Accès ouvert
2026
preprint
OpenAlex
Akhil Pallerla, Chloe C. Lucido, Kai Saito, Georgia L. Nolt et autres
Anti-amyloid antibodies represent the first disease modifying therapeutics for Alzheimers disease (AD). Adoption of these novel treatments has been slowed by the occurrence of amyloid related imaging abnormalities (ARIA) - treatment-associated edema (ARIA-E) or microhemorrhages (ARIA-H) that disproportionately affect carriers of the …
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Accès ouvert
2026
article
OpenAlex
Georgia L. Nolt, Chloe C. Lucido, Lily M. Smith, Lance A. Johnson
Apolipoprotein E ( APOE ) is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and encodes a major lipid transporter in the central nervous system (CNS). Although apoE has been studied extensively, fundamental questions remain regarding its expression across the …
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Accès ouvert
2026
article
OpenAlex
X. -M. Wang, Mikkel Baldtzer Liisberg, Vanessa Rück, Sagar Pande et autres
ABSTRACT Nanocarriers play a critical role in the transport and targeted delivery of therapeutic agents. However, real‐time in vivo observation of individual nanocarriers in the circulatory system is challenging due to the need for high spatiotemporal resolution and sensitivity. Here, DNA‐stabilized silver …
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Accès ouvert
2025
article
OpenAlex
Kumar Pandya, Scott M. Gordon, Brandon C. Farmer, Shannon L. Macauley et autres
Compared to individuals carrying two copies of the ε4 allele of apolipoprotein E (APOE), ε2 homozygotes have an approximate 99% reduction in late-onset Alzheimer's disease (AD) risk. Here we develop a knock-in model that allows for an inducible 'switch' between risk and …
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Accès ouvert
2025
article
OpenAlex
Georgia L. Nolt, Lesley R. Golden, Jessica L. Funnell, Isaiah O. Stephens et autres
Demyelination occurs with aging and is exacerbated in neurodegenerative diseases. During demyelination, microglia upregulate expression of APOE, the gene encoding for the brain's primary lipid transport protein apolipoprotein E (ApoE), which also mediates microglial engulfment and elimination of myelin debris. Compared to …
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Accès ouvert
2025
article
OpenAlex
Lesley R. Golden, Dahlia Siano, Isaiah O. Stephens, Steven M. MacLean et autres
Compared to individuals carrying two copies of the ε4 allele of apolipoprotein E (APOE), ε2 homozygotes have an approximate 99% reduction in late-onset Alzheimer’s disease (AD) risk. Here we develop a knock-in model that allows for an inducible ‘switch’ between risk and …
us
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Accès ouvert
2025
preprint
OpenAlex
Kai Saito, Danielle S. Goulding, Georgia L. Nolt, Sophia H. Dimas et autres
Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-driving) microglial heterogeneity. However, our understanding of how proximity to these Alzheimer's disease (AD) pathological hallmarks in situ relates …
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Accès ouvert
2024
article
OpenAlex
Georgia L. Nolt, Steven M. MacLean, Lesley R. Golden, Isaiah O. Stephens et autres
BACKGROUND: Compared with the E3 allele of Apolipoprotein E (APOE), E4 increases late-onset Alzheimer's Disease (AD) risk up to 15-fold, while the E2 allele substantially decreases risk. In the CNS, ApoE is predominantly synthesized by astrocytes and microglia, making these two cell …
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Accès ouvert
2023
article
OpenAlex
Benjamin I. Burke, Jensen Z. Goh, Fatmah A. Albathi, Taylor R. Valentino et autres
Introduction: Apolipoprotein E (ApoE) has been shown to be necessary for proper skeletal muscle regeneration. Consistent with this finding, single-cell RNA-sequencing analyses of skeletal muscle stem cells (MuSCs) revealed that Apoe is a top marker of quiescent MuSCs that is downregulated upon …
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Accès ouvert
2023
article
OpenAlex
Georgia L. Nolt, Alexander R. Keeble, Yuan Wen, Aubrey C. Strong et autres
Abstract Skeletal muscle adaptation to external stimuli, such as regeneration following injury and hypertrophy in response to resistance exercise, are blunted with advanced age. The accumulation of senescent cells, along with defects in myogenic progenitor cell (MPC) proliferation, have been strongly linked …
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Accès ouvert
2023
article
OpenAlex
Xiaojin Wang, Mikkel Baldtzer Liisberg, Georgia L. Nolt, Xu Fu et autres
Unraveling the transport of drugs and nanocarriers in cerebrovascular networks is important for pharmacokinetic and hemodynamic studies but is challenging due to the complexity of sensing individual particles within the circulatory system of a live animal. Here, we demonstrate that a DNA-stabilized …
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Accès ouvert
2022
article
OpenAlex
Cory M. Dungan, Camille R. Brightwell, Yuan Wen, Christopher J. Zdunek et autres
Abstract Murine exercise models can provide information on factors that influence muscle adaptability with aging, but few translatable solutions exist. Progressive weighted wheel running (PoWeR) is a simple, voluntary, low-cost, high-volume endurance/resistance exercise approach for training young mice. In the current investigation, …
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