Heme Oxygenase-1 Hits Found by DNA-Encoded Library Machine Learning beyond the DEL Chemical Space

Shuai Han, Xinyun Guo, Min Wang, Huan Liu et autres

High Resolution Image Download MS PowerPoint Slide DNA-encoded library (DEL) technology, especially when combined with machine learning (ML), is a powerful method to discover novel inhibitors. DEL-ML can expand a larger chemical space and boost cost-effectiveness during hit finding. Heme oxygenase-1 (HO-1), …

cn, us (code pays fourni par la source)