Laura Mazzera

Lpb. plantarum inhalation powders for the reduction of lung inflammation and S. aureus growth control in non-CF bronchiectasis

Stefania Glieca, Martina Tambassi, Chiara Schianchi, Eride Quarta et autres

The reduced diversity of the lung microbiome in respiratory conditions, including bronchiectasis, promotes bacterial infection and inflammation, contributing to worsening clinical outcomes. Traditional treatments often fail to address both infection and inflammation. Because of their potential dual-action, lactic acid bacteria (LAB) directly …

Lpb. plantarum inhalation powders for the reduction of lung inflammation and S. aureus growth control in non-CF bronchiectasis

Stefania Glieca, Martina Tambassi, Chiara Schianchi, Eride Quarta et autres

The reduced diversity of the lung microbiome in respiratory conditions, including bronchiectasis, promotes bacterial infection and inflammation, contributing to worsening clinical outcomes. Traditional treatments often fail to address both infection and inflammation. Because of their potential dual-action, lactic acid bacteria (LAB) directly …

Lpb. plantarum inhalation powders for the reduction of lung inflammation and S. aureus growth control in non-CF bronchiectasis

Stefania Glieca, Martina Tambassi, Chiara Schianchi, Eride Quarta et autres

INTRODUCTION The reduced diversity of the lung microbiome in respiratory conditions, including bronchiectasis, promotes bacterial infection and inflammation, contributing to worsening clinical outcomes. Traditional treatments often fail to address both infection and inflammation. Because of their potential dual-action, lactic acid bacteria (LAB) …

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Lpb. plantarum inhalation powders for the reduction of lung inflammation and S. aureus growth control in non-CF bronchiectasis

Stefania Glieca, Martina Tambassi, Chiara Schianchi, Eride Quarta et autres

The reduced diversity of the lung microbiome in respiratory conditions, including bronchiectasis, promotes bacterial infection and inflammation, contributing to worsening clinical outcomes. Traditional treatments often fail to address both infection and inflammation. Because of their potential dual-action, lactic acid bacteria (LAB) directly …

Retraction Note: MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia

Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni et autres

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Ivermectin effects in cultured endothelial cells from porcine corpus luteum

Giuseppina Basini, M Berni, Laura Mazzera, Martina Tambassi et autres

Ivermectin (IVM), a widely used antiparasitic, raises emerging concerns regarding reproductive toxicity. This study investigated the effects of clinically relevant IVM concentrations (20, 40, 60 ng/mL) on endothelial cells from porcine corpus luteum, a translational model for vascular function. Proliferation and metabolic …

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The Results After One Year of an Experimental Protocol Aimed at Reducing Paratuberculosis in an Intensive Dairy Herd

Anita Filippi, Giordano Ventura, Antonella Lamontanara, Luigi Orrù et autres

(MAP). The disease is characterized by a chronic and incurable enteritis in ruminants and it is responsible for significant economic losses, also raising concerns about food safety and animal welfare. Effective control is hindered by diagnostic limitations, long incubation periods, and the …

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M. caprae in northern Italy: a comprehensive analysis through whole-genome sequencing on the genetic variability in bovine herds

Cristina Bertasio, Valentina Carta, Giovanni Parisio, Mariagrazia Zanoni et autres

Mycobacterium (M.) bovis and M. caprae are the causative agents of bovine tuberculosis (bTB), which is still a concern due to its health implications and economic impact. Although M. caprae is less prevalent than M. bovis among bovine tuberculosis cases, it has …

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Emergence of Salmonella enterica carrying blaOXA-181 carbapenemase gene, Italy, 2021 to 2024

Luca Bolzoni, Erika Scaltriti, Chiara Bracchi, Sara Angelone et autres

Between 2021 and 2024, we detected carbapenemase gene blaOXA-181 in 16 of 11,398 Salmonella enterica (SE) isolates: 10 SE 1,4,[5],12:i:-, three Bovismorbificans, two London and one Rissen from pigs, humans, pork meat and wild roe deer. The gene was first detected in …

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Salmonella pathogenicity Island 1 undergoes decay in serovars adapted to swine and poultry

Martina Tambassi, M Berni, Chiara Bracchi, Ilaria Menozzi et autres

ABSTRACT Human salmonellosis is a high-priority foodborne disease worldwide. The main reservoir of Salmonella is livestock, mainly swine and poultry that are infected both by generalist serovars and serovars adapted to them. The most widespread livestock-adapted serovars are attenuated in both their …

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RETRACTED ARTICLE: MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia

Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni et autres

Abstract Resistance to tyrosine kinase inhibitors (TKIs) remains a clinical challenge in Ph-positive variants of chronic myeloid leukemia. We provide mechanistic insights into a previously undisclosed MEK1/2/BCR::ABL1/BCR/ABL1-driven signaling loop that may determine the efficacy of arsenic trioxide (ATO) in TKI-resistant leukemic patients. …

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Functional interplay between NF-κB-inducing kinase and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma

Laura Mazzera, Manuela Abeltino, Guerino Lombardi, Anna Maria Cantoni et autres

Considering that Aurora kinase inhibitors are currently under clinical investigation in hematologic cancers, the identification of molecular events that limit the response to such agents is essential for enhancing clinical outcomes. Here, we discover a NF-κB-inducing kinase (NIK)-c-Abl-STAT3 signaling-centered feedback loop that …

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