Cory M. Dungan

Cellular senescence in skeletal muscle: myogenic and nonmyogenic cell populations, mechanisms, and therapeutic opportunities

Κωνσταντίνος Παπανικολάου, Angad Yadav, Robert T. Mankowski, M. Yvonne Alexander et autres

Skeletal muscle plays a central role in systemic metabolism, physical function, and overall health. Aging and disease diminish the ability of myogenic and nonmyogenic skeletal muscle cells to coordinate adaptation and repair, but the mechanisms underlying this decline are not fully understood. …

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Surviving the Cure: Modeling the Long-Term Consequences of Chemotherapy

Rachel Chiella, Jaden Wells, Sajedeh B Tabrizi, Savannah V Rauschendorfer et autres

Due to advances in treatment protocols, survival rates for childhood cancers have improved significantly over the past several decades, with five-year survival now reaching 85%. However, survivorship often comes at a cost, as exposure to intensive chemotherapy impairs skeletal muscle health, reducing …

Myonuclear loss, rather than senescent myonuclei, associates with fiber type-specific atrophy in aging human skeletal muscle

Carlos S. Zepeda, Isabell Dobrzycki, Paige Acklie, Cory M. Dungan et autres

Age-related reductions in whole-muscle function are attributed, in part, to pronounced atrophy of muscle fibers expressing the fast myosin heavy chain (MyHC) II isoforms. Senescence, a state of irreversible cell cycle arrest that can be characterized by DNA damage (γH2AX) and chromatin …

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Pediatric CHOP chemotherapy acutely disrupts satellite-cell dynamics and blunts muscle mass in a sex-specific manner

Jainil Daredia, Marc A Magaña, Carla Manuela Crispim Nascimento, Jaden M. Wells et autres

Multiagent CHOP chemotherapy in juvenile mice impairs muscle growth and alters transcriptional programs in a sex-specific manner. CHOP-treated mice showed lower satellite cell abundance and smaller muscle fibers, with RNA-seq revealing distinct gene expression profiles enriched for myogenic regulators, extracellular matrix, and …

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Stem Cell Aging and Senescence in Skeletal Muscle

Cory M. Dungan, Camille R. Brightwell, Christopher Fry

Treatment With Combination Chemotherapy (chop) Causes Deleterious Effects On Muscle Mass In Juvenile Mice

M A Pulido Magaña, Carla MC Nascimento, Jaden M. Wells, Jainil Daredia et autres

Pediatric non-Hodgkin lymphoma (NHL) is a common childhood cancer. While combination chemotherapy (chemo) regimens like CHOP (cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone) have significantly improved survival rates, they often induce adverse side effects. Although muscle atrophy is a well-recognized consequence of cancer therapy, the …

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Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice

Kevin A. Murach, Cory M. Dungan, Toby L. Chambers, Steve Horvath et autres

Adult resident stem cells are capable of regenerating tissues that manifest signs of "rejuvenation" in flatworms and mice of older ages. These findings suggest potentially conserved regulatory mechanisms of adult resident stem cells from worms to mammals. Regenerative capacities are more limited …

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Pediatric CHOP Chemotherapy Acutely Disrupts Satellite-Cell Dynamics and Blunts Muscle Mass in a Sex-Specific Manner

Jainil Daredia, Marc A Magaña, Carla MC Nascimento, Jaden M. Wells et autres

Abstract Pediatric cancer survival now exceeds 85 percent owing, in part, advances and use of combination chemotherapy treatments such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). Despite its efficacy, CHOP may cause deleterious off-target effects during critical pediatric development periods such as …

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At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( BI01 ) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Toby L. Chambers, Jaden M. Wells, Pieter J. Koopmans, Francielly Morena da Silva et autres

ABSTRACT Senescent cells emerge with aging and injury. The contribution of senescent cells to DNA methylation age (DNAmAGE) in vivo is uncertain. Furthermore, stem cell therapy can mediate “rejuvenation”, but how tissue regeneration controlled by resident stem cells affects whole tissue DNAmAGE …

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A satellite cell‐dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity

Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan et autres

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical …

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Gastrocnemius Mass Is Lower 28 Days After Recovery From A Cycle Of Cisplatin In Mice

Marc A Magaña, Jaden M. Wells, Carla Manuela Crispim Nascimento, Cory M. Dungan et autres

BACKGROUND: Platinum-based chemotherapeutic agents, such as cisplatin, are widely employed as a primary treatment modality for various cancer types. Despite their efficacy, cisplatin's mechanism of action involves inducing DNA damage in cells, leading to pronounced acute and long-term side effects. One well …

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Marker Of Mitochondrial Quality Control In Mice Gastrocnemius Muscle Following Recovery From Cisplatin Chemotherapy Treatment.

Carla MC Nascimento, M A Pulido Magaña, Jaden M. Wells, Cory M. Dungan et autres

BACKGROUND: Cisplatin is a common chemotherapy drug however, its use is associated with notably muscle wasting. Evidence suggests cisplatin-induced atrophy is caused by mitochondrial dysfunction stemming from changes to biogenesis, mitophagy, and fusion and fission, termed mitochondrial quality control. There is a …

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