Alexandre Desroches

Apelin stimulation of the vascular skeletal muscle stem cell niche enhances endogenous repair in dystrophic mice

Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier et autres

Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here, we showed that defects in the endothelial cell (EC) compartment of the vascular stem cell niche in mouse models of Duchenne …

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Apelin Stimulation of the Perivascular MuSC Niche Enhances Endogenous Repair in Muscular Dystrophy

Emméran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier et autres

Abstract Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here we describe that defects in the endothelial cell (EC) compartment of the perivascular stem cell niche in three different types …

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RNA as a binding intermediate for an efficacious cleavage of substrates by caspase-7

Alexandre Desroches

L’apoptose est une forme de mort cellulaire programmée qui permet l’élimination des cellules infectées, dysfonctionnelles ou endommagées. Le déclanchement de l’apoptose se fait suite à l’intégration de signaux provenant de l’intérieur ou de l’extérieur de la cellule et résulte en l’activation de …

Characterization of caspase-7 interaction with RNA

Alexandre Desroches, Jean‐Bernard Denault

Apoptosis is a regulated form of cell death essential to the removal of unwanted cells. At its core, a family of cysteine peptidases named caspases cleave key proteins allowing cell death to occur. To do so, each caspase catalytic pocket recognizes preferred …

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RNA-seq Data.xlsx

Alexandre Desroches, Jean‐Bernard Denault

RNA-seq data for caspase-7 bound and input RNAs

Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins

Alexandre Desroches, Jean‐Bernard Denault

KKK) located in the N-terminal domain of caspase-7 form such an exosite and promote the rapid proteolysis of the poly(ADP-ribose) polymerase 1 (PARP-1), but the mechanism of recognition remains mostly unknown. In this study, we show that the overall positive charge of …

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Caspase Family

Alexandre Desroches, Dave Boucher, Jean‐Bernard Denault

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Caspase Family

Alexandre Desroches, Dave Boucher, Jean‐Bernard Denault

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