Akhil Pallerla

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

Akhil Pallerla, Chloe C. Lucido, Kai Saito, Georgia L. Nolt et autres

Anti-amyloid antibodies represent the first disease modifying therapeutics for Alzheimers disease (AD). Adoption of these novel treatments has been slowed by the occurrence of amyloid related imaging abnormalities (ARIA) - treatment-associated edema (ARIA-E) or microhemorrhages (ARIA-H) that disproportionately affect carriers of the …

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Abstract Wed026: HDL-Associated Proteins Bind HDL via Protein-Protein Interactions with ApoA1 and ApoA2

Ryan Barney, Alexander Karakashian, Akhil Pallerla, Abby Burrows-Franco et autres

Introduction: HDL is a compositionally complex lipoprotein, carrying a wide variety of proteins that may mediate its observed functional heterogeneity. Studies over the last 2 decades have identified over 250 proteins as being associated with HDL. However, many of these studies have …

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319 Clonal expansion of cytotoxic CD8 + T-cells in lecanemab-associated ARIA

Akhil Pallerla, Lance A. Johnson, Kai Saito, Jessica L. Funnell et autres

Objectives/Goals: The goal of this study was to determine if there are the peripheral immune system changes in persons undergoing treatment with lecanemab, and whether those changes are associated with the incidence of amyloid-related imaging abnormalities (ARIA), in order to identify strategies …

Moderate Aortic Stenosis in Patients With Heart Failure

Vien T. Truong, John Ernst, Akhil Pallerla, Amitesh Verma et autres

BACKGROUND AND OBJECTIVES: Moderate aortic stenosis (AS) confers a surprisingly adverse prognosis, approaching that of severe AS. The objective of this study was to describe the clinical course of patients with moderate AS with evidence of concomitant heart failure manifesting as elevated …

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Dynamic nomogram for predicting pacemaker implantation following transcatheter aortic valve replacement

Vien T. Truong, Daniel Beyerbach, Wojciech Mazur, Matthew Wigle et autres

Data are available for the researchers who meet the criteria for access to confidential data. Requests for data access can be sent to the corresponding author at eugene.chung@thechristhospital.com .

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Machine learning method for predicting pacemaker implantation following transcatheter aortic valve replacement

Vien T. Truong, Daniel Beyerbach, Wojciech Mazur, Matthew Wigle et autres

BACKGROUND: An accurate assessment of permanent pacemaker implantation (PPI) risk following transcatheter aortic valve replacement (TAVR) is important for clinical decision making. The aims of this study were to investigate the significance and utility of pre- and post-TAVR ECG data and compare …

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PACEMAKER IMPLANTATION FOLLOWING TAVR: USING MACHINE LEARNING TO OPTIMIZE RISK STRATIFICATION

Vien T. Truong, Matthew Wigle, Emma A. Bateman, Akhil Pallerla et autres

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