Simona Bussolati

Ivermectin effects in cultured endothelial cells from porcine corpus luteum

Giuseppina Basini, M Berni, Laura Mazzera, Martina Tambassi et autres

Ivermectin (IVM), a widely used antiparasitic, raises emerging concerns regarding reproductive toxicity. This study investigated the effects of clinically relevant IVM concentrations (20, 40, 60 ng/mL) on endothelial cells from porcine corpus luteum, a translational model for vascular function. Proliferation and metabolic …

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Cross-species oncolytic virotherapy in vitro: BoHV4EGFPΔTK as a novel candidate against canine osteosarcoma and histiocytic sarcoma

M. Di Pentima, Sergio Minesso, Valentina Franceschi, Rosanna Di Lecce et autres

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Evaluation of the ivermectin effects on porcine granulosa cell function

Giuseppina Basini, Fausto Quintavalla, Simona Bussolati, Francesca Grasselli

Ivermectin (IVM) is used as antiparasitic drug in veterinary medicine and it is also the only avermectin approved in humans in several parasitic infestations. We examined this substance because potential critical issues associated with the use were highlighted. Moreover, criticisms related to …

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Toxic effects of nanoplastics on a model of dog aortic cells

Giuseppina Basini, Martina Tambassi, Simona Bussolati, Francesca Grasselli et autres

Nanoplastic fragments (NP) are a growing concern and using dog aortic endothelial cells (CnAEOC) and fluorescence microscopy, we observed an interaction between NP and cells, demonstrating a localization at the cytoplasmic level. Furthermore, the data collected show a disruption of both cell …

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Monitoring of oxidative stress biomarkers in different production stages and periods of the year in goats in semi-intensive farming

Giuseppina Basini, Fausto Quintavalla, Simona Bussolati, Michelle Sartori et autres

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Fine Particulate Matter (PM) Effects on Swine Granulosa and Ovarian Endothelial Cells

Giuseppina Basini, Roberto Ramoni, Stefano Grolli, Simona Bussolati et autres

We studied fine particulate matter (PM) effects on porcine granulosa, a model of endocrine reproductive cells, and on ovarian endothelial cells. PM produced a significant decrease (p < 0.05) in metabolic activity. PM reduced endothelial cell proliferation (p < 0.001). As for …

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Detection of microplastics in the feline placenta and fetus

Ilaria Ferraboschi, Francesca Canzolino, Elena Ferrari, Cristina Sissa et autres

The present study aimed to detect microplastics in feline placentas and fetuses in the early stage of pregnancy. For this study, 8 pregnant queens were evaluated. A standardized protocol for the digestion of biological matter was used, as well as a plastic-free …

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The porcine corpus luteum as a model for studying the effects of nanoplastics

Giuseppina Basini, Simone Bertini, Simona Bussolati, Francesca Zappavigna et autres

Nanoplastics (NPs) affect fertility. We evaluated the effects of NPs treatment on luteal and endothelial cells. We examined crucial markers of growth and redox status. NPs treatment did not induce changes in ATP levels in luteal cells, while it increased (p< 0.05) …

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Blood plasma and urinary biomarkers of oxidative stress in cats with urethral obstruction

Fausto Quintavalla, Giuseppina Basini, Francesca Fidanzio, Simona Bussolati et autres

Abstract Background This study aimed to investigate variations of the oxidative status in cats affected by urethral obstruction (UO) under Feline Idiopathic Cystitis (FIC) and Bacterial Cystitis (BC), in comparison with a group of healthy subjects. In both groups, the levels of …

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Are the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures

Giuseppina Basini, Simona Bussolati, Stefano Grolli, Priscilla Berni et autres

Phthalates are plasticizing chemicals, widely used in packaging materials and consumer products for several decades. These molecules have raised concerns because of their toxicity and their use have been restricted in several countries. Therefore, novel phthalates have been introduced. Among these, diisononilphtalate …

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Nanoplastics induced oxidative stress and VEGF production in aortic endothelial cells

Giuseppina Basini, Stefano Grolli, Simone Bertini, Simona Bussolati et autres

Plastic is an important environmental issue and a more critical aspect concerns plastic fragments, mainly in term of nanoplastics (NPs). We demonstrated that NPs interfere with reproductive and adipose stromal cells. Since several research underlined an increased cardiovascular risk due to NPs, …

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Perfluorooctanoic acid (PFOA) affects steroidogenesis and antioxidant defence in granulosa cells from swine ovary

Giuseppina Basini, Simona Bussolati, Veronica Torcianti, Francesca Grasselli

PFOA is mainly employed in products with water and oil repellent properties. Due to its persistence, bioaccumulation and critical effects on health, its use has been restricted in several countries. This research was intended to explore PFOA action on the main functions …

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